04530nam 2200637Ia 450 991082647170332120240417001049.00-309-18368-51-280-18544-997866101854430-309-56958-30-585-32064-0(CKB)110986584753104(OCoLC)45843189(CaPaEBR)ebrary10071320(SSID)ssj0000202003(PQKBManifestationID)11200186(PQKBTitleCode)TC0000202003(PQKBWorkID)10245955(PQKB)10282384(MiAaPQ)EBC3377297(Au-PeEL)EBL3377297(CaPaEBR)ebr10071320(CaONFJC)MIL18544(OCoLC)923269609(EXLCZ)9911098658475310420001013d2000 uy 0engurcn|||||||||txtccrMethyl bromide risk characterization in California /Subcommittee for the Review of the Risk Assessment of Methyl Bromide, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council1st ed.Washington, D.C. National Academy Press20001 online resource (111 p.) Compass series"This project was supported by Agreement No. 98-0316 between the National Academy of Sciences and the California Department of Pesticide Regulation"--T.p. verso.0-309-07087-2 Includes bibliographical references (p. 76-83).METHYL BROMIDE RISK CHARACTERIZATION IN CALIFORNIA -- Copyright -- Preface -- Contents -- Executive Summary -- THE SUBCOMMITTEE'S TASK -- THE SUBCOMMITTEE'S EVALUATION -- Toxicology -- Recommendations -- Exposure -- Recommendations -- Risk Characterization -- Recommendations -- 1 Introduction -- BACKGROUND -- CALIFORNIA REGULATIONS -- THE SUBCOMMITTEE'S TASK -- ORGANIZATION OF THE REPORT -- 2 Toxicology and Hazard Identification -- PHARMACOKINETICS -- GENOTOXICITY -- ACUTE TOXICITY -- SUBCHRONIC TOXICITY -- CHRONIC INHALATION AND ONCOGENICITY -- REPRODUCTIVE TOXICITY -- DEVELOPMENTAL TOXICITY -- NEUROTOXICITY -- SELECTION OF CRITICAL EFFECTS FOR ACUTE TOXICITY -- 3 Exposure Assessment -- BACKGROUND -- LIKELY EXPOSURE SCENARIOS -- QUALITY OF DATA AVAILABLE FOR CHARACTERIZING EXPOSURES -- Analytical Methods -- Representativeness of Available Exposure Measurements -- Appropriateness of Normalizing Assumptions for Different Application Rates -- Appropriateness of Exposure-Duration Assumptions -- ACCURACY AND APPROPRIATENESS OF AVAILABLE MODELING TOOLS -- Exposure Estimates Based on Modeling -- Exposure of Residents in a Fumigated House -- Exposure of Residents Downwind from Soil Fumigations -- SUMMARY -- 4 Risk Characterization -- RISK CHARACTERIZATION GOALS -- HAZARD IDENTIFICATION -- Acute Toxicity Database -- Subchronic Toxicity Database -- Chronic Toxicity Database -- Developmental Neurotoxicity -- EXPOSURE ASSESSMENT -- Appropriateness of Acute-Exposure Definition -- Subchronic Exposure -- Chronic Exposure -- MARGIN-OF-EXPOSURE ANALYSIS -- Categories with More than Two Data Points -- Categories with One or Two Data Points -- UNCERTAINTY ISSUES -- Derivation of Reference Concentrations -- Sensitive Subpopulations -- Multiple Exposures -- SUMMARY -- 5 Conclusions and Recommendations -- TOXICOLOGICAL INFORMATION -- Conclusions -- Recommendations.EXPOSURE ASSESSMENT -- Conclusions -- Recommendations -- RISK CHARACTERIZATION -- Conclusions -- Recommendations -- References -- Appendix A Biographical Information on the Subcommittee for the Review of the Risk Assessment of Methyl Bromide -- Appendix B Public Access Materials -- Appendix C Calculation of Air Exchange Rates -- ILLUSTRATIVE LOGNORMAL TREATMENT OF DATA FOR SELECTED OCCUPATIONAL EXPOSURES.Compass series (Washington, D.C.)BromomethaneToxicologyCaliforniaHealth risk assessmentCaliforniaBromomethaneToxicologyHealth risk assessment615.9/512National Research Council (U.S.)Subcommittee for the Review of the Risk Assessment of Methyl Bromide.MiAaPQMiAaPQMiAaPQBOOK9910826471703321Methyl bromide risk characterization in California3946342UNINA