04040nam 2200577 450 991078744720332120230120002246.00-12-801959-X(CKB)3710000000337361(EBL)1921148(SSID)ssj0001432653(PQKBManifestationID)11759441(PQKBTitleCode)TC0001432653(PQKBWorkID)11405722(PQKB)11182475(MiAaPQ)EBC1921148(Au-PeEL)EBL1921148(CaPaEBR)ebr11006351(CaONFJC)MIL695234(OCoLC)900464416(EXLCZ)99371000000033736120150127h20152015 uy 0engur|n|---|||||txtccrChemical modulators of protein misfolding and neurodegenerative disease /Pierfausto SeneciLondon, England :Academic Press,2015.©20151 online resource (260 p.)Description based upon print version of record.1-322-63952-3 0-12-801944-1 Includes bibliographical references at the end of each chapters and index.Cover; Title Page; Copyright Page; Dedication; Contents; Abbreviations; Chapter 1 - Chemical Modulators of Protein Misfolding, Neurodegeneration and Tau; 1.1 - Tau-targeted compounds; 1.1.1 - Tau Kinase Inhibitors; 1.1.2 - Tau O-GlcNAcylation Enhancers; 1.1.3 - Microtubule (MT)-binding Compounds; 1.2 - Ab-targeted compounds; 1.2.1 - γ-Secretase Inhibitors (GSIs) and Modulators (GSMs); 1.2.2 - Multi-targeted Neuroprotective and Proneurogenic Compounds; References; Chapter 2 - Targeting the Protein Quality Control (PQC) Machinery; 2.1 - Molecular chaperones, pqc, and neurodegeneration2.2 - Hsp272.3 - Hsp70; 2.3.1 - Hsp70 Inhibitors; 2.3.2 - Hsp70-BAG-1 Inhibitors; 2.4 - Hsp90; 2.4.1 - Hsp90 Inhibitors; 2.4.2 - Hsp90-Co-chaperone Complexes: Direct Inhibition; 2.4.3 - Hsp90-Co-chaperone Complexes: Indirect Inhibition; 2.5 - Recap; References; Chapter 3 - Targeting Proteasomal Degradation of Soluble, Misfolded Proteins; 3.1 - UPS-mediated degradation of misfolded proteins; 3.2 - CHIP; 3.3 - USP14; 3.4 - Recap; References; Chapter 4 - Targeting Unselective Autophagy of Cellular Aggregates; 4.1 - Macroautophagy mediated degradation of protein aggregates; 4.2 - mTORC14.3 - Small molecule enhancers of rapamycin (sMERs)4.4 - Recap; References; Chapter 5 - Targeting Selective Autophagy of Insoluble Protein Aggregates; 5.1 - Aggrephagy-mediated degradation of protein aggregates; 5.2 - p62; 5.3 - HDAC6; 5.4 - Recap; References; Chapter 6 - Targeting Assembly and Disassembly of Protein Aggregates; 6.1 - Disordered protein aggregates and ordered amyloid fibrils; 6.2 - Interfering with (neuro)toxic tau species in the aggregation process; 6.3 - Hsp110-driven disaggregation; 6.4 - Recap; References; Index This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer's and other tauopathies. Properties and development status of these moleculaNervous systemDegenerationNervous systemDegeneration.616.8047Seneci Pierfausto542916Seneci Pierfausto1960-542916MiAaPQMiAaPQMiAaPQBOOK9910787447203321Chemical modulators of protein misfolding and neurodegenerative disease3799949UNINA02868nam 2200481 450 991080850370332120230809235226.093-5280-384-1(CKB)4340000000261200(MiAaPQ)EBC5323996(Au-PeEL)EBL5323996(CaPaEBR)ebr11526570(OCoLC)1029490818(EXLCZ)99434000000026120020200124d2017 uy 0hinurcnu||||||||txtrdacontentcrdamediacrrdacarrierBhartiya Media Vyavsay /Vanitā Kohalī-Khāṇḍekara ; translator, Sachin RathoreLos Angeles ;London ;New Delhi, India :Sage Bhasha,2017.1 online resource (xxxviii, 418 pages)On business policy of Indian mass media.93-5150-685-1 Includes bibliographical references and index.Preface Special Credits The Future of Indian Media Print Television Film Music Radio Ooh Events References and Select Bibliography Index.The Indian Media Business, Fourth Edition gives you detailed analysis, perspective and information on eight segments of the media business in India-print, TV, film, radio, music, digital, outdoor, and events. It presents the business history, current dynamics, regulation, economics, technology, valuations, case studies, trends (Indian and global) and a clear sense of how the business operates. This book is a must-read for media professionals, students and for those planning to invest in the Indian media and entertainment business. The outstanding feature of the fourth edition is a new chapter on digital media-arguably, the first ever look at digital media from a comprehensive business perspective. This looks at everything from history to business dynamics and the major issues digital media faces in India. This edition tackles regulation with more detail than any of the previous ones. There is one large case study on the quality of regulation in India and several caselets such as the ones on copyright law, defamation law and how it works for social media. This edition also contains more caselets than the previous editions. There are caselets on the changes in readership methodology, on the trouble with news broadcasting and on the rising power of Hindi newspapers and the impact of digital on both print and TV among others.Mass mediaIndiaMass mediaIndiaMass mediaMass media.302.230954Kohli Vanita1472919Sachin RathoreMiAaPQMiAaPQMiAaPQBOOK9910808503703321Bhartiya Media Vyavsay3975707UNINA00837nam0 22002411i 450 UON0019637520231205103235.67520030730d1974 |0itac50 baengGB|||| |||||Media sociologya readeredited by Jeremy Tunstall LondonConstable1974IX, 574 p.25 cm.GBLondonUONL003044TunstallJeremyUONV116651ConstableUONV248877650ITSOL20250307RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00196375SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI VI c 2.70 0729 SI LO 1655 5 0729 BuonoMedia sociology1291153UNIOR