03312nam 2200673 450 991082239770332120200520144314.01-118-55351-91-118-55348-91-118-55349-7(CKB)2550000001115811(EBL)1380164(OCoLC)862821788(SSID)ssj0000981892(PQKBManifestationID)11505176(PQKBTitleCode)TC0000981892(PQKBWorkID)10983972(PQKB)11002966(MiAaPQ)EBC1380164(DLC) 2012048991(Au-PeEL)EBL1380164(CaPaEBR)ebr10763007(CaONFJC)MIL516146(PPN)221587853(EXLCZ)99255000000111581120121206d2014 uy 0engur|n|---|||||txtccrMetal-based neurodegeneration from molecular mechanisms to therapeutic strategies /Robert Crichton and Roberta WardSecond edition.Chichester, West Sussex, U.K. :Wiley,2014.1 online resource (439 p.)Description based upon print version of record.1-119-97714-2 1-299-84895-8 Includes bibliographical references and index.Brain function, physiology, and the blood-brain barrier -- Role of metal ions in brain function, metal transport, storage, and homeostasis -- Immune system and neuroinflammation -- Oxidative stress in neurodegenerative diseases -- Aging and mild cognitive impairment, MCI -- Parkinson's disease -- Alzheimer's disease -- Huntington's disease and polyglutamine expansion neurodegenerative diseases -- Friedreich's ataxia and diseases associated with expansion of non-coding triplets -- Creutzfeldt-Jakob and other prion diseases -- Amyotropic lateral sclerosis -- Alcoholic brain damage -- Other neurological diseases -- Therapeutic strategies to combat the onset and progression of neurological diseases.Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies. Metal-based Neurodegeneration presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scientBrainPathophysiologyMetalsHealth aspectsNervous systemDegenerationEtiologyOxidative stressBrainPathophysiology.MetalsHealth aspects.Nervous systemDegenerationEtiology.Oxidative stress.616.8/0471Crichton Robert R520760Ward Roberta J1687622MiAaPQMiAaPQMiAaPQBOOK9910822397703321Metal-based neurodegeneration4061235UNINA