05428nam 2200697Ia 450 991081249500332120240418094858.01-281-84122-697866118412250-470-98573-90-470-98572-0(CKB)1000000000550229(EBL)366789(OCoLC)437234401(SSID)ssj0000217141(PQKBManifestationID)11197958(PQKBTitleCode)TC0000217141(PQKBWorkID)10198262(PQKB)10479276(MiAaPQ)EBC366789(Au-PeEL)EBL366789(CaPaEBR)ebr10257619(CaONFJC)MIL184122(EXLCZ)99100000000055022920070810d2008 uy 0engurcn|||||||||txtccrOvercoming steroid insensitivity in respiratory disease[electronic resource] /edited by Ian M. Adcock and Kian Fan Chung1st ed.Chichester, England ;Hoboken, NJ J. Wileyc20081 online resource (310 p.)Description based upon print version of record.0-470-05808-0 Includes bibliographical references and index.Overcoming Steroid Insensitivity in Respiratory Disease; Contents; List of Contributors; Preface; 1 Molecular Mechanisms of Glucocorticoid Receptor Action; 1.1 Introduction; 1.2 Glucocorticoid Receptor; 1.3 Gene Induction by GR; 1.4 GR Transactivation and Histone Acetylation; 1.5 Post-translational Modifications of GR; 1.6 Repression of NF-κB-induced Inflammatory GeneExpression by GR-NF-κB; 1.7 GR-NF-κB Cross-talk; 1.8 Role of HDAC2 in Glucocorticoid Function; 1.9 Overexpression of HDAC2 Restores Glucocorticoid Sensitivity in Alveolar Macrophages1.10 Acetylation of hsp90 and Regulation of GR Function 1.11 Other Mechanisms of GR Action; 1.12 Conclusions; 2 Side Effects of Topical and Oral Glucocorticoids; 2.1 Introduction; 2.2 Glucocorticoid-induced Side Effects; 2.3 Summary; 3 Glucocorticoid Receptor Subtypes and Steroid Sensitivity; 3.1 Introduction; 3.2 Overview of Classic GR Function; 3.3 GR Subtypes Arising from Alternative Splicing; 3.4 GR Subtypes arising from Alternative Translation Initiation; 3.5 Conclusions; 4 Dissociated Glucocorticoids; 4.1 Introduction4.2 Asthma and Chronic Obstructive Pulmonary Disease are Chronic Inflammatory Diseases of the Airways 4.3 Regulation of Inflammatory Gene Expression; 4.4 Effects on Inflammation; 4.5 Mechanisms of Glucocorticoid Action; 4.6 Dissociated Glucocorticoids; 4.7 GR Cross-talk with Other Nuclear Receptors and Coactivators; 4.8 Overcoming Steroid Insensitivity; 4.9 Glucorticoid-sparing Approaches to Anti-inflammatory Therapy; 4.10 Conclusion; 5 Generalized Glucocorticoid Insensitivity: Clinical Phenotype and Molecular Mechanisms; 5.1 Introduction; 5.2 Molecular Mechanisms of Glucocorticoid Resistance5.3 Conclusions 6 Corticosteroid Responsiveness in Asthma: Clinical Aspects; 6.1 Introduction; 6.2 Effects of Corticosteroids in Asthma; 6.3 Definition of Corticosteroid Insensitivity; 6.4 Oral CS Responsiveness in Asthma; 6.5 ICS Responsiveness in Asthma; 6.6 CS Responsiveness in Severe Asthma; 6.7 Surrogates for CS Responsiveness in Asthma; 6.8 Pharmacokinetics of Systemic CS in Severe Asthma; 6.9 CS Responsiveness in Cigarette Smokers and Chronic Obstructive Pulmonary Disease; 6.10 Other Diseases of CS Insensitivity; 6.11 Conclusions7 Glucocorticoid-insensitive Asthma: Molecular Mechanisms 7.1 Introduction; 7.2 GR Abnormalities; 7.3 GR Nuclear Translocation; 7.4 Cross-talk with Transcription Factors; 7.5 NF-κB, GR, Histones and Chromatin Remodelling; 7.6 Epigenetics and Asthma; 7.7 Conclusions; 8 Cigarette Smoke, Oxidative Stress and Corticosteroid Responsiveness; 8.1 Oxidative Stress; 8.2 Cigarette Smoke/Oxidative Stress-InducedNF-κB-mediated Pro-inflammatory Gene Expression; 8.3 Histone Acetylation and Deacetylation; 8.4 Corticosteroids; 8.5 Histone Deacetylases; 8.6 Reversing Glucocorticoids / Corticosteroid Resistance8.7 ConclusionWritten by well-known experts in field, this is the first book dedicated to dealing with the single most challenging management issue in long-term steroid therapy. Overcoming Steroid Insensitivity in Respiratory Disease reviews important new advances in therapeutics and provides the clinician with the most up to date information on one of the most significant therapeutic challenges to effective management of these diseases. This unique book is an invaluable resource for all postgraduate students and specialist physicians in pulmonology allergy and asthma. It is also of interestRespiratory organsDiseasesChemotherapySteroid drugsDrug resistanceRespiratory organsDiseasesChemotherapy.Steroid drugs.Drug resistance.616.2616.200461Adcock Ian(Ian M.)1643689Chung K. Fan1951-879011MiAaPQMiAaPQMiAaPQBOOK9910812495003321Overcoming steroid insensitivity in respiratory disease3989093UNINA