01097nam0 22002771i 450 UON0032765620231205104207.21597-390-4201-520090724d1991 |0itac50 barumRO|||| 1||||Povestile pelesuluiCarmen Sylvaed. ingr. si pref. de Tudor NedelceaCraiovaNob199197 p.20 cm.CraiovaUONL004503859Letteratura romena e letterature ladine21SYLVACarmenUONV186757700461NEDELCEATudorUONV186758NobUONV275755650ITSOL20240220RICAUON00327656SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI FONDO ONCIULESCU A 0364 SI EO 42658 5 0364 SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI FONDO ONCIULESCU A 0688 SI EO 42909 5 0688 Povestile pelesului1369089UNIOR03564nam 2200769Ia 450 991082593690332120200520144314.09786612684906978128268490412826849069780470574898047057489597804705748810470574887(CKB)2550000000006396(EBL)479843(OCoLC)501316330(SSID)ssj0000359643(PQKBManifestationID)11259450(PQKBTitleCode)TC0000359643(PQKBWorkID)10307265(PQKB)10087662(MiAaPQ)EBC479843(Au-PeEL)EBL479843(CaPaEBR)ebr10360988(CaONFJC)MIL268490(PPN)243321155(OCoLC)435728364(FINmELB)ELB178839(Perlego)2759471(EXLCZ)99255000000000639620090827d2010 uy 0engur|n|---|||||txtccrEvaluation of drug candidates for preclinical development pharmacokinetics, metabolism, pharmaceutics, and toxicology /edited by Chao Han, Charles B. Davis, Binghe Wang1st ed.Hoboken, NJ John Wiley & Sonsc20101 online resource (303 p.)Wiley series in drug discovery and developmentIncludes index.9780470044919 0470044918 EVALUATION OF DRUG CANDIDATES FOR PRECLINICAL DEVELOPMENT; CONTENTS; PREFACE; CONTRIBUTORS; 1. INTRODUCTION; 2. PHARMACOKINETICS IN PRECLINICAL DRUG DEVELOPMENT: AN OVERVIEW; 3. THE ROLE OF MEMBRANE TRANSPORTERS IN DRUG DISPOSITION; 4. CYTOCHROME P450: STRUCTURE, FUNCTION, AND APPLICATION IN DRUG DISCOVERY AND DEVELOPMENT; 5. THE ROLE OF DRUG METABOLISM AND METABOLITE IDENTIFICATION IN DRUG DISCOVERY; 6. PROTEIN BINDING IN DRUG DISCOVERY AND DEVELOPMENT; 7. PREDICTION OF THE PHARMACOKINETICS IN HUMANS; 8. PHARMACEUTICS DEVELOPABILITY ASSESSMENT; 9. SAFETY ASSESSMENT IN DRUG DISCOVERY10. ASSESSMENT OF STRATEGIES UTILIZED TO MINIMIZE THE POTENTIAL FOR INDUCTION OF ACQUIRED LONG QT SYNDROME AND TORSADE DE POINTESINDEX Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation It is believed that selecting the ""right"" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADWiley series in drug discovery and development.Drug developmentPharmacokineticsDrugsMetabolismDrug development.Pharmacokinetics.DrugsMetabolism.615.19615/.19Han Chao1712234Davis Charles B(Charles Baldwin)150958Wang BinghePhD.915404MiAaPQMiAaPQMiAaPQBOOK9910825936903321Evaluation of drug candidates for preclinical development4104193UNINA