03389nam 2200649 a 450 991081435590332120230316171339.01-84755-070-31-60119-027-1(CKB)1000000000238269(EBL)1185420(SSID)ssj0000071754(PQKBManifestationID)11107178(PQKBTitleCode)TC0000071754(PQKBWorkID)10091565(PQKB)10393614(MiAaPQ)EBC1185420(Au-PeEL)EBL1185420(CaPaEBR)ebr10621270(CaONFJC)MIL871773(OCoLC)843641090(PPN)198475810(EXLCZ)99100000000023826920060105h20022002 uy 0engur|n|---|||||txtrdacontentcrdamediacrrdacarrierDrug design cutting edge approaches /editor, Darren R. FlowerCambridge :Royal Society of Chemistry,2002.©20021 online resource (x, 192 pages) illustrationsSpecial publication ;no. 279"Proceedings of the meeting on Cutting Edge Approaches to Drug Design held on 13 March 2001 at the Scientific Societies Lecture Theatre, London, UK"--T.p. verso.0-85404-816-2 Includes bibliographical references and index.CONTENTS; Molecular Informatics: Sharpening Drug Design's Cutting Edge; High-Throughput X-Ray Crystallography for Drug Discovery; Trawling the Genome for G Protein-coupled Receptors: the Importance of Integrating Bioinformatic Approaches; Virtual Screening of Virtual Libraries - an Efficient Strategy for LeadGeneration; Virtual Techniques for Lead Optimisation; The Impact of Physical Organic Chemistry on the Control of Drug-likeProperties; Mutagenesis and Modelling Highlight the Critical Nature of theTM2-loop-TM3 Region of Biogenic Amine GPCRS; Computational Vaccine Design; Subject IndexPharmaceutical research draws on increasingly complex techniques to solve the challenges of drug design. Bringing together a number of the latest informatics techniques, this book looks at modelling and bioinformatic strategies; structural genomics and X-ray crystallography; virtual screening; lead optimisation; ADME profiling and vaccine design. A number of relevant case studies, focussing on techniques that have demonstrated their use, will concentrate on G-protein coupled receptors as potential disease targets.Providing details of state-of-the-art research, Drug Design: Cutting Edge ApproacSpecial publication (Royal Society of Chemistry (Great Britain)) ;279.DrugsDesignCongressesDrugsDesignMathematical modelsCongressesArtificial intelligenceMedical applicationsCongressesDrugsResearchMethodologyCongressesDrugsDesignDrugsDesignMathematical modelsArtificial intelligenceMedical applicationsDrugsResearchMethodology615.19Flower Darren R472707MiAaPQMiAaPQMiAaPQBOOK9910814355903321Drug design3963642UNINA