02994nam 2200733 a 450 991081204800332120240514064652.0978661342514097812834251481283425149978111818332811181833209781118183335111818333997811181833041118183304(CKB)2560000000079115(EBL)817515(OCoLC)772844539(SSID)ssj0000589374(PQKBManifestationID)11941216(PQKBTitleCode)TC0000589374(PQKBWorkID)10657269(PQKB)11080739(MiAaPQ)EBC817515(Au-PeEL)EBL817515(CaPaEBR)ebr10575441(CaONFJC)MIL342514(OCoLC)775437755(Perlego)1003406(EXLCZ)99256000000007911520110809d2012 uy 0engur|n|---|||||txtccrClinical trial design Bayesian and frequentist adaptive methods /Guosheng Yin1st ed.Hoboken, N.J. John Wiley & Sonsc20121 online resource (366 p.)Wiley series in probability and statisticsDescription based upon print version of record.9780470581711 0470581719 Includes bibliographical references and indexes.Fundamentals of clinical trials -- Frequentist versus Bayesian statistics -- Phase I trial design -- Phase II trial design -- Phase III trial design -- Adaptive randomization -- Late onset toxicity -- Drug combination trials -- Targeted therapy design.A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to aWiley series in probability and statistics.Clinical trialsStatistical methodsBayesian statistical decision theoryMathematical statisticsClinical trialsStatistical methods.Bayesian statistical decision theory.Mathematical statistics.610.72/4Yin Guosheng1706988MiAaPQMiAaPQMiAaPQBOOK9910812048003321Clinical trial design4094856UNINA