03085nam 2200565 a 450 991081672460332120240410171037.01-61470-207-1(CKB)2670000000149002(EBL)3019817(SSID)ssj0000691226(PQKBManifestationID)12225615(PQKBTitleCode)TC0000691226(PQKBWorkID)10629372(PQKB)11478296(MiAaPQ)EBC3019817(Au-PeEL)EBL3019817(CaPaEBR)ebr10671382(OCoLC)777549337(EXLCZ)99267000000014900220090625d2009 uy 0engurcn|||||||||txtccrMannose-binding lectin in the innate immune system[electronic resource] /Iara de Messias-Reason and Angelica B.W. Boldt1st ed.Hauppauge, N.Y. Nova Biomedical Books20091 online resource (99 p.)Description based upon print version of record.1-60692-716-7 Includes bibliographical references and index.Intro -- MANNOSE-BINDING LECTIN INTHE INNATE IMMUNE SYSTEM -- MANNOSE-BINDING LECTIN INTHE INNATE IMMUNE SYSTEM -- CONTENTS -- PREFACE -- INTRODUCTION -- 1. MANNOSE BINDING LECTIN (MBL)CHARACTERISTICS -- 1a. MBL2 Gene and Protein Structure -- 1b. MBL2 Transcription and Translation -- 2. MBL FUNCTIONS -- 2a. Activation of Complement -- 2b. Opsonophagocytosis -- 2c. Modulation of Inflamation -- 2d. Recognition of Altered Self and Apoptosis -- 2e. Other MBL Functions -- 3. MBL2 GENE POLYMORPHISM -- 3a. MBL2 Variants and Allelic Haplotypes -- 3b. Worldwide Distribution of MBL2 Haplotypes -- MBL2 ASSOCIATION WITH DISEASES -- 1. POSITIVE ASSOCIATION OF MBL DEFICIENCYWITH DISEASES -- 1a. Otitis Media and other Pediatric Infections -- 1b. Meningitis -- 1c. Mycoplasma Infection -- 1d. Emergent Viral Infection -- 1e. Fungal Infections -- 1f. Malaria -- 1g. Neutropenia -- 1h. Hepatitis B -- 1i. HIV Infection -- 1j. Cystic Fibrosis -- 1k. Systemic Inflammatory Response Syndrome -- 1l. Cardiovascular Diseases -- 1m. Systemic Lupus Erythematosus -- 1n. Gastrointestinal Diseases -- 2. NEGATIVE ASSOCIATION OF MBL DEFICIENCYWITH DISEASES -- 2a. Leprosy -- 2b. Tuberculosis -- 2c. Leishmaniasis -- 2d. Hepatitis C -- 2e. Rheumatic Heart Disease -- 2f. Rheumatoid Arthritis -- 2g. Ischemia/Reperfusion Injury -- 2h. Other Diseases -- 3. MBL AND HETEROZYGOTE ADVANTAGE -- 4. MBL THERAPY -- CONCLUSION -- REFERENCES -- INDEX.LectinsNatural immunityMannoseLectins.Natural immunity.Mannose.616.079De Messias-Reason Iara1695838Boldt Angelica B. W1695839MiAaPQMiAaPQMiAaPQBOOK9910816724603321Mannose-binding lectin in the innate immune system4075370UNINA