03139nam 2200697Ia 450 991081626870332120200520144314.09786612491269978128249126712824912619781444318579144431857897814443185861444318586(CKB)2550000000006559(EBL)480427(OCoLC)606871882(SSID)ssj0000358524(PQKBManifestationID)11305168(PQKBTitleCode)TC0000358524(PQKBWorkID)10377769(PQKB)10427351(MiAaPQ)EBC480427(Au-PeEL)EBL480427(CaPaEBR)ebr10361197(CaONFJC)MIL249126(Perlego)2756079(EXLCZ)99255000000000655920090826d2010 uy 0engur|n|---|||||txtccrCritical pathways to success in CNS drug development /Neal R. Cutler ... [et al.]2nd ed.Chichester, UK ;Hoboken, NJ Wiley-Blackwell20101 online resource (273 p.)Description based upon print version of record.9781444330649 1444330640 Includes bibliographical references and index.Critical Pathwaysto Success in CNSDrug Development; Contents; Acknowledgments; Foreword; 1 The impending crisis in CNS drug development; 2 Animal models and procedures for CNS disorders; 3 Preclinical antecedents to early human clinical trials; 4 Biomarkers and surrogate markers in drug development; 5 Neuroimaging and cognitive assessments in early drug development; 6 Bridging and CSF studies; 7 A case study from preclinical to early clinical trials; IndexCovering the latest advances in CNS drug development, this book will guide all those involved in pre-clinical to early clinical trials. The authors describe how recent innovations can accelerate the development of novel CNS compounds, improve early detection of efficacy and toxicity signals, and increase the safety of later-stage clinical trials. The current crisis in the drug development industry is critically reviewed, as well as the steps needed to correct the problems, including new government-backed regulations and industry-based innovations designed to accelerate CNS drug development iNeuropsychopharmacologyDrug developmentCritical path analysisCentral nervous systemEffect of drugs onResearchMethodologyNeuropsychopharmacology.Drug development.Critical path analysis.Central nervous systemEffect of drugs onResearchMethodology.615Cutler Neal R930110MiAaPQMiAaPQMiAaPQBOOK9910816268703321Critical pathways to success in CNS drug development4044113UNINA