05051nam 2200577 450 991081316340332120230614191937.01-908230-68-1(CKB)3710000000057343(EBL)1909043(SSID)ssj0001159022(PQKBManifestationID)11647370(PQKBTitleCode)TC0001159022(PQKBWorkID)11113249(PQKB)11577158(MiAaPQ)EBC1909043(MiAaPQ)EBC5897799(Au-PeEL)EBL5897799(OCoLC)878078185(EXLCZ)99371000000005734320191014d2014 uy 0engur|n|---|||||txtccrGenome analysis current procedures and applications /edited by Maria S. PoptsovaNorfolk, England :Caister Academic Press,[2014]©20141 online resource (389 p.)Description based upon print version of record.1-908230-29-0 Includes bibliographical references and index.Contents; Contributors; Preface; 1 Identification of Structural Variation; Introduction; Defining structural variants; Causes of structural variation; Early methods for SV identification; Identification of structural variation from sequencing data; Discussion; Future trends; 2 Methods for RNA Isolation, Characterization and Sequencing (RNA-Seq); A brief history of RNA; Principles of RNA isolation; Methods of RNA sequencing; Using RNA sequencing to define transcriptional landscapes; RNA sequencing to discover RNA modifications; RNA base modifications and epitranscriptomics; Conclusions3 Transcriptome Reconstruction and Quantification from RNA Sequencing DataIntroduction; Transcriptome reconstruction; Transcriptome quantification; Future trends; Conclusions; 4 Identification of Small Interfering RNA from Next-generation Sequencing Data; Introduction; Applying sequencing technologies to siRNAs; Experimental designs; Available tools for analysis of siRNA-seq data; Processing of siRNA-seq data; Locus finding; Association of siRNA loci with genomic features; Differential expression in siRNAs; Phased siRNAs; Post-analysis visualization; Target finding and small RNA networksDiscussion5 Motif Discovery and Motif Finding in ChIP-Seq Data; Introduction; ChIP-Seq data: advantages and challenges for sequence analysis bioinformatics; Cooking recipes for motif analysis of ChIP-Seq data; Conclusion: the present and the future of motif analysis for the ChIP-Seq technology; 6 Mammalian Enhancer Prediction; Introduction; Transcriptional enhancers; Computational prediction of enhancers; Discussion and conclusions; Future trends; 7 DNA Patterns for Nucleosome Positioning; Nucleosome as the basic unit of chromatin; Role of nucleosome positioning in gene regulationDifferent nucleosome sequence patternsEarly history (pre-genomic and genomic era); Post-genomic era and high-throughput data; Positive versus negative, combining and splitting the patterns; Discussion and conclusions; 8 Hypermethylation in Cancer; Introduction: hypermethylation in the context of other epigenetic modifications; Types of DNA methylation; Hypermethylation machineries: the role of DNMTs; Epigenetic factors contribute to tumourigenesis and cancer progression; Biological pathways of frequently methylated genes in cancerThe relevance of high-throughput technologies as accelerating discovery means of epigenetic events in cancerTranslational applications of methylome analyses as a source of cancer biomarkers; Conclusions; Acknowledgements; References; 9 Identification and Analysis of Transposable Elements in Genomic Sequences; Introduction; Classic detection methods for TEs in genome sequences; TEs in the next-generation sequencing data era; What do NGS data bring to TE analyses?; Conclusions; Future trends; 10 The Current State of Metagenomic Analysis; Introduction; Metagenome sequencingMetagenome sequencing protocolsIn recent years, there have been tremendous achievements made in DNA sequencing technologies and corresponding innovations in data analysis and bioinformatics that have revolutionized the field of genome analysis. In this book, an impressive array of experts highlight and review current advances in genome analysis. The book provides an invaluable, up-to-date, and comprehensive overview of the methods currently employed for next-generation sequencing (NGS) data analysis. It also highlights their problems and limitations, and it demonstrates the applications and indicates the developing trends iGene mappingGene mapping.572.8633Poptsova Maria S.MiAaPQMiAaPQMiAaPQBOOK9910813163403321Genome analysis875199UNINA03391nam 22006855 450 991042264250332120251204110041.03-030-58900-510.1007/978-3-030-58900-4(CKB)4100000011469469(MiAaPQ)EBC6356670(DE-He213)978-3-030-58900-4(MiAaPQ)EBC6356616(EXLCZ)99410000001146946920200923d2020 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierCultural Dynamics of Water in Iranian Civilization /by Majid Labbaf Khaneiki1st ed. 2020.Cham :Springer International Publishing :Imprint: Springer,2020.1 online resource (X, 155 p. 32 illus., 10 illus. in color.) 3-030-58899-8 Introduction -- Production and Water Culture -- Hydro-Political Organization -- Hydro-social cohesion -- Drought Pump -- The Water Delusion.This book traces “water” back to the most primitive animistic notions that are still lingering on in the shape of such rituals as qanat marriage or rain-making. Water, in the Iranian philosophy, is used in an attempt to find an explanation for the genesis of the universe, as described in Zoroastrian Akhshij philosophy, according to which water is one of the four fundamental elements of the creation. The concept of time began to germinate in the Iranian mind, when they had to count the passage of time in order to divide their scarce water resources. Water became so omnipresent in Iranian culture that it reached even the most mysterious seclusion of the Sufi monks. In Iran’s local communities, water culture is a thread that runs through different types of production systems. This book goes beyond indigenous water knowledge and traditional irrigation techniques, and conceptualizes water as a pivotal element of Iran’s social identity, cultural dynamics and belief systems, whereit examines the role of intermittent droughts in engendering and diffusing intangible cultural elements across the Iranian plateau. This book delves into Iran’s political organizations most of which were ensnared in a water-dependent lifecycle constituting a historical pattern described in this book as “hydraulic collapse” .EthnologyWaterHydrologyEthnologyMiddle EastCultureAnthropologyHuman geographySociocultural AnthropologyWaterMiddle Eastern CultureAnthropologyHuman GeographyEthnology.Water.Hydrology.EthnologyCulture.Anthropology.Human geography.Sociocultural Anthropology.Water.Middle Eastern Culture.Anthropology.Human Geography.553.70955Labbāf Khānīkī Majīd1059604MiAaPQMiAaPQMiAaPQBOOK9910422642503321Cultural dynamics of water in Iranian civilization2507338UNINA