02682nam 2200541 a 450 991081494000332120200520144314.01-60805-142-0(CKB)2670000000099380(EBL)864309(OCoLC)779141452(SSID)ssj0000672883(PQKBManifestationID)11417123(PQKBTitleCode)TC0000672883(PQKBWorkID)10636419(PQKB)11579601(MiAaPQ)EBC864309(Au-PeEL)EBL864309(CaPaEBR)ebr10492620(EXLCZ)99267000000009938020110922d2011 uy 0engurcn|||||||||txtccrIn silico lead discovery /by Maria A. Miteva1st ed.[Saif Zone, Sharjah, United Arab Emirates] Bentham Science Publishers Ltd.[2011]1 online resource (201 p.)Description based upon print version of record.1-60805-313-X Includes bibliographical references and index.01 Title.pdf; 02 Cover Page; 03 eBooks End User License Agreement-Website; 04 Content; 05 Foreword_Grigirov; 06 Preface_Miteva; 07 Contributors_Proposal_forEbook-MariaMiteva; 08 Chapter 1 Lagorce_et al_revised 2; 09 Chapter 2 Sperandio_et al_revised 2; 10 Chapter 3 Guyon_Tuffery_corrected 2; 11 Chapter 4 Todorov_corrected 2; 12 Chapter 5 Alexov_revised 2; 13 Chapter 6 Miteva_revised 2; 14 Chapter 7 Roche-revised 2; 15 Chapter 8 Pajeva_Wiese_revised 2; 16 Chapter 9 Moro_revised 2; 17 Chapter 10 Lee; 18 IndexComputer-aided drug design and in silico screening have contributed to the discovery of several compounds that have either reached the market or entered clinical trials. In silico Lead Discovery is a compilation of the efforts of several experts on bioinformatics and drug design in developing the latest advances of in silico approaches for lead discovery. It contains an overview of structure-based, ligand-based methods and current fragment-based methods as well as examples for successful applications of such methods in discovering new hit/lead molecules for important therapeutic targets. TreatDrug developmentDrug developmentComputer simulationDrug development.Drug developmentComputer simulation.615/.19Miteva Maria A1706251MiAaPQMiAaPQMiAaPQBOOK9910814940003321In silico lead discovery4093530UNINA