11472nam 2200673Ia 450 991082595720332120240416235000.00-309-17281-01-280-21038-997866102103810-309-58119-20-585-13577-0(CKB)110986584752508(OCoLC)559310309(CaPaEBR)ebrary10056973(SSID)ssj0000239195(PQKBManifestationID)11191326(PQKBTitleCode)TC0000239195(PQKBWorkID)10238751(PQKB)10671264(MiAaPQ)EBC3376696(Au-PeEL)EBL3376696(CaPaEBR)ebr10056973(OCoLC)697761144(EXLCZ)9911098658475250820040925d1999 my 0engurcn|||||||||txtccrThe role of protein and amino acids in sustaining and enhancing performance /Committee on Military Nutrition Research, Committee on Body Composition, Nutrition and Health, Food and Nutrition Board, Institute of Medicine1st ed.Washington, D.C. National Academy Press19991 online resource (447 p.) Bibliographic Level Mode of Issuance: Monograph0-309-06346-9 Includes bibliographical references and index.The Role of Protein and Amino Acids in Sustaining and Enhancing Performance -- Copyright -- Preface -- HISTORY OF THE COMMITTEE -- FOCUS OF THE REPORT -- ORGANIZATION OF THE REPORT -- ACKNOWLEDGMENTS -- Contents -- Executive Summary -- COMMITTEE'S TASK -- METHODS -- FINDINGS -- Effect of Stressors on Protein Requirements of Military Personnel -- Baseline Protein and Amino Acid Requirements -- Physical Activity -- Infection, Injury, and Illness -- Other Stressors -- THE MRDA FOR PROTEIN -- Pregnancy and Lactation -- Benefits and Risks of Protein and Amino Acid Supplements and Alternative Sources of Dietary Protein -- Protein and Amino Acid Supplements and Cognitive Performance -- Protein, Amino Acids, Muscle Mass, and Physical Performance -- Protein, Amino Acids, and Immune Function -- Issues of Protein Quality and Timing of Consumption -- Dietary Protein and Renal Function -- Dietary Protein and Calcium Status -- Amino Acid Toxicity -- Protein and Amino Acid Supplements and Pregnancy -- CONCLUSIONS AND RECOMMENDATIONS -- Effects of Stressors on Protein Requirements -- Military Recommended Dietary Allowances for Protein -- Benefits and Risks of Supplemental Protein, Amine Acids, and Alternative Sources of Dietary Protein -- REFERENCES -- I Committee Summary and Recommendations -- 1 Committee Overview -- INTRODUCTION -- THE ARMY'S INTEREST IN DIETARY PROTEIN AND PROTEIN BALANCE -- ESTIMATION OF PROTEIN REQUIREMENTS -- Protein Metabolism -- Methods for Assessment of Protein Requirements -- FAO/WHO/UNU Requirements and RDAs: Current Estimates of Average Protein Intake -- Importance of the Debate over Indispensable Amino Acid Requirements -- Argument for Higher Indispensable Amine Acid Requirements -- Argument Against Higher Indispensable Amino Acid Requirements -- The Rebuttal -- Resolution of the Debate.STRESSORS THAT INFLUENCE PROTEIN REQUIREMENTS -- Physical Activity and Energy Restriction -- Exercise and Amino Acid Catabolism -- Contractile Activity and Muscle Protein Turnover -- Energy Balance and Protein Requirements -- Infection, Injury, and Illness -- Other Stressors -- Heat -- Cold and High Altitude -- Combined Stressors -- THE MRDA FOR PROTEIN -- Protein Intake Studies of Military Personnel -- Pregnancy, Lactation, and the MRDA for Protein -- Summary -- PERFORMANCE BENEFITS AND HEALTH RISKS OF SUPPLEMENTAL PROTEIN, AMINOACIDS, AND PLANT PROTEINS -- Supplement Use Among Army Personnel -- Protein and Amine Acid Supplements and Cognitive Performance -- Tryptophan -- Tyrosine -- Protein, Amino Acids, Muscle Mass, and Physical Performance -- Measurement of Muscle Mass -- Control of Muscle Mass and Function -- Hormonal Interactions -- Catabolic Hormones -- Effects of Protein, Energy, and Amine Acid Supplementation on Physical Performance -- Protein and Energy Intake in Long-Distance Cyclists -- The Fatigue Theory -- Amine Acids and Immune Function -- Issues of Protein Quality and Timing of Consumption -- Potential Benefits of Plant and Legume Proteins -- Effects of Timing of Protein Intake -- Risks Associated with High-Protein Diets and Supplements -- Protein and Renal Function -- Protein and Calcium Status -- Toxicity of Amino Acid Supplements -- REFERENCES -- 2 Responses to Questions, Conclusions, and Recommendations -- REFERENCES -- II AUTHORED PAPERS AND WORKSHOP DISCUSSIONS -- 3 Protein and Amino Acids: Physiological Optimization for Current and Future Military Operational Scenarios -- INTRODUCTION -- REFERENCES -- 4 Overview of Garrison, Field, and Supplemental Protein Intake by U.S. Military Personnel -- INTRODUCTION -- PROTEIN AVAILABILITY FROM OPERATIONAL RATIONS -- HISTORIC RATION INTAKE -- CURRENT RATION INTAKE.Energy and Protein Intakes of Military Men -- Energy and Protein Intakes of Military Women -- DETERMINATION OF PROTEIN REQUIREMENTS FOR OPERATIONAL RATIONS -- SUPPLEMENT INTAKE -- AUTHORS' CONCLUSIONS AND RECOMMENDATIONS -- REFERENCES -- 5 The Energy Costs of Protein Metabolism: Lean and Mean on Uncle Sam's Team -- ORIGIN OF THE WORD "PROTEIN -- FUNCTIONS OF BODY PROTEINS AND AMINO ACIDS -- PROTEIN METABOLISM AS AN ENERGY-REQUIRING PROCESS -- ENERGY COSTS OF PROTEIN SYNTHESIS AND REGULATION -- ENERGY COSTS OF PROTEIN BREAKDOWN -- CONCLUSION -- REFERENCES -- DISCUSSION -- 6 Regulation of Muscle Mass and Function: Effects of Aging and Hormones -- INTRODUCTION -- SARCOPENIA OF AGING -- HORMONAL EFFECTS ON MUSCLE PROTEIN -- Insulin -- Growth Hormone and IGF-I -- Sex Steroids -- CATABOLIC HORMONES (GLUCAGON, CORTISOL, EPINEPHRINE, AND THYROID HORMONES) -- SUBSTRATES AND NUTRITION -- AUTHORS' CONCLUSIONS -- REFERENCES -- DISCUSSION -- 7 Effects of Protein Intake on Renal Function and on the Development of Renal Disease -- INTRODUCTION -- NEPHROLITHIASIS -- Calcium Excretion and Calcium-Containing Stones -- Calcium Intake -- Determinants of Calcium Clearance -- Patterns of Urinary Excretion in Stone Formers -- Uric Acid Stones -- Prophylactic Treatment of Nephrolithiasis -- ACUTE RENAL FAILURE -- PROTEIN INTAKE AND THE DEVELOPMENT OF GLOMERULOSCLEROSIS -- AUTHOR'S CONCLUSIONS AND RECOMMENDATIONS -- REFERENCES -- DISCUSSION -- 8 Infection and Injury: Effects on Whole Body Protein Metabolism -- BACKGROUND AND GENERAL RESPONSE CHARACTERISTICS -- THE TRANSLOCATION OF NITROGEN FROM CARCASS TO VISCERA -- REGULATORS OF THE TRANSLOCATION OF PROTEIN -- CONCLUSIONS -- REFERENCES -- DISCUSSION -- 9 Inherent Difficulties in Defining Amino Acid Requirements -- INTRODUCTION -- BACKGROUND TO THE CURRENT CONTROVERSY -- METABOLIC BACKGROUND -- Obligatory Metabolic Demand.Obligatory Metabolic Demands and Obligatory Oxidative Losses -- Use of the Obligative Oxidative Loss Pattern to Predict a Requirement Pattern -- Animal Data for the Pattern of the Obligatory Metabolic Demand -- The Adaptive Component of the Metabolic Demand -- Diurnal Cycling: A Qualitative Influence on Metabolic Demand? -- Summary of the Metabolic Demand for Indispensable Amine Acids -- FAO REQUIREMENT VALUES AND N BALANCE STUDIES -- Are There Robust N Balance Data that Support the FAO Requirement Values? -- Biological Value of Plant Proteins in Human N Balance Trials -- Adjustment of the Food and Agriculture Organization Requirement Values -- Stable Isotope Estimates of Requirement Values -- Toronto "Break Point" Studies -- Functional Indicators of Adequacy of Intakes Allowing Zero Balance -- Protein Turnover -- Other Metabolic Influences of Amino Acids -- AUTHOR'S CONCLUSIONS AND RECOMMENDATIONS -- REFERENCES -- DISCUSSION -- 10 Amino Acid Flux and Requirements: Counterpoint -- Tentative Estimates Are Feasible and Necessary -- INTRODUCTION -- Proposed Massachusetts Institute of Technology Amine Acid Requirement Pattern -- Adaptive Aspects of Amino Acid Metabolism -- Diurnal Cycling and Amine Acid Requirements -- Nitrogen Balance and Estimations of IAA Requirements -- Stable Isotope Estimates of Requirement Values -- The MIT Amino Acid Requirement Pattern and Physical Activity -- Author's Conclusions and Recommendations -- REFERENCES -- 11 Physical Exertion, Amino Acid and Protein Metabolism, and Protein Requirements -- INTRODUCTION -- EXERCISE AND AMINO ACID CATABOLISM -- EFFECTS OF CONTRACTILE ACTIVITY ON MUSCLE PROTEIN TURNOVER -- INTERACTIONS BETWEEN ENERGY SUPPLY AND PROTEIN AND AMINE ACID METABOLISMIN THE CONTEXT OF INCREASED ... -- POSSIBLE BENEFICIAL EFFECTS OF BRANCHED CHAIN AMINO ACID SUPPLEMENTATION.GLUTAMINE, THE OVERTRAINING SYNDROME AND IMMUNE FUNCTION -- THE CRUCIAL QUESTIONS -- AUTHOR'S CONCLUSIONS AND RECOMMENDATIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 12 Skeletal Muscle Markers -- INTRODUCTION -- Method Organization -- AVAILABLE METHODS -- Anthropometry -- Ultrasound -- Bioelectric Impedance Analysis -- Urinary Metabolites -- Imaging Methods -- Dual-Energy X-Ray Absorptiometry -- In Vive Neutron Activation/Whole Body Counting -- Monitoring Changes in Skeletal Muscle Mass Over Time -- CONCLUSIONS -- REFERENCES -- 13 Alterations in Protein Metabolism Due to the Stress of Injury and Infection -- ANABOLIC HORMONES -- AUTHOR'S CONCLUSIONS AND RECOMMENDATIONS -- REFERENCES -- I DISCUSSION -- 14 Amino Acid and Protein Requirements: Cognitive Performance, Stress, and Brain Function -- INTRODUCTION -- The Blood-Brain Barrier: A Key Determinant of Brain Nutritional Status -- TRYPTOPHAN -- TYROSINE -- CHANGES IN AMINO ACIDS DURING FIELD STUDIES: UNDERNUTRITION AND MENTAL PERFORMANCE -- AUTHOR'S CONCLUSION AND RECOMMENDATIONS -- REFERENCES -- DISCUSSION -- 15 Supplementation with Branched-Chain Amino Acids, Glutamine, and Protein Hydrolysates: Rationale for Effects on ... -- INTRODUCTION -- PROTEIN AND AMINE ACID METABOLISM IN ENDURANCE EXERCISE -- BRANCHED-CHAIN AMINE ACIDS -- Central Fatigue Hypothesis -- Effects of Ingestion of Branched-Chain Amino Acids and Tryptophan on Endurance Performance -- Summary of Performance Studies with BCAA and Tryptophan -- Interaction of the BCAA-Aminotransferase Reaction with the Tricarboxylic Acid (TCA) Cycle in Muscle -- Effect of BCAA Ingestion on Plasma Ammonia Concentrations and Muscle Ammonia Production During Exercise -- GLUTAMINE -- Plasma Glutamine Concentrations Following Prolonged Exercise -- Plasma Glutamine Concentrations in Overtrained Athletes and in Tour de France Cyclists -- Link to Immune System.GLYCOGEN RESYNTHESIS FOLLOWING EXERCISE.Proteins in human nutritionAmino acids in human nutritionSoldiersUnited StatesNutritionProteins in human nutrition.Amino acids in human nutrition.SoldiersNutrition.612.3/98Institute of Medicine (U.S.).Committee on Military Nutrition Research.MiAaPQMiAaPQMiAaPQBOOK9910825957203321The role of protein and amino acids in sustaining and enhancing performance4042719UNINA