03215nam 2200421z- 450 991022734630332120231214133322.0(CKB)4100000000883870(oapen)https://directory.doabooks.org/handle/20.500.12854/53830(EXLCZ)99410000000088387020202102d2017 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMolecular Diagnostics in the Detection of Neurodegenerative DisordersFrontiers Media SA20171 electronic resource (90 p.)Frontiers Research Topics2-88945-194-1 Neurodegeneration is characterized by the progressive loss of neural tissue that result in various neurodegeneration-initiated cerebral failures and complex diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease. All these medical conditions are accompanied by the disruption of blood-brain barrier (BBB). The BBB is an interface, separating the brain from the circulatory system and protecting the central nervous system from potentially harmful chemicals while regulating transport of essential molecules and maintaining a stable environment. Owing to the inability of the neurons to regenerate on their own after neurodegeneration or severe damage to the neural tissue, neurodegenerative disorders do not have natural cures on their own. Neuroregeneration is a viable way to curb neurodegeneration. One of the current approaches is stem cell-based therapy that has been shown to be potentially helpful for the application of neuronal cell replacement for neuroregeneration. It is vital that the neurodegenerative disorder being detected at an early stage as it can provide a chance for treatment that may be helpful to prevent further progression of the fatal disease. Thus, research has focused on developing effective non-invasive diagnostic methods for early detection of these disorders. Molecular diagnostics can provide a powerful method to detect and diagnose various neurological disorders. Such diagnosis can enhance early detection, provide subsequent medical counsel based on medical pathway, as well as to gain better insight of neurogenesis and hopefully eventual cure of the neurodegenerative diseases. With research reports, reviews, mini-reviews and commentary, this research topic covers a wide range of areas in neurodegeneration research, including diagnosis and prognosis; regulating central nervous system; biomarkers and brain injury induced neurobehavioral outcomes among other timely reports on neurodegeneration.Stem CellsNeurodegenerative DiseasesNeuroprotectionNeuronsbiomarkersMicroRNAsneurodegenerationdiagnosisExosomesHemorrhageWilliam C. Choauth1287598Megha AgrawalauthBOOK9910227346303321Molecular Diagnostics in the Detection of Neurodegenerative Disorders3020196UNINA02863nam 2200553Ia 450 991078853540332120200520144314.01-283-61572-X97866139281770-7618-4715-4(CKB)3360000000435226(EBL)1037721(OCoLC)817814171(SSID)ssj0000720438(PQKBManifestationID)12313356(PQKBTitleCode)TC0000720438(PQKBWorkID)10679750(PQKB)10172492(Au-PeEL)EBL1037721(CaPaEBR)ebr10606972(CaONFJC)MIL392817(MiAaPQ)EBC1037721(EXLCZ)99336000000043522620090515d2009 uy 0engur|n|---|||||txtccrThe Dominican Republic and the beginning of a revolutionary cycle in the Spanish Caribbean, 1861-1898[electronic resource] /Luis Alvarez LopezLanham, MD University Press of America20091 online resource (119 p.)Description based upon print version of record.0-7618-4714-6 Includes bibliographical references (p. [91]-96) and index.Cover; Title Page; Copyright Page; Dedication Page; Table of Contents; Lists of Graphs and Tables; Foreword; Preface; Acknowledgments; Chapter 1: Seventeen Fundamental Conclusions about the Annexation to Spain and the Restoration War of The Dominican Republic: 1861-1865; Chapter 2: Kidnapping the Rebels' Goods: State and Society Under the Last Spanish Domination of Quisqueya (1863-1865); Chapter 3: Santo Domingo, Puerto Rico and Cuba: Between National Independence and Spanish Colonialism 1844-1859Chapter 4: Ramon Emeterio Betances and the Revolutionary Cycle in the Spanish Caribbean (From the Restoration War to the Cuban Spanish American Philippines War 1864-1898)Chapter 5: The Spanish Soldiers in the Last Campaign of Santo Domingo: Diseases, Injuries, Disables and Deaths 1861-1865; Research, Sources and Bibliography; IndexIn this book, Álvarez-López details the history of revolution in the Dominican Republic, an infant independent nation struggling to preserve its political independence from Haiti and from the expansionist policies of northern European countries and the United States.Dominican RepublicHistory1844-1930Dominican RepublicAnnexation to Spain972.93Alvarez López Luis1493972MiAaPQMiAaPQMiAaPQBOOK9910788535403321The Dominican Republic and the beginning of a revolutionary cycle in the Spanish Caribbean, 1861-18983717257UNINA