03180oam 22006372a 450 991081590790332120240516134423.01-118-35432-X1-299-31459-71-118-35433-81-118-35430-31-118-35431-1(CKB)2670000000231132(EBL)875932(OCoLC)805560505(SSID)ssj0000694988(PQKBManifestationID)11416226(PQKBTitleCode)TC0000694988(PQKBWorkID)10686134(PQKB)10639388(DLC) 2012008118(MiAaPQ)EBC875932(PPN)178867330(EXLCZ)99267000000023113220120224d2013 uy 0engur|n|---|||||txtccrBiopharmaceutics modeling and simulations[electronic resource] theory, practice, methods, and applications /Kiyohiko Sugano1st ed.Hoboken, N.J. John Wiley & Sonsc20131 online resource (521 p.)Description based upon print version of record.1-118-02868-6 Includes bibliographical references and index.Introduction -- Theoretical framework I : solubility -- Theoretical framework II : dissolution -- Theoretical framework III : biological membrane permeation -- Theoretical framework IV : gastrointestinal transit models and integration -- Physiology of gastrointestinal tract and other administration sites in humans and animals -- Drug parameters -- Validation of mechanistic models -- Bioequivalence and biopharmaceutical classification system -- Dose and particle size dependency -- Enabling formulations -- Food effect -- Biopharmaceutical modeling for miscellaneous cases -- Intestinal transporters -- Strategy in drug discovery and development -- Epistemology of biopharmaceutical modeling and good simulation practice. A comprehensive introduction to using modeling and simulation programs in drug discovery and development Biopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development process, including drug substance design, formulation design, and toxicological exposure assessment, biopharmaceutical modeling is now seen as the linchpin to a drug's future success. And while there are a number of commercially available software programs for drug modeling, there has not been a single resource guiding pharmaceutical professioBiopharmaceuticsmethodsComputer SimulationDrug CompoundingmethodsModels, TheoreticalBiopharmaceuticsmethods.Computer Simulation.Drug Compoundingmethods.Models, Theoretical.615.19Sugano Kiyohiko1642541DLCDLCDLCBOOK9910815907903321Biopharmaceutics modeling and simulations3987299UNINA