03848nam 2200757 a 450 991082262870332120200520144314.01-281-30751-3978661130751692-4-068249-X(CKB)1000000000689235(EBL)329002(OCoLC)213772601(SSID)ssj0000294931(PQKBManifestationID)12071167(PQKBTitleCode)TC0000294931(PQKBWorkID)10315392(PQKB)10095882(MiAaPQ)EBC329002(Au-PeEL)EBL329002(CaPaEBR)ebr10214528(CaONFJC)MIL130751(EXLCZ)99100000000068923520081023d2006 uy 0engur|n|---|||||txtccrElemental speciation in human health risk assessment /first draft prepared by P. Apostoli ... [et al.]1st ed.Geneva World Health Organization20061 online resource (256 p.)Environmental health criteria,0250-863X ;234"Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals."92-4-157234-5 Includes bibliographical references and index.TITLE; COPYRIGHT; CONTENTS; NOTE TO READERS OF THE CRITERIA MONOGRAPHS; PREAMBLE; WHO TASK GROUP ON ENVIRONMENTAL HEALTH CRITERIA FOR ELEMENTAL SPECIATION IN HUMAN HEALTH RISK ASSESSMENT; ACRONYMS AND ABBREVIATIONS; 1. SUMMARY; 2. DEFINITIONS OF SPECIES AND SPECIATION; 3. STRUCTURAL ASPECTS OF SPECIATION; 4. ANALYTICAL TECHNIQUES AND METHODOLOGY; 5. BIOACCESSIBILITY AND BIOAVAILABILITY; 6. TOXICOKINETICS AND BIOLOGICAL MONITORING; 7. MOLECULAR AND CELLULAR MECHANISMS OF METAL TOXICITY; 8. HEALTH EFFECTS; 9. CONCLUSIONS AND RECOMMENDATIONS; REFERENCES; RESUME; RESUMEN; INDEX OF ELEMENTS; The purpose of this book is to assess, evaluate, and give guidance on the role of elemental speciation and speciation analysis in human health hazard and risk assessment. The book is directed at risk assessors and regulators, to emphasize the importance of consideration of speciation in their deliberations. To date, this issue has not been a part of most hazard and risk assessments. Further aims of the publication are to encourage the analysis of speciation of elements to increase knowledge on the effect of speciation on mode of action and to increase understanding of health effects.Environmental health criteria ;234.Trace elementsSpeciationHealth risk assessmentBiological monitoringBioavailabilityAnalytical toxicologyChemical elementsPhysiological effectTrace elementsSpeciation.Health risk assessment.Biological monitoring.Bioavailability.Analytical toxicology.Chemical elementsPhysiological effect.615.9515Apostoli P(Pietro)1661493International Program on Chemical Safety.World Health Organization.United Nations Environment Programme.International Labour Organisation.Inter-Organization Programme for the Sound Management of Chemicals.MiAaPQMiAaPQMiAaPQBOOK9910822628703321Elemental speciation in human health risk assessment4017431UNINA