03418nam 2200601 450 991082541410332120200520144314.01-4422-6480-2(CKB)3710000000960659(MiAaPQ)EBC4748971(Au-PeEL)EBL4748971(CaPaEBR)ebr11303153(CaONFJC)MIL972954(OCoLC)954038400(EXLCZ)99371000000096065920161209h20172017 uy 0engurcnu||||||||rdacontentrdamediardacarrierChild exploitation and trafficking examining global enforcement and supply chain challenges, and U.S. responses /Virginia M. Kendall and T. Markus Funk ; foreword by Richard A. PosnerSecond edition.Lanham, [Maryland] :Rowman & Littlefield,2017.©20171 online resource (557 pages)1-4422-6479-9 1-4422-6478-0 Includes bibliographical references and index.Introduction -- Surveying the scope of the sexual exploitation problem -- The broad descriptive challenge in sexual exploitation cases -- Appreciating the human trafficking tragedy : and its enforcement challenges -- Landmark anti-trafficking laws and regulations herald the new compliance reality for today's companies -- Synchronized abuse : the impact of international organized crime groups on child trafficking and other forms of sexual exploitation -- Public corruption as the silent partner to child sexual exploitation -- Federal statutes targeting child exploitation -- Finding the world's voice : international instruments targeting the sexual exploitation of children -- Investigating child exploitation cases -- The syndicate and the scholar : examining the anatomy of the prosecution of University of Chicago pediatrician Dr. H. Marc Watzman -- The challenge of transnational investigations -- Addressing special issues in the fight against human trafficking -- Victim witness protection in child exploitation cases -- The difficult defense : surveying the most common issues when representing individuals accused of child exploitation -- Overview of selected trial issues -- Sentencing considerations in sexual exploitation cases : does anything work?Child trafficking victimsLegal status, laws, etcUnited StatesHuman traffickingLaw and legislationUnited StatesHuman traffickingInvestigationUnited StatesChild sexual abuseUnited StatesPreventionChild trafficking victimsLegal status, laws, etcHuman traffickingInvestigationChild trafficking victimsLegal status, laws, etc.Human traffickingLaw and legislationHuman traffickingInvestigationChild sexual abusePrevention.Child trafficking victimsLegal status, laws, etc.Human traffickingInvestigation.345.73/0253Kendall Virginia M.1962-1648388Funk T. MarkusPosner Richard A.MiAaPQMiAaPQMiAaPQBOOK9910825414103321Child exploitation and trafficking3996494UNINA05483nam 22014293a 450 991036775470332120250203235431.09783039211906303921190010.3390/books978-3-03921-190-6(CKB)4100000010106170(oapen)https://directory.doabooks.org/handle/20.500.12854/61900(ScCtBLL)7f92ff81-7eac-47f9-98c7-07aa248d0431(OCoLC)1163853203(oapen)doab61900(EXLCZ)99410000001010617020250203i20192019 uu engurmn|---annantxtrdacontentcrdamediacrrdacarrierVenom and Toxin as Targeted TherapyHang Fai Henry KwokMDPI - Multidisciplinary Digital Publishing Institute2019Basel, Switzerland :MDPI,2019.1 electronic resource (180 p.)9783039211890 3039211897 Targeted therapy has developed significantly in the last one and half decades, prescribing specific medications for treatment of particular diseases, such as cancer, diabetes, and heart disease. One of the most exciting recent developments in targeted therapies was the isolation of disease-specific molecules from natural resources, such as animal venoms and plant metabolites/toxins, for use as templates for new drug motif designs. In addition, the study of venom proteins/peptides and toxins naturally targeted mammalian receptors and demonstrated high specificity and selectivity towards defined ion channels of cell membranes. Research has also focsed intensely on receptors. The focus of this Special Issue of Toxins addressed the most recent advances using animal venoms, such as frog secretions, bee/ant venoms and plant/fungi toxins, as medicinal therapy. Recent advances in venom/toxin/immunotoxins for targeted cancer therapy and immunotherapy, along with using novel disease-specific venom-based protein/peptide/toxin and currently available FDA-approved drugs for combinationtreatments will be discussed. Finally, we included an overview of select promising toad/snake venom-based peptides/toxins potentially able to address the forthcoming challenges in this field. Both research and review articles proposing novelties or overviews, respectively, were published in this Special Issue after rigorous evaluation and revision by expert peer reviewers.Biology, life sciencesbicssccane toadB cell non-Hodgkin lymphomaMalaysian cobrascomplement systemdecay accelerating factorneuroblastomaatopic dermatitiscomplement dependent cytotoxicityantioxidant enzymesbacterial adhesioncancer therapyN. kaouthiaanuran skin secretionfrogApis mellifera syriacasolid phase extractionbee venom phospholipase A2 (bvPLA2)disintegrintoad toxinsimmunotoxinsribosome-inactivating proteinsantimicrobial peptide (AMP)drug designMoxetumomab pasudotoxsnake venomantiviral activityin vitro effectsbombesin-related peptideoxidative stress biomarkershalf-lifeblood vessel formationtarget therapy2MYCNindolealkylaminesHuachansumembrane attack complexbouganinbee venomSEManticancer activityantimicrobial peptidehouse dust mite extract (DFE)mannose receptorO. hannahbicarinalingastric cellsmelittinLC-ESI-MSdermaseptinsmooth muscleapoptosisanticancerN. sumatranaHelicobacter pyloriinflammationimmunotherapyatopic dermatitis (AD)immunotoxinmantle cell lymphomaclearancemass spectrometryBougainvillearRNA N-glycosylase activityfungal toxinskin inflammationtargeted therapy4-dinitrochlorobenzene (DNCB)Bee venomVEGFChansubufadienolidesobsessive-compulsive disorder (OCD)BLF1antimicrobial activityorellanineVB6-845acute lymphoblastic leukemiaribosome-inactivating proteinCD206molecular cloningcancerCD22eIF4ABiology, life sciencesKwok Hang Fai Henry1320455ScCtBLLScCtBLLBOOK9910367754703321Venom and Toxin as Targeted Therapy3034329UNINA