01200nam 2200409 450 991081934700332120230808202555.01-77258-050-3(CKB)3830000000058705(MiAaPQ)EBC5598306(MiAaPQ)EBC6151319(EXLCZ)99383000000005870520200818d2016 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierĀzādī sexual politics and postcolonial worlds /Tara AtluriBradford, Ontario :Demeter Press,[2016]©20161 online resource (viii, 349 pages)1-926452-99-2 Includes bibliographical references.Sex crimesPolitical aspectsIndiaWomenCrimes againstIndiaSex crimesPolitical aspectsWomenCrimes against364.15320954Atluri Tara1979-1665517MiAaPQMiAaPQMiAaPQBOOK9910819347003321Āzādī4024179UNINA04468nam 22006855 450 991029860510332120250609110820.03-319-74920-X10.1007/978-3-319-74920-4(CKB)4100000002892365(MiAaPQ)EBC5440577(DE-He213)978-3-319-74920-4(PPN)225548658(MiAaPQ)EBC5589150(EXLCZ)99410000000289236520180315d2018 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierMultifunctional Gold Nanostars for Cancer Theranostics /by Yang Liu1st ed. 2018.Cham :Springer International Publishing :Imprint: Springer,2018.1 online resource (83 pages)Springer Theses, Recognizing Outstanding Ph.D. Research,2190-50533-319-74919-6 Introduction -- Multifunctional GNS nanoprobe development and characterization -- In vivo evaluation of GNS nanoprobe -- GNS toxicity investigation -- Sensitive brain tumor detection using GNS nanoprobe -- Photoimmunotherapy for cancer metastasis treatment -- Conclusion and future outlook.This thesis presents the development of theranostic gold nanostars (GNS) for multimodality cancer imaging and therapy. Furthermore, it demonstrates that a novel two-pronged treatment, combining immune-checkpoint inhibition and GNS-mediated photothermal nanotherapy, can not only eradicate primary treated tumors but also trigger immune responses to treat distant untreated tumors in a mouse animal model. Cancer has become a significant threat to human health with more than eight million deaths each year, and novel methods for cancer management to improve patients’ overall survival are urgently needed. The developed multifunctional GNS nanoprobe with tip-enhanced plasmonics in the near-infrared region can be combined with (1) surface-enhanced Raman spectroscopy (SERS), (2) two-photon photoluminescence (TPL), (3) X-ray computed tomography (CT), (4) magnetic resonance imaging (MRI), (5) positron emission tomography (PET), and (6) photothermal therapy (PTT) for cancer imaging and treatment. The ability of the GNS nanoprobe to detect submillimeter intracranial brain tumors was demonstrated using PET scan – a superior non-invasive imaging modality – in a mouse animal model. In addition, delayed rechallenge with repeated cancer cell injection in cured mice did not lead to new tumor formation, indicating generation of a memorized immune response to cancer. The biocompatible gold nanostars with superior capabilities for cancer imaging and treatment have great potential for translational medicine applications.Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053NanochemistryCancerResearchBiomaterialsSpectrum analysisBiomedical engineeringPharmaceutical chemistryNanochemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C33000Cancer Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/B11001Biomaterialshttps://scigraph.springernature.com/ontologies/product-market-codes/Z13000Spectroscopy/Spectrometryhttps://scigraph.springernature.com/ontologies/product-market-codes/C11020Biomedical Engineering and Bioengineeringhttps://scigraph.springernature.com/ontologies/product-market-codes/T2700XMedicinal Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C28000Nanochemistry.CancerResearch.Biomaterials.Spectrum analysis.Biomedical engineering.Pharmaceutical chemistry.Nanochemistry.Cancer Research.Biomaterials.Spectroscopy/Spectrometry.Biomedical Engineering and Bioengineering.Medicinal Chemistry.616.99406Liu Yangauthttp://id.loc.gov/vocabulary/relators/aut651655BOOK9910298605103321Multifunctional Gold Nanostars for Cancer Theranostics1564864UNINA