04459nam 2200697Ia 450 991081140970332120200520144314.00-309-17319-11-280-18599-697866101859930-309-59698-X0-585-06800-3(CKB)110986584752654(OCoLC)70772784(CaPaEBR)ebrary10056956(SSID)ssj0000106767(PQKBManifestationID)11128707(PQKBTitleCode)TC0000106767(PQKBWorkID)10110645(PQKB)10667702(MiAaPQ)EBC3376680(Au-PeEL)EBL3376680(CaPaEBR)ebr10056956(CaONFJC)MIL18599(OCoLC)923265549(EXLCZ)9911098658475265419990524d1999 uy 0engurcn|||||||||txtrdacontentcrdamediacrrdacarrierAssessment of future scientific needs for live variola virus /Committee on the Assessment of Future Scientific Needs for Live Variola Virus, Board on Global Health, Institute of Medicine1st ed.Washington, D.C. National Academy Press19991 online resource (126 pages) illustrationsThe compass seriesBibliographic Level Mode of Issuance: Monograph0-309-06441-4 Includes bibliographical references (p. 87-91).Assessment of Future Scientific Needs for Live Variola Virus -- Copyright -- Preface -- Acknowledgments -- REVIEWERS -- Contents -- Executive Summary -- SCOPE -- SCIENTIFIC NEEDS FOR LIVE AND REPLICATION-DEFECTIVE VARIOLA VIRUS -- OVERALL CONCLUSIONS -- Part I Introduction -- 1 Introduction -- BACKGROUND -- CONTEMPORARY CONTEXT -- SCOPE -- SCIENTIFIC NEEDS FOR VARIOLA VIRUS -- ORGANIZATION OF THIS REPORT -- Part II Smallpox and Its Control -- 2 Variola Virus and Other Orthopoxviruses -- GENERAL ATTRIBUTES OF ORTHOPOXVIRUSES -- POXVIRUS REPLICATION -- PROPERTIES OF SPECIFIC ORTHOPOXVIRUSES -- 3 Clinical Features of Smallpox -- ENTRY AND INFECTION -- DISSEMINATION -- THE RASH -- LESIONS OF THE MUCOUS MEMBRANES -- EFFECTS ON OTHER ORGANS -- IMMUNE RESPONSE -- IMMUNITY AGAINST SMALLPOX -- 4 Epidemiology -- CHARACTERISTICS OF HISTORICAL OUTBREAKS -- LIKELY CHARACTERISTICS OF FUTURE SMALLPOX OUTBREAKS -- CONTROL STRATEGIES -- 5 Variola Virus Stocks Following Eradication of Smallpox -- ESTABLISHMENT OF INTERNATIONAL REPOSITORIES -- DECISION BY THE WORLD HEALTH ASSEMBLY TO DESTROY VARIOLA VIRUS STOCKS -- U.S. RESEARCH ON SMALLPOX -- RESEARCH AT CDC AND USAMRIID -- Part III Scientific Needs for Variola Virus -- 6 Development of Antiviral Agents -- IN VITRO ASSAYS -- ANIMAL MODELS -- 7 Development of Vaccines -- CURRENT STATUS OF VACCINIA VACCINE PREPARATIONS -- EVALUATION OF VACCINIA VACCINE DERIVED FROM TISSUE CULTURE -- EVALUATION OF NOVEL VACCINES -- 8 Detection and Diagnosis -- ENVIRONMENTAL DETECTION -- DIAGNOSIS OF INFECTION -- ALTERNATIVES TO LIVE VIRUS -- 9 Bioinformatics -- VARIABILITY OF VARIOLA VIRUS -- POTENTIAL DEVELOPMENTS -- 10 Understanding of the Biology of Variola Virus -- VIRUS-CELL INTERACTIONS -- VIRUS-HOST INTERACTIONS -- 11 Research on the Expressed Protein Products of Variola -- SYNTHESIS OF VARIOLA PROTEINS.POTENTIAL UTILITY OF VARIOLA PROTEINS -- Part IV Findings -- 12 Summary and Conclusions -- THE BROADER CONTEXT -- SCIENTIFIC NEEDS FOR LIVE VARIOLA VIRUS -- OVERALL CONCLUSIONS -- References -- Appendix A Glossary -- Appendix B Acronyms -- Appendix C Committee and Staff Biographies -- Staff.Compass series (Washington, D.C.)Live variola virusSmallpoxResearchSmallpoxPreventionSmallpox vaccineVirologyCultures and culture mediaSmallpoxResearch.SmallpoxPrevention.Smallpox vaccine.VirologyCultures and culture media.616.9/12Institute of Medicine (U.S.).Committee on the Assessment of Future Scientific Needs for Live Variola Virus.MiAaPQMiAaPQMiAaPQBOOK9910811409703321Assessment of future scientific needs for live variola virus4037708UNINA