02997nam 2200733Ia 450 991082453560332120200520144314.01-282-77308-997866127730820-470-66140-20-470-66139-9(CKB)2670000000044923(EBL)589257(OCoLC)690877019(SSID)ssj0000422356(PQKBManifestationID)11289422(PQKBTitleCode)TC0000422356(PQKBWorkID)10418924(PQKB)11437043(MiAaPQ)EBC589257(Au-PeEL)EBL589257(CaPaEBR)ebr10412599(CaONFJC)MIL277308(OCoLC)495598260(FINmELB)ELB178604(EXLCZ)99267000000004492320091229d2010 uy 0engur|n|---|||||txtccrLow-dimensional solids /edited by Duncan W. Bruce, Dermot O'Hare, Richard I. Walton1st ed.Hoboken, N.J. Wiley20101 online resource (310 p.)Inorganic materials seriesDescription based upon print version of record.0-470-99751-6 Includes bibliographical references and index.Low-Dimensional Solids; Contents; Inorganic Materials Series Preface; Preface; List of Contributors; 1 Metal Oxide Nanoparticles; 2 Inorganic Nanotubes and Nanowires; 3 Biomedical Applications of Layered Double Hydroxides; 4 Carbon Nanotubes and Related Structures; 5 Magnesium Diboride MgB2: A Simple Compound with Important Physical Properties; IndexWith physical properties that often may not be described by the transposition of physical laws from 3D space across to 2D or even 1D space, low-dimensional solids exhibit a high degree of anisotropy in the spatial distribution of their chemical bonds. This means that they can demonstrate new phenomena such as charge-density waves and can display nanoparticulate (0D), fibrous (1D) and lamellar (2D) morphologies. This text presents some of the most recent research into the synthesis and properties of these solids and covers:Metal Oxide NanoparticlesInorganic Nanotubes and NanowiresInorganic materials.NanotubesNanowiresMetallic oxidesInorganic compoundsSuperconducting compositesNanotubes.Nanowires.Metallic oxides.Inorganic compounds.Superconducting composites.620/.5Bruce Duncan W861136O'Hare Dermot861137Walton Richard I107204MiAaPQMiAaPQMiAaPQBOOK9910824535603321Low-dimensional solids4118246UNINA02803nam 22004935 450 991034944570332120200703082634.0981-329-267-910.1007/978-981-32-9267-3(CKB)4100000009152993(MiAaPQ)EBC5889019(DE-He213)978-981-32-9267-3(PPN)242824277(EXLCZ)99410000000915299320190830d2019 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierSIRT6 Activities in DNA Damage Repair and Premature Aging Functions of SIRT6 /by Shrestha Ghosh1st ed. 2019.Singapore :Springer Singapore :Imprint: Springer,2019.1 online resource (188 pages)Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053"Doctoral thesis accepted by The University of Hong Kong, Hong Kong, China"--Title page.981-329-266-0 Introduction -- Materials and Methods -- Results-I. Lamin A is an endogenous activator of SIRT6 in DNA damage repair process -- Results-II. Haploinsufficiency of p53 rescues lifespan and premature aging-associated abnormalities in Sirt6-deficient mice -- Results-III. SIRT6 is an acetylated protein and a NAD+-dependent self-deacetylase -- Discussion.This book illustrates the activities of mammalian sirtuin SIRT6 in connection with DNA damage repair and premature aging. It mainly presents research on the nuclear lamin A, notably the upregulation of p53 and acetylation etc. Taken together, these studies reveal the various regulatory roles of SIRT6, which are of substantial biological relevance in DNA damage repair, aging and longevity, and can have significant implications in devising therapeutic strategies to combat age-associated pathologies. Given its scope, the book offers a valuable resource for students and researchers in the fields of genetics, cell biology, molecular biology etc.Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053Human geneticsCytologyHuman Geneticshttps://scigraph.springernature.com/ontologies/product-market-codes/B12008Cell Biologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L16008Human genetics.Cytology.Human Genetics.Cell Biology.572.86459Ghosh Shresthaauthttp://id.loc.gov/vocabulary/relators/aut963288BOOK9910349445703321SIRT6 Activities in DNA Damage Repair and Premature Aging2184141UNINA