05606nam 2200757Ia 450 991082579230332120200520144314.01-282-36851-697866123685160-470-47328-20-470-47327-4(CKB)1000000000821994(EBL)468819(OCoLC)609847549(SSID)ssj0000290886(PQKBManifestationID)11232773(PQKBTitleCode)TC0000290886(PQKBWorkID)10229957(PQKB)10639855(MiAaPQ)EBC468819(Au-PeEL)EBL468819(CaPaEBR)ebr10346015(CaONFJC)MIL236851(PPN)191675628(OCoLC)319126638(FINmELB)ELB178385(EXLCZ)99100000000082199420090420d2009 uy 0engur|n|---|||||txtccrCarbohydrate-based vaccines and immunotherapies /edited by Zhongwu Guo, Geert-Jan Boons1st ed.Hoboken, N.J. ;Oxford, [UK] Wileyc20091 online resource (436 p.)Wiley series in drug discovery and developmentDescription based upon print version of record.0-470-19756-0 Includes bibliographical references and index.CARBOHYDRATE-BASED VACCINES AND IMMUNOTHERAPIES; CONTENTS; Preface; Contributors; 1 Glycobiology and Immunology; 1.1 Introduction; 1.2 Glycobiology; 1.2.1 Glycosylation-Is It Worth the Cost?; 1.2.2 Glycan Biosynthesis-A Dauntingly Complex Process; 1.2.3 Glycoproteins; 1.2.4 Lipid-Based Glycans; 1.2.5 Polysaccharides: Glycosaminoglycans and Bacterial Capsular Components; 1.3 The Immune System; 1.3.1 Introductory Comments; 1.3.2 Overview of the Immune System; 1.3.3 Glycoimmunobiology; 1.3.4 Interplay between Glycosylation and Sugars: a Two-Way Street; 1.4 Carbohydrate Antigens1.4.1 Carbohydrate Antigens in Humans1.4.2 Carbohydrates and Pathogens; 1.4.3 Carbohydrate-Based Vaccines; 1.4.4 Concluding Comments: Building on Success; Acknowledgment; References; 2 Preparation of Glycoconjugate Vaccines; 2.1 Introduction; 2.2 Capsular Polysaccharide-Protein Conjugates; 2.2.1 Haemophilus influenzae Type b; 2.2.2 Streptococcus pneumoniae; 2.2.3 Neisseria meningitidis; 2.2.4 Salmonella typhi Vi; 2.2.5 Group B Streptococcus; 2.2.6 Staphylococcus aureus Types 5 and 8; 2.3 Lipopolysaccharide (LPS) and Lipooligosaccharide (LOS) Conjugates; 2.3.1 Escherichia coli O1572.3.2 Vibrio cholerae O1 and O1392.3.3 Shigella dysenteriae Type 1, sonnei and flexneri 2a; 2.3.4 Neisseria meningitidis and Nontypeable Haemophilus influenzae; 2.4 Total Synthetic Glycoconjugate Vaccines; References; 3 Adjuvants for Protein- and Carbohydrate-Based Vaccines; 3.1 Introduction; 3.2 Initiation and Stimulation of Adaptive Responses; 3.3 "Old" Adjuvants and Formulations; 3.3.1 Aluminum; 3.3.2 Emulsions; 3.3.3 Saponins, QS21, and ISCOMS; 3.3.4 Liposomes and Microparticles; 3.3.5 Antigen/Formulation Targeting; 3.3.6 Induction of CD8 CTLs with Soluble Antigens3.4 Renaissance of Innate Immunity3.4.1 Toll-Like Receptors: Agonists and Roles; 3.4.2 Non-TLRs Innate Receptors; 3.4.3 Other Receptors Involved in Antigen Capture and Recognition; 3.5 From Basic Research to Practical Applications: Identification of New Adjuvants; 3.5.1 TLR Synthetic Agonists; 3.5.2 Combination of PRR Agonists; 3.6 Adjuvants for Carbohydrate-Based Vaccines; 3.6.1 Td and Ti B-Cell Responses; 3.6.2 Adjuvants for "Free" Polysaccharides (Ti Antigens); 3.6.3 Adjuvants for Glycoconjugate Vaccines (T-Dependent Antigens)3.7 Combinations of Adjuvants: Preclinical and Clinical Developments3.8 Immunomodulation of Existing Responses: Adjuvants for Therapeutic Vaccines; 3.9 Take Another Route; 3.9.1 Adjuvants for Mucosal Immunization; 3.9.2 Epidermal or Intradermal Routes; 3.10 Practical Aspects of Adjuvant Development; 3.10.1 Regulatory Aspects; 3.10.2 Safety versus Efficacy: Risk-Benefit Ratio; 3.11 Preclinical Models Used in Adjuvant Development; 3.11.1 Animal Models; 3.11.2 In vitro Models; 3.12 Conclusions and Perspectives; Acknowledgment; References; 4 Carbohydrate-Based Antibacterial Vaccines4.1 IntroductionThe fundamental science and the latest developments in carbohydrate-based vaccines The relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments. With contributions by leading experts, this resource covers the design, synthesis, evaluation, and applications of vaWiley series in drug discovery and development.CarbohydratesImmunologyVaccinesGlycoconjugatesImmunologyCarbohydratesImmunology.Vaccines.GlycoconjugatesImmunology.616.07/9616.079Guo Zhongwu1655284Boons Geert-Jan877768MiAaPQMiAaPQMiAaPQBOOK9910825792303321Carbohydrate-based vaccines and immunotherapies4007607UNINA