03565nam 2200769Ia 450 991082593690332120251116163834.09786612684906978128268490412826849069780470574898047057489597804705748810470574887(CKB)2550000000006396(EBL)479843(OCoLC)501316330(SSID)ssj0000359643(PQKBManifestationID)11259450(PQKBTitleCode)TC0000359643(PQKBWorkID)10307265(PQKB)10087662(MiAaPQ)EBC479843(Au-PeEL)EBL479843(CaPaEBR)ebr10360988(CaONFJC)MIL268490(PPN)243321155(OCoLC)435728364(FINmELB)ELB178839(Perlego)2759471(EXLCZ)99255000000000639620090827d2010 uy 0engur|n|---|||||txtccrEvaluation of drug candidates for preclinical development pharmacokinetics, metabolism, pharmaceutics, and toxicology /edited by Chao Han, Charles B. Davis, Binghe Wang1st ed.Hoboken, NJ John Wiley & Sonsc20101 online resource (303 p.)Wiley series in drug discovery and developmentIncludes index.9780470044919 0470044918 EVALUATION OF DRUG CANDIDATES FOR PRECLINICAL DEVELOPMENT; CONTENTS; PREFACE; CONTRIBUTORS; 1. INTRODUCTION; 2. PHARMACOKINETICS IN PRECLINICAL DRUG DEVELOPMENT: AN OVERVIEW; 3. THE ROLE OF MEMBRANE TRANSPORTERS IN DRUG DISPOSITION; 4. CYTOCHROME P450: STRUCTURE, FUNCTION, AND APPLICATION IN DRUG DISCOVERY AND DEVELOPMENT; 5. THE ROLE OF DRUG METABOLISM AND METABOLITE IDENTIFICATION IN DRUG DISCOVERY; 6. PROTEIN BINDING IN DRUG DISCOVERY AND DEVELOPMENT; 7. PREDICTION OF THE PHARMACOKINETICS IN HUMANS; 8. PHARMACEUTICS DEVELOPABILITY ASSESSMENT; 9. SAFETY ASSESSMENT IN DRUG DISCOVERY10. ASSESSMENT OF STRATEGIES UTILIZED TO MINIMIZE THE POTENTIAL FOR INDUCTION OF ACQUIRED LONG QT SYNDROME AND TORSADE DE POINTESINDEX Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation It is believed that selecting the ""right"" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADWiley series in drug discovery and development.Drug developmentPharmacokineticsDrugsMetabolismDrug development.Pharmacokinetics.DrugsMetabolism.615.19615/.19Han Chao1712234Davis Charles B(Charles Baldwin)150958Wang Binghe1962-915404MiAaPQMiAaPQMiAaPQBOOK9910825936903321Evaluation of drug candidates for preclinical development4104193UNINA