05636nam 2200793Ia 450 991081846650332120200520144314.0978661254780597812825478031282547801978047060012204706001289780470600115047060011X(CKB)2670000000014363(EBL)510095(OCoLC)612342354(SSID)ssj0000356931(PQKBManifestationID)11275006(PQKBTitleCode)TC0000356931(PQKBWorkID)10350950(PQKB)11226430(MiAaPQ)EBC510095(Au-PeEL)EBL510095(CaPaEBR)ebr10375618(CaONFJC)MIL254780(PPN)198234155(OCoLC)648730670(FINmELB)ELB178881(Perlego)2752374(EXLCZ)99267000000001436320090923d2010 uy 0engurcn|||||||||txtccrBacterial population genetics in infectious disease /edited by D. Ashley Robinson, Daniel Falush, Edward J. Feil1st ed.Hoboken, N.J. J. Wileyc20101 online resource (448 p.)Description based upon print version of record.9780470424742 0470424745 Includes bibliographical references and index.Bacterial Population Genetics in Infectious Disease; Contents; Foreword; Preface; Contributors; Part I: Concepts and Methods in Bacterial Population Genetics; Chapter 1: The Coalescent of Bacterial Populations; 1.1 BACKGROUND AND MOTIVATION; 1.2 POPULATION REPRODUCTION MODELS; 1.3 TIME AND THE EFFECTIVE POPULATION SIZE; 1.4 THE GENEALOGY OF A SAMPLE OF SIZE n; 1.5 FROM COALESCENT TIME TO REAL TIME; 1.6 MUTATIONS; 1.7 DEMOGRAPHY; 1.8 RECOMBINATION AND GENE CONVERSION; 1.9 SUMMARY; REFERENCES; Chapter 2: Linkage, Selection, and the Clonal Complex; 2.1 INTRODUCTION-HISTORICAL OVERVIEW2.2 RECOMBINATION, LINKAGE, AND SUBSTRUCTURE 2.3 NEUTRALITY VERSUS SELECTION; 2.4 CLUSTERING TECHNIQUES; REFERENCES; Chapter 33: Sequence-Based Analysis of Bacterial Population Structures; 3.1 INTRODUCTION; 3.2 ALIGNMENTS; 3.3 PHYLOGENETIC METHODS; 3.4 MEASURES OF UNCERTAINTY; 3.5 BEYOND THE TREE MODEL; REFERENCES; Chapter 4: Genetic Recombination and Bacterial Population Structure; 4.1 INTRODUCTION; 4.2 CONSTRAINTS ON LGT; 4.3 INFLUENCES OF LGT ON SEQUENCE ANALYSES; 4.4 THE DETECTION OF INDIVIDUAL LGT EVENTS; 4.5 THE ESTIMATION OF HOMOLOGOUS RECOMBINATION RATES4.6 PROPERLY ACCOUNTING FOR LGT DURING SEQUENCE ANALYSES 4.7 QUESTIONS RELATING DIRECTLY TO LGT; REFERENCES; Chapter 5: Statistical Methods for Detecting the Presence of Natural Selection in Bacterial Populations; 5.1 INTRODUCTION; 5.2 NATURAL SELECTION; 5.3 STATISTICAL METHODS FOR DETECTING THE PRESENCE OF NATURAL SELECTION; 5.4 STATISTICAL METHODS FOR BACTERIAL POPULATIONS; 5.5 AN EXAMPLE; 5.6 DISCUSSION AND PERSPECTIVE; REFERENCES; Chapter 6: Demographic Influences on Bacterial Population Structure; 6.1 BACTERIAL POPULATION SIZE; 6.2 MEASURES OF GENETIC DIVERSITY6.3 THE CONCEPT OF EFFECTIVE POPULATION SIZE 6.4 INFERRING PAST DEMOGRAPHY FROM GENETIC SEQUENCE DATA; 6.5 POPULATION SUBDIVISION; 6.6 WHAT IS A BACTERIAL POPULATION?; 6.7 CONCLUSION; REFERENCES; Chapter 7: Population Genomics of Bacteria; 7.1 INTRODUCTION; 7.2 CLASSICAL BACTERIAL POPULATION GENETICS; 7.3 THE GENOMICS ERA; 7.4 BACTERIAL POPULATION GENOMICS; 7.5 NEXT-GEN BACTERIAL POPULATION GENOMICS; 7.6 NEXT-GEN GENOMICS TECHNOLOGY; 7.7 NEXT-GEN GENOMIC DATA ANALYSIS; 7.8 CONCLUSIONS/FUTURE PROSPECTS; REFERENCESChapter 8: The Use of MLVA and SNP Analysis to Study the Population Genetics of Pathogenic Bacteria 8.1 INTRODUCTION; 8.2 MLVA AND OTHER DNA FRAGMENT-BASED METHODS; 8.3 SNP AND DNA SEQUENCE-BASED METHODS; 8.4 CONCLUSION; REFERENCES; Part II: Population Genetics of Select Bacterial Pathogens; Chapter 9: Population Genetics of Bacillus :Phylogeography of Anthraxin North America; 9.1 INTRODUCTION; 9.2 HISTORY OF ANTHRAX IN NORTH AMERICA; 9.3 THE ANTHRAX DISTRICTS AFTER 1944; 9.4 MOLECULAR GENOTYPING OF B . ANTHRACIS; 9.5 GENOTYPES WITHIN THE ANTHRAX DISTRICTS IN NORTH AMERICA9.6 PHYLOGENETIC RESOLUTION WITHIN THE WNA LINEAGEThis book is a unique synthesis of the major concepts and methods in bacterial population genetics in infectious disease, a field that is now about 35 yrs old. Emphasis is given to explaining population-level processes that shape genetic variation in bacterial populations and statistical methods of analysis of bacterial genetic data. A ""how to"" of bacterial population genetics, which covers an extremely large range of organisms Expanding area of science due to high-throughput genome sequencing of bacterial pathogens Covers both fundamental approaches to analyzingPathogenic bacteriaBacterial geneticsPopulation geneticsPathogenic bacteria.Bacterial genetics.Population genetics.616.07Robinson D. Ashley1640698Falush Daniel1640699Feil Edward J1640700MiAaPQMiAaPQMiAaPQBOOK9910818466503321Bacterial population genetics in infectious disease3984368UNINA