05049nam 2200565 450 991082739270332120230807214011.01-118-73277-41-118-73274-X(CKB)3710000000373642(EBL)1895565(Au-PeEL)EBL1895565(CaPaEBR)ebr11032998(CaONFJC)MIL769845(OCoLC)897946695(MiAaPQ)EBC1895565(EXLCZ)99371000000037364220150326h20152015 uy 0engur|n|---|||||rdacontentrdamediardacarrierNeuroinflammation new insights into beneficial and detrimental functions /edited by Samuel DavidHoboken, New Jersey :John Wiley & Sons,2015.©20151 online resource (322 p.)Description based upon print version of record.1-118-73282-0 Includes bibliographical references and index.Cover; Title Page; Copyright; Contents; Contributors; Preface; Part I Introduction; Chapter 1 Immune Response in the Human Central Nervous System in Multiple Sclerosis and Stroke; Introduction; The Concept of Neuroinflammation; Basic Principles of Immune Surveillance and Inflammation by Adaptive Immune Responses; Inflammation in the Central Nervous System of Patients with Multiple Sclerosis; Inflammation in Stroke Lesions; Microglia Activation and Macrophage Response; Granulocyte Infiltration; Conclusions; ReferencesChapter 2 In Vivo Imaging of Glial and Immune Cell Responses in Central Nervous System Injury and DiseaseIntroduction; Intravital Microscopy in the CNS and Its Challenges; In Vivo Imaging of the CNS Following Sterile Injury; In Vivo Imaging of the CNS in Disorders with an Inflammatory Component; Conclusion; Acknowledgments; References; Part II Detrimental Aspects of Inflammation; Chapter 3 Roles of CD4 and CD8 T Lymphocytes in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis; Introduction; T Lymphocytes: Central Immune Cells; Autoreactive T LymphocytesFrom Peripheral Activation to CNS ExtravasationRole of CD4 T Lymphocytes in MS and EAE: Th1 versus Th17; Role of CD8 T Lymphocytes in MS and EAE; Regulatory T Lymphocytes in MS and EAE; Conclusions; Acknowledgments; References; Chapter 4 Microglia and Macrophage Responses and Their Role after Spinal Cord Injury; Introduction; Microglial Responses to Injury; Interactions between Microglia and Other Cell Types in Signaling Responses to Injury; Entry of Peripheral Macrophages and Differences with Microglia; Diverse Roles of Macrophages/Microglia in CNS Injury and DiseaseMacrophage Polarization in SCIConcluding Remarks; Acknowledgments; References; Chapter 5 The Complexity of the Innate Immune System Activation in Stroke Pathogenesis; Activation of the Brain Innate Immunity After Stroke; Myeloid Heterogeneity in Brain Ischemia; Concluding Remarks; References; Chapter 6 Neuroinflammation in Aging; Increased CNS Inflammation in Response to Immune Challenge is Adaptive and Beneficial; The CNS Microenvironment Shifts to a Proinflammatory State with Aging; Microglial Priming; Microglial RegulationImmune Reactivity of Glia Contributes to Cognitive and Behavioral DeficitsConclusions; References; Chapter 7 Peripheral and Central Immune Mechanisms in Neuropathic Pain; Introduction; Inflammation in Neuropathic Pain; Contribution of Peripheral Immune Cells to the Pathogenesis of Neuropathic Pain; Critical Roles of Spinal Glial Activation in Neuropathic Pain; Significance of Neural Barriers in Inflammatory Response along Pain Transmission Pathway; Imbalance of Pro- and Anti-inflammatory Responses in Neuropathic PainChallenges in Translating Anti-inflammatory Therapeutic Strategies for the Relief of~Neuropathic Pain Neuroinflammation has long been studied in its connection to the development and progression of Multiple Sclerosis. In recent years, the fied has expanded to look at the role of inflammatory processes in a wide range of neurological diseases and cognitive disorders including Alzheimer's Disease, Parkinson's and autism. Researchers have also started to appreciate the beneficial impacts of neuroinflammation in certain diseases. Neuroinflammation in the Central Nervous System looks across the discipline and provides a comprehnsive picture of the field.Neuroinflammation in the Central Nervous SysCentral nervous systemDiseasesCentral nervous systemDiseasesImmunological aspectsCentral nervous systemDiseases.Central nervous systemDiseasesImmunological aspects.616.8/0479David SamuelMiAaPQMiAaPQMiAaPQBOOK9910827392703321Neuroinflammation4043485UNINA