04586nam 2200793 a 450 991081903770332120240516065008.09786613694324978128078393712807839319780470720585047072058197804707182610470718269(CKB)1000000000688127(EBL)703897(OCoLC)797918458(SSID)ssj0000926872(PQKBManifestationID)11559803(PQKBTitleCode)TC0000926872(PQKBWorkID)10899755(PQKB)11251924(SSID)ssj0000715467(PQKBManifestationID)11956100(PQKBTitleCode)TC0000715467(PQKBWorkID)10703731(PQKB)11525710(MiAaPQ)EBC703897(Au-PeEL)EBL703897(CaPaEBR)ebr10575687(CaONFJC)MIL369432(Perlego)2773752(EXLCZ)99100000000068812719800512d1980 uy 0engur|n|---|||||txtrdacontentcrdamediacrrdacarrierProtein degradation in health and disease1st ed.Amsterdam ;New York :Excerpta Medica,1980.1 online resource (430 pages) illustrationsCiba Foundation symposium ;75 (new ser.)Description based upon print version of record.9780470663868 0470663863 9780444901484 0444901485 Includes bibliographical references and indexes.Protein Degradation in Health and Disease; Contents; Discussion; Introduction: the classification of proteinases; Discussion; Lysosomal cysteine proteinases; Discussion; Cathepsin D: the lysosomal aspartic proteinase; Discussion; Human leucocyte elastase and cathepsin G: structural and functional characteristics; Discussion; Human collagenases: comparative and immunolocalization studies; Discussion; Proteinases in connective tissue breakdown; Discussion; Cellular mechanisms of proteinase release from inflammatory cells and the degradation of extracellular proteins; DiscussionInactivation of cytosol enzymes by a liver membrane protein; Discussion; Lysosomes and protein degradation; Discussion; Insights into mechanisms of intracellular protein turnover from studies on pinocytosis; Discussion; Turnover and degradation of mitochondria and their proteins; Discussion; Protein degradation in cells in culture; Discussion; Regulation of protein breakdown in hepatocyte monolayers; Discussion; A possible role for neutral proteolysis in the degradation of intracellular proteins; Discussion; Studies of the ATP dependence of protein degradation in cells and cell extractsDiscussion; Coordination of protein synthesis and degradation; Discussion; General discussion Sites of protein degradation; Application of liver perfusion as an in vitro model in studies of intracellular protein degradation; Protein degradation and the regulation of protein balance in muscle; Discussion; Protein degradation in metabolic and nutritional disorders; Discussion; Proteinase inhibitors in severe inflammatory processes (septic shock and experimental endotoxaemia): biochemical, pathophysiological and therapeutic aspects; Discussion; Neutral proteinases of leucocytes and the inflammatory process; Discussion; Final general discussion; Concluding remarks; Index of contributors; Subject indexThe Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world. Ciba Foundation symposium ;new ser. 75.ProteinsMetabolismCongressesProteolytic enzymesCongressesPhysiology, PathologicalCongressesProteinsMetabolismProteolytic enzymesPhysiology, Pathological616.3/995MiAaPQMiAaPQMiAaPQBOOK9910819037703321Protein degradation in health and disease2205631UNINA