04687nam 2200601 450 991081433370332120200520144314.00-12-809647-0(CKB)3710000000561530(EBL)4307846(SSID)ssj0001634470(PQKBManifestationID)16386990(PQKBTitleCode)TC0001634470(PQKBWorkID)14950277(PQKB)11694147(Au-PeEL)EBL4307846(CaPaEBR)ebr11153512(CaONFJC)MIL884205(OCoLC)935257604(MiAaPQ)EBC4307846(EXLCZ)99371000000056153020160218h20162016 uy 0engur|n|---|||||txtccrAmphioxus immunity tracing the origins of human immunity /edited by Anlong XuAmsterdam, [Netherlands] :Elsevier,2016.©20161 online resource (355 p.)Description based upon print version of record.0-12-849903-6 Includes bibliographical references and indexes.Cover; Title Page; Copyright Page; Dedication; Contents; List of contributors; About the Author; Foreword; Preface; Chapter 1 - Amphioxus as a Model for Understanding the Evolution of Vertebrates; 1.1 - Brief introduction of amphioxus; 1.2 - Biology of amphioxus; 1.2.1 - Reproduction and embryogenesis of amphioxus; 1.2.2 - Anatomy of amphioxus; 1.3 - The story of amphioxus and early research studies in China; References; Chapter 2 - Basic Knowledge of Immunology; 2.1 - Immune organs; 2.1.1 - Primary lymphoid organs; 2.1.1.1 - Bone marrow; 2.1.1.2 - Thymus; 2.1.2 - Secondary lymphoid organs2.1.2.1 - Lymph nodes2.1.2.2 - Spleen; 2.1.2.3 - Mucosa-associated lymphoid tissue; 2.2 - Immune cells; 2.2.1 - Lymphoid cells; 2.2.1.1 - B cells; 2.2.1.2 - T cells; 2.2.1.3 - NK cells; 2.2.2 - Innate immunity-associated cells; 2.2.2.1 - Neutrophils; 2.2.2.2 - Macrophages; 2.2.2.3 - Dendritic cells; 2.3 - Innate immunity; 2.3.1 - Toll-like receptors involved in the signaling pathway; 2.3.2 - NOD-like receptors and their functions; 2.3.3 - RIG-like receptors; 2.3.4 - C-type lectins; 2.3.5 - The scavenger receptors; 2.3.6 - Inflammation; 2.4 - Adaptive immunity; 2.4.1 - Specificity2.4.2 - Diversity2.4.3 - Immunological memory; 2.4.4 - Self-nonself recognition; 2.5 - Complement system; 2.5.1 - Complement pathways; 2.5.1.1 - Classical pathway; 2.5.1.2 - Lectin pathway; 2.5.1.3 - Alternative pathway; 2.5.2 - Complement in host defense; References; Chapter 3 - Immune Organs and Cells of Amphioxus; 3.1 - Introduction; 3.2 - Organs of the amphioxus immune system; 3.2.1 - Amphioxus gill slits: the first immune defense line; 3.2.2 - Amphioxus intestine: not just a digestive organ but also an immune organ; 3.3 - Cells of the amphioxus immune system; 3.3.1 - Phagocytes3.3.2 - Lymphocyte-like cellsReferences; Chapter 4 - Genomic and Transcriptomic View of Amphioxus Immunity; 4.1 - Introduction; 4.2 - Trace evidence of adaptive immunity; 4.2.1 - TCRs, Igs, VLRs, and the origins of RAG; 4.2.2 - MHC and genes involved in antigen presentation; 4.3 - Extraordinary gene expansion in amphioxus innate immunity; 4.3.1 - The TLR system; 4.3.2 - The NLR system; 4.3.3 - LRRIG proteins; 4.3.4 - Other LRR-containing genes; 4.3.5 - C-type lectins; 4.3.6 - Scavenger receptors; 4.3.7 - RIG-I-like helicases; 4.3.8 - Complement-related receptors; 4.3.9 - The TNF system4.3.10 - Expansion and reshuffling of the death-fold domains4.3.11 - Expansion of TIR adaptors, TRAFs, and initiator caspases; 4.3.12 - Cytokines, kinases, and transcription factors; 4.4 - Regulation of the amphioxus immune system; 4.4.1 - Differential regulatory patterns between expanded gene families; 4.4.2 - The regulation during bacterial infection; 4.4.3 - The regulation of the terminal signaling network; 4.4.4 - Differential expression patterns observed within TNF and IL-1R systems; 4.4.5 - Major pathways in a complex signaling network; 4.4.6 - A functional prototypic complement system4.4.7 - The prototype of the oxidative burst-like systemMarine invertebratesPictorial worksMarine invertebratesPhysiologyMarine invertebratesMarine invertebratesPhysiology.592.177Xu AnlongMiAaPQMiAaPQMiAaPQBOOK9910814333703321Amphioxus immunity4003068UNINA