04274nam 22006972 450 991081098350332120221206231500.01-107-13046-81-280-41821-497866104182131-139-16476-71-139-14710-20-511-18056-X0-511-05706-70-511-30755-10-511-07185-X(CKB)1000000000014478(EBL)217666(OCoLC)437068906(SSID)ssj0000161749(PQKBManifestationID)11159364(PQKBTitleCode)TC0000161749(PQKBWorkID)10219333(PQKB)11208335(UkCbUP)CR9781139164764(MiAaPQ)EBC217666(Au-PeEL)EBL217666(CaPaEBR)ebr10069866(CaONFJC)MIL41821(PPN)261358847(EXLCZ)99100000000001447820111007d2003|||| uy| 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierGenomic Perl from bioinformatics basics to working code /Rex A. Dwyer[electronic resource]Cambridge :Cambridge University Press,2003.1 online resource (xvii, 334 pages) digital, PDF file(s)Title from publisher's bibliographic system (viewed on 05 Oct 2015).0-511-06339-3 0-521-80177-X Includes bibliographical references (p. 318-323) and index.Cover; Half-title; Title; Copyright; Dedication; Contents; Preface; Acknowledgments; CHAPTER ONE The Central Dogma; CHAPTER TWO RNA Secondary Structure; CHAPTER THREE Comparing DNA Sequences; CHAPTER FOUR Predicting Species: Statistical Models; CHAPTER FIVE Substitution Matrices for Amino Acids; CHAPTER SIX Sequence Databases; CHAPTER SEVEN Local Alignment and the BLAST Heuristic; CHAPTER EIGHT Statistics of BLAST Database Searches; CHAPTER NINE Multiple Sequence Alignment I; CHAPTER TEN Multiple Sequence Alignment II; CHAPTER ELEVEN Phylogeny ReconstructionCHAPTER TWELVE Protein Motifs and PROSITECHAPTER THIRTEEN Fragment Assembly; CHAPTER FOURTEEN Coding Sequence Prediction with Dicodons; CHAPTER FIFTEEN Satellite Identification; CHAPTER SIXTEEN Restriction Mapping; CHAPTER SEVENTEEN Rearranging Genomes: Gates and Hurdles; APPENDIX A Drawing RNA Cloverleaves; APPENDIX B Space-Saving Strategies for Alignment; APPENDIX C A Data Structure for Disjoint Sets; APPENDIX D Suggestions for Further Reading; Bibliography; IndexThis introduction to computational molecular biology will help programmers and biologists learn the skills needed to start work in this important, expanding field. The author explains many of the basic computational problems and gives concise, working programs to solve them in the Perl programming language. With minimal prerequisites, the author explains the biological background for each problem, develops a model for the solution, then introduces the Perl concepts needed to implement the solution. The book covers pairwise and multiple sequence alignment, fast database searches for homologous sequences, protein motif identification, genome rearrangement, physical mapping, phylogeny reconstruction, satellite identification, sequence assembly, gene finding, and RNA secondary structure. The concrete examples and step-by-step approach make it easy to grasp the computational and statistical methods, including dynamic programming, branch-and-bound optimization, greedy methods, maximum likelihood methods, substitution matrices, BLAST searching, and Karlin-Altschul statistics. Perl code is provided on the accompanying CD.Perl (Computer program language)Molecular biologyData processingBioinformaticsPerl (Computer program language)Molecular biologyData processing.Bioinformatics.572.80285Dwyer Rex A.632535UkCbUPUkCbUPBOOK9910810983503321Genomic perl1201689UNINA