04450nam 22007094a 450 991082199750332120200520144314.09780471531995978661036785697812803678541280367857978047034293004703429359780471531999047153199597804715319750471531979(CKB)111087027117256(EBL)470024(OCoLC)54360519(SSID)ssj0000102910(PQKBManifestationID)11138337(PQKBTitleCode)TC0000102910(PQKBWorkID)10061033(PQKB)10262394(MiAaPQ)EBC470024(Au-PeEL)EBL470024(CaPaEBR)ebr10114048(CaONFJC)MIL36785(Perlego)2750669(EXLCZ)9911108702711725620030625d2004 uy 0engur|n|---|||||txtrdacontentcrdamediacrrdacarrierAnalysis and purification methods in combinatorial chemistry /edited by Bing Yan1st ed.Hoboken, N.J. Wiley-Interscience20041 online resource (xiii, 466 pages) illustrationsChemical analysis ;v. 163Description based upon print version of record.9780471269298 0471269298 Includes bibliographical references and index.Analysis and Purification Methods in Combinatorial Chemistry; CONTENTS; PREFACE; CONTRIBUTORS; PART I ANALYSIS FOR FEASIBILITY AND OPTIMIZATION OF LIBRARY SYNTHESIS; CHAPTER 1 QUANTITATIVE ANALYSIS IN ORGANIC SYNTHESIS WITH NMR SPECTROSCOPY; CHAPTER 2 (19)F GEL-PHASE NMR SPECTROSCOPY FOR REACTION MONITORING AND QUANTIFICATION OF RESIN LOADING; CHAPTER 3 THE APPLICATION OF SINGLE-BEAD FTIR AND COLOR TEST FOR REACTION MONITORING AND BUILDING BLOCK VALIDATION IN COMBINATORIAL LIBRARY SYNTHESIS; CHAPTER 4 HR-MAS NMR ANALYSIS OF COMPOUNDS ATTACHED TO POLYMER SUPPORTSCHAPTER 5 MULTIVARIATE TOOLS FOR REAL-TIME MONITORING AND OPTIMIZATION OF COMBINATORIAL MATERIALS AND PROCESS CONDITIONS; CHAPTER 6 MASS SPECTROMETRY AND SOLUBLE POLYMERIC SUPPORT; PART II HIGH-THROUGHPUT ANALYSIS FOR LIBRARY QUALITY CONTROL; CHAPTER 7 HIGH-THROUGHPUT NMR TECHNIQUES FOR COMBINATORIAL CHEMICAL LIBRARY ANALYSIS; CHAPTER 8 MICELLAR ELECTROKINETIC CHROMATOGRAPHY AS A TOOL FOR COMBINATORIAL CHEMISTRY ANALYSIS: THEORY AND APPLICATIONS; CHAPTER 9 CHARACTERIZATION OF SPLIT-POOL ENCODED COMBINATORIAL LIBRARIES; PART III HIGH-THROUGHPUT PURIFICATION TO IMPROVE LIBRARY QUALITYCHAPTER 10 STRATEGIES AND METHODS FOR PURIFYING ORGANIC COMPOUNDS AND COMBINATORIAL LIBRARIES; CHAPTER 11 HIGH-THROUGHPUT PURIFICATION: TRIAGE AND OPTIMIZATION; CHAPTER 12 PARALLEL HPLC IN HIGH-THROUGHPUT ANALYSIS AND PURIFICATION; PART IV ANALYSIS FOR COMPOUND STABILITY AND DRUGABILITY; CHAPTER 13 ORGANIC COMPOUND STABILITY IN LARGE, DIVERSE PHARMACEUTICAL SCREENING COLLECTION; CHAPTER 14 QUARTZ CRYSTAL MICROBALANCE IN BIOMOLECULAR RECOGNITION; CHAPTER 15 HIGH-THROUGHPUT PHYSICOCHEMICAL PROFILING: POTENTIAL AND LIMITATIONS; CHAPTER 16 SOLUBILITY IN THE DESIGN OF COMBINATORIAL LIBRARIES; CHAPTER 17 HIGH-THROUGHPUT DETERMINATION OF LOG D VALUES BY LC/MS METHODINDEXQuality measurement, control, and improvement in combinatorial chemistryCombinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and purification technologies must be further developed to ensure combinatorial libraries are ""purifiable,"" and ""drugable.""To this end, Analysis and Purification Methods in Combinatorial ChemistryChemical analysis ;v. 163.Combinatorial chemistryCombinatorial chemistry.615/.19Yan Bing366894MiAaPQMiAaPQMiAaPQBOOK9910821997503321Analysis and purification methods in combinatorial chemistry4192163UNINA