03197nam 2200733 450 991082347650332120231110214129.01-119-95207-71-118-52607-41-118-52601-51-118-52606-6(CKB)2550000001256700(EBL)1662189(SSID)ssj0001180119(PQKBManifestationID)11707588(PQKBTitleCode)TC0001180119(PQKBWorkID)11199478(PQKB)11649907(MiAaPQ)EBC1662189(MiAaPQ)EBC4036073(DLC) 2013049079(Au-PeEL)EBL1662189(CaPaEBR)ebr10856814(OCoLC)875820294(MiAaPQ)EBC7103769(Au-PeEL)EBL7103769(JP-MeL)3000111210(EXLCZ)99255000000125670020140414h20142014 uy 0engur|n|---|||||txtccrMolecular and cellular toxicology an introduction /Dr. Lesley A. StanleyChichester, England :Wiley Blackwell,2014.20141 online resource (435 p.)New York Academy of Sciences Includes bibliographical references and index1-119-95206-9 1-306-57172-3 Includes bibliographical references at the end of each chapters and index.Background to molecular and cellular toxicology -- Individual susceptibility to toxic chemicals -- Omics techniques -- In vitro methods for predicting in vivo toxicity -- In vitro methods for absorption, distribution, metabolism and excretion -- In silico methods and structure-activity relationships -- Transgenic animal models for ADME and systemic toxicity -- Genotoxicity and its measurement -- Oncogenes and the identification of human carcinogens -- Emerging techniques.Toxicology is the study of the adverse effects of chemical, physical, or biological agents on people, animals, and the environment. Toxicologists are trained to investigate, interpret, and communicate the nature of those effects. Over the last ten years the subject of toxicology has changed dramatically, moving from a discipline which was once firmly wedded to traditional methods to one which is keen to embrace the innovative techniques emerging from the developing fields of cell culture and molecular biology. There is an acute need for this to be reflected in a paradigm shift whichNew York Academy of Sciences Toxicity testingMethodsMolecular biologyXenobioticstoxicityToxicity testingMolecular biology.Xenobioticstoxicity.615.9/07491.59njb/09QV 602njb/09615.9/07njb/09Stanley Lesley1612512MiAaPQMiAaPQMiAaPQBOOK9910823476503321Molecular and cellular toxicology3941352UNINA