05743nam 2200805Ia 450 991081846750332120260109215225.09786612548574978128254857212825485739780470556757047055675797804705567400470556749(CKB)2670000000014399(EBL)510131(SSID)ssj0000359264(PQKBManifestationID)11269262(PQKBTitleCode)TC0000359264(PQKBWorkID)10383944(PQKB)10552874(Au-PeEL)EBL510131(CaPaEBR)ebr10380955(CaONFJC)MIL254857(PPN)149154445(CaSebORM)9780470180938(MiAaPQ)EBC510131(OCoLC)612330792(OCoLC)837732271(OCoLC)ocn837732271(FINmELB)ELB178825(Perlego)2758501(EXLCZ)99267000000001439920090728d2010 uy| 0engur|n|---|||||txtccrElements of computational systems biology /edited by Huma M. Lodhi, Stephen H. Muggleton1st editionOxford Wileyc20101 online resource (435 p.)Wiley series in bioinformaticsDescription based upon print version of record.9780470180938 0470180935 Includes bibliographical references and index.ELEMENTS OF COMPUTATIONAL SYSTEMS BIOLOGY; CONTENTS; PREFACE; CONTRIBUTORS; PART I OVERVIEW; 1 Advances in Computational Systems Biology; 1.1 Introduction; 1.2 Multiscale Computational Modeling; 1.3 Proteomics; 1.4 Computational Systems Biology and Aging; 1.5 Computational Systems Biology in Drug Design; 1.6 Software Tools for Systems Biology; 1.7 Conclusion; References; PART II BIOLOGICAL NETWORK MODELING; 2 Models in Systems Biology: The Parameter Problem and the Meanings of Robustness; 2.1 Introduction; 2.2 Models as Dynamical Systems; 2.2.1 Continuous Models; 2.2.2 Discrete Models2.3 The Parameter Problem2.3.1 Parameterphobia; 2.3.2 Measuring and Calculating; 2.3.3 Counter Fitting; 2.3.4 Beyond Fitting; 2.4 The Landscapes of Dynamics; 2.4.1 Qualitative Dynamics; 2.4.2 Steady State Attractors of ODE Models; 2.5 The Meanings of Robustness; 2.5.1 Parameter Biology; 2.5.2 Robustness to Initial Conditions; 2.5.3 Robustness in Reality; 2.5.4 Structural Stability; 2.5.5 Classifying Robustness; 2.6 Conclusion; References; 3 In Silico Analysis of Combined Therapeutics Strategy for Heart Failure; 3.1 Introduction; 3.2 Materials and Methods3.2.1 Model Construction and Validation3.2.2 Classification of Different Heart Failure Cases; 3.2.3 Simulation Protocol; 3.3 Results; 3.3.1 β-Adrenergic Receptor Antagonists; 3.3.2 β-Adrenergic Receptor Kinase Inhibitor; 3.3.3 Phosphodiesterase Inhibitor; 3.3.4 Combined Therapies; 3.4 Discussion; Acknowledgment; 3A.1 Appendix; 3A.1.1 Model Validation; 3A.1.2 The Mathematical Model Used for Simulations; References; 4 Rule-Based Modeling and Model Refinement; 4.1 Kappa, Briefly; 4.2 Refinement, Practically; 4.2.1 A Simple Cascade; 4.2.2 Another Cascade; 4.2.3 The SSA Convention4.2.4 A Less Obvious Refinement4.3 Rule-Based Modeling; 4.3.1 Notation; 4.3.2 Objects and Arrows; 4.3.3 Extensions; 4.3.4 Actions and Rules; 4.3.5 Events and Probabilities; 4.4 Refinement, Theoretically; 4.4.1 Growth Policies; 4.4.2 Simple Growth Policies; 4.4.3 Neutral Refinements; 4.4.4 Example Concluded; 4.4.5 Growth Policies, Concretely; 4.4.6 A Weakly Homogeneous Refinement; 4.4.7 Nonhomogeneous Growth Policies; 4.5 Conclusion; References; 5 A (Natural) Computing Perspective on Cellular Processes; 5.1 Natural Computing and Computational Biology; 5.2 Membrane Computing5.3 Formal Languages Preliminaries5.4 Membrane Operations with Peripheral Proteins; 5.5 Membrane Systems with Peripheral Proteins; 5.5.1 Dynamics of the System; 5.5.2 Reachability in Membrane Systems; 5.6 Cell Cycle and Breast Tumor Growth Control; 5.6.1 Cell Cycle Progression Inhibition in G1/S; 5.6.2 Cell-Cycle Progression Inhibition in G2/M; References; 6 Simulating Filament Dynamics in Cellular Systems; 6.1 Introduction; 6.2 Background: The Roles of Filaments within Cells; 6.2.1 The Actin Network; 6.2.2 Intermediate Filaments; 6.2.3 Microtubules; 6.3 Examples of Filament Simulations6.3.1 Actin-Based Motility in ListeriaGroundbreaking, long-ranging research in this emergent field that enables solutions to complex biological problems Computational systems biology is an emerging discipline that is evolving quickly due to recent advances in biology such as genome sequencing, high-throughput technologies, and the recent development of sophisticated computational methodologies. Elements of Computational Systems Biology is a comprehensive reference covering the computational frameworks and techniques needed to help research scientists and professionals in computer science, biology, chemistry, pharmaceuticaWiley series on bioinformatics.Systems biologyComputational biologySystems biology.Computational biology.570.285Lodhi Huma M1640712Muggleton Stephen1640713MiAaPQMiAaPQMiAaPQBOOK9910818467503321Elements of computational systems biology3984377UNINA