03906nam 2200601Ia 450 991080949880332120200520144314.01-283-28323-997866132832381-4443-4634-21-4443-4631-8(CKB)2550000000054394(EBL)819327(OCoLC)758981647(SSID)ssj0000607896(PQKBManifestationID)11407859(PQKBTitleCode)TC0000607896(PQKBWorkID)10591206(PQKB)10532292(MiAaPQ)EBC819327(EXLCZ)99255000000005439420110418d2012 uy 0engur|n|---|||||txtccrAdvanced therapy for hepatitis C /edited by Geoffrey W. McCaughan, John G. McHutchison, Jean-Michel Pawlotsky1st ed.Chichester, West Sussex Wiley-Blackwell20121 online resource (233 p.)Description based upon print version of record.1-4051-8745-X Includes bibliographical references and index.Advanced Therapy for Hepatitis C; Contents; Contributors; Preface; Section I Foundations for Understanding Antiviral Therapies in HCV; 1 HCV Replication; 2 Hepatitis C Virus Genotypes; 3 Immune Responses to HCV: Implications for Therapy; 4 Mechanisms of Action of Antiviral Drugs: The Interferons; 5 Pharmacology and Mechanisms of Action of Antiviral Drugs: Ribavirin Analogs; 6 Pharmacology and Mechanisms of Action of Antiviral Drugs: Polymerase Inhibitors; 7 Pharmacology and Mechanisms of Action of Antiviral Drugs: Protease Inhibitors; 8 Measuring Antiviral ResponsesSection II Efficacy and Clinical Use of Antiviral Therapies9 Genotype 1: Standard Treatment; 10 Individually Tailored Treatment Strategies in Treatment-naïve Chronic Hepatitis C Genotype 1 Patients; 11 Genotype 1 Relapsers and Non-responders; 12 Standard Therapy for Genotypes 2/3; 13 Altered Dosage or Durations of Current Antiviral Therapy for HCV Genotypes 2 and 3; 14 Genotypes 2 and 3 Relapse and Non-response; 15 Hepatitis C Genotype 4 Therapy: Progress and Challenges; 16 Antivirals in Acute Hepatitis C; 17 Antivirals in Cirrhosis and Portal Hypertension18 Treatment of Recurrent Hepatitis C Following Liver Transplantation19 Antiviral Treatment in Chronic Hepatitis C Virus Infection with Extrahepatic Manifestations; 20 Cytopenias: How they Limit Therapy and Potential Correction; 21 The Problem of Insulin Resistance and its Effect on Therapy; 22 HIV and Hepatitis C Co-infection; 23 HCV and Racial Differences; 24 HCV and the Pediatric Population; 25 New Horizons: IL28, Direct-acting Antiviral Therapy for HCV; IndexHepatologists, both researchers and front-line clinicians, now have a comprehensive guide to the treatment of patients with the HCV virus. This book focuses mainly on the efficacy and clinical use of antiviral therapies, including the use of antivirals post liver transplantation and in the presence of the HIV virus. It also explores the foundations for understanding antiviral therapies in HCV, such as the complex pharmacology and mechanisms of antiviral drugs. A 'late-breaking information' chapter contains the most recent trial results on the latest antiviral drugs.Hepatitis CTreatmentAntiviral agentsHepatitis CTreatment.Antiviral agents.616.3/62306McCaughan Geoffrey W1670559McHutchison J. G1763230Pawlotsky Jean-Michel1670561MiAaPQMiAaPQMiAaPQBOOK9910809498803321Advanced therapy for hepatitis C4203559UNINA