05342nam 2200673Ia 450 991081119960332120230725053820.01-283-33323-697866133332301-119-97270-11-119-99893-X1-119-99846-8(CKB)2550000000063588(EBL)697586(OCoLC)773799268(SSID)ssj0000539474(PQKBManifestationID)11357046(PQKBTitleCode)TC0000539474(PQKBWorkID)10568342(PQKB)11406157(OCoLC)768230372(MiAaPQ)EBC697586(EXLCZ)99255000000006358820110518d2011 uy 0engur|n|---|||||txtccrNeuroimaging in addiction[electronic resource] /Bryon Adinoff and Elliot SteinChichester, West Sussex John Wiley & Sons20111 online resource (373 p.)Description based upon print version of record.0-470-66014-7 Includes bibliographical references and index.Neuroimagingin Addiction; Contents; Foreword; List of Contributors; 1 Introduction; 2 An Integrated Framework for Human Neuroimaging Studies of Addiction from a Preclinical Perspective; 2.1 Introduction; 2.2 A Conceptual Framework for Understanding Drug Addiction Based on Preclinical Observations; 2.3 Neuropharmacological Considerations; 2.4 Neuropathology of Chronic Drug Abuse; 2.5 Impulsivity: An Endophenotype for Drug Addiction; 2.6 Compulsivity: Craving versus Drug-Seeking; 2.7 Summary; References3 Structural and Functional Neuroimaging Methods: Applications to Substance Abuse and Addiction3.1 Introduction; 3.2 MRI Based Imaging Tools and their Application to Drug Abuse Research; 3.3 Molecular Imaging with PET and SPECT; 3.4 Summary and Peek into the Future; References; 4 Functional Neuroimaging of the Acute Effects of Drugs of Abuse; 4.1 Introduction; 4.2 Fundamental Neuronal Systems Related to Abuse Liability in Humans; 4.3 Psychostimulants; 4.4 Alcohol; 4.5 Cannabis and the Cannabinoids; 4.6 Opioids; 4.7 Conclusions and Future Directions; References; 5 Reward Processing5.1 Introduction5.2 Neurotransmitter Systems Implicated in Reward Processing; 5.3 Neurotransmitter Systems Involved in Drug-Related Reward Processing; 5.4 Alterations in the Mesostriatal System in Addiction; 5.5 Summary and Outlook; 5.6 Acknowledgments; References; 6 A Neuroimaging Approach to the Study of Craving; 6.1 A Neuroimaging Approach to the Study of Craving; 6.2 Neural Response During Cue-Elicited Craving; 6.3 Associations between Neural and Subjective Response During Cue-Elicited Craving; 6.4 Modulators of Neural Response During Cue-Elicited Craving6.5 Effects of Intervention on the Neural Response During Cue-Elicited Craving6.6 Summary and Integration of Findings; 6.7 Conclusions; References; 7 Impulsivity and Addiction; 7.1 Introduction; 7.2 Impulsivity as Reward versus Control; 7.3 The Neurobiology of Impulsivity; 7.4 Impulsivity and Risk for Developing a Drug Use Disorder; 7.5 Impulsivity in Current Users; 7.6 Impulsivity, Abstinence, and Relapse; 7.7 Conclusion; References; 8 Cognitive Disruptions in Drug Addiction: a Focus on the Prefrontal Cortex; 8.1 Introduction; 8.2 Attention; 8.3 Working Memory; 8.4 Decision-Making8.5 Pre-Morbid Vulnerabilities8.6 Other Brain Regions; 8.7 Limitations Across All Studies; 8.8 Treatment Implications; 8.9 General Summary and Conclusions; 8.10 Acknowledgments; References; 9 Neural Mechanisms of Stress and Addiction; 9.1 Stress and Addiction; 9.2 Neural Circuits of Stress Regulation; 9.3 Dysfunction in the Neural Circuits Underlying Stress and Addiction; 9.4 Interplay of Gene, Stress, and Drug Intake; 9.5 Acknowledgments; References; 10 Anatomical and Neurochemical Evidence of Neurotoxic Changes in Psychostimulant Abuse and Dependence; 10.1 Introduction10.2 Characteristics of PsychostimulantsNeuroimaging in Addiction presents an up-to-date, comprehensive review of the functional and structural imaging human studies that have greatly advanced our understanding of this complex disorder. Approaching addiction from a conceptual rather than a substance-specific perspective, this book integrates broad neuropsychological constructs that consider addiction as a neuroplastic process with genetic, developmental, and substance-induced contributions. The internationally recognized contributors to this volume are leaders in clinical imaging with expertise that spans the addiction specBrainEffect of drugs onBrainRadiographyCompulsive behaviorMagnetic resonance imagingBrainEffect of drugs on.BrainRadiography.Compulsive behaviorMagnetic resonance imaging.616.8616.8047572Adinoff Bryon1670494Stein Elliot1670495MiAaPQMiAaPQMiAaPQBOOK9910811199603321Neuroimaging in addiction4032387UNINA