04854nam 2200673 a 450 991081737460332120240417000351.01-280-20397-897866102039700-309-56427-10-585-03808-2(CKB)111069351109030(EBL)3377126(SSID)ssj0000205210(PQKBManifestationID)11200651(PQKBTitleCode)TC0000205210(PQKBWorkID)10192427(PQKB)11095424(MiAaPQ)EBC3377126(Au-PeEL)EBL3377126(CaPaEBR)ebr10068358(CaONFJC)MIL20397(OCoLC)923268432(EXLCZ)9911106935110903019910325d1991 ua 0engur|n|---|||||txtccrMonitoring human tissues for toxic substances /Committee on National Monitoring of Human Tissues, Board on Environmental Studies and Toxoicology, Commission on Life Sciences1st ed.Washington, D.C. National Academy Press19911 online resource (224 p.)Description based upon print version of record.0-309-04437-5 Includes bibliographical references (p. 167-178).""Monitoring Human Tissues for Toxic Substances""; ""Copyright""; ""Preface""; ""Contents""; ""Executive Summary""; ""THE NATIONAL HUMAN MONITORING PROGRAM""; ""CHARGE TO THE COMMITTEE""; ""RELATIONSHIP OF TISSUE MONITORING TO EPA PROGRAM PRIORITIES""; ""GOALS AND POTENTIAL USES OF A NATIONAL PROGRAM TO MONITOR HUMAN TISSUES""; ""CONCLUSIONS AND RECOMMENDATIONS""; ""Toxicologic Issues""; ""Relevance of Human Tissue Monitoring to Risk Assessment""; ""Choice of Tissues to Monitor""; ""Sampling Methods""; ""Collection, Short-Term Storage, and Archiving of Tissues""""Chemical Assay of Specimens""""Program Design and Management Issues""; ""Administrative and Agency Issues""; ""Funding""; ""Science Review""; ""Other Administrative Issues""; ""Analysis and Reporting of Data""; ""Cooperation and Information Transfer with Other Organizations""; ""Monitoring Human Tissues for Toxic Substances""; ""1 Introduction ""; ""BACKGROUND""; ""CHARGE TO THE COMMITTEE""; ""ENVIRONMENTAL AND PUBLIC HEALTH RATIONALE FOR MONITORING CHEMICALS IN HUMAN TISSUES""; ""RELATIONSHIP OF TISSUE MONITORING TO EPA PROGRAM PRIORITIES""""GOALS AND POTENTIAL USES OF A NATIONAL PROGRAM TO MONITOR HUMAN TISSUES""""2 Review of the National Human Adipose Tissue Survey and Selected Program Alternatives ""; ""DEVELOPMENT OF THE PROGRAM""; ""Program Deficiencies""; ""Toxicologic Issues (see Chapter 3)""; ""Sampling Strategy (See Chapter 4)""; ""Collection, Storage, and Archiving of Tissues (see Chapter 5)""; ""Chemical Assay Issues (see Chapter 6)""; ""Programmatic Issues (see Chapter 7)""; ""EXISTING PROGRAMS AS POSSIBLE ALTERNATIVES TO THE NATIONAL HUMAN ADIPOSE TISSUE SURVEY""""National Center for Health Statistics: National Health and Nutrition Examination Surveys (NHANES)""""Agency for Toxic Substances and Disease Registry: National Exposure and Disease Registries""; ""National Institute of Standards and Technology: Environmental Specimen Banking Program""; ""Environmental Protection Agency: Total Exposure Assessment Methodology Study""; ""Food and Drug Administration: Total-Diet Study""; ""National Oceanographic and Atmospheric Administration: National Status and Trends Mussel Watch Program""; ""Foreign Programs""; ""Conclusions""""SUMMARY AND RECOMMENDATIONS""""3 Toxicologic Issues ""; ""INTRODUCTION""; ""RELATION BETWEEN ENVIRONMENTAL MONITORING AND TISSUE MONITORING""; ""RELEVANCE OF HUMAN TISSUE MONITORING TO RISK ASSESSMENT""; ""Biologic Markers""; ""Markers of Exposure or Dose""; ""Markers of Effect""; ""Markers of Biologically Effective Dose""; ""Markers of Early Biologic Effect""; ""Markers of Susceptibility""; ""Summary""; ""CHOICE OF TISSUES TO MONITOR""; ""Background""; ""Blood""; ""Adipose Tissue""; ""Lean Tissues""; ""Biologic Fluids""; ""Hair""; ""SUMMARY AND RECOMMENDATIONS""; ""4 Sampling Methods """"INTRODUCTION""Biological monitoringUnited StatesBloodAnalysisUnited StatesAdipose tissuesAnalysisUnited StatesHealth risk assessmentBiological monitoringBloodAnalysisAdipose tissuesAnalysisHealth risk assessment.615.9/07MiAaPQMiAaPQMiAaPQBOOK9910817374603321Monitoring human tissues for toxic substances3972178UNINA