03922nam 2200769Ia 450 991080847510332120200520144314.01-282-25001-9978661225001992-4-068367-4(CKB)1000000000787806(EBL)456315(OCoLC)572218688(SSID)ssj0000095629(PQKBManifestationID)11124411(PQKBTitleCode)TC0000095629(PQKBWorkID)10074592(PQKB)10336082(MiAaPQ)EBC456315(Au-PeEL)EBL456315(CaPaEBR)ebr10318254(CaONFJC)MIL225001(OCoLC)935270655(EXLCZ)99100000000078780620090122d2008 uy 0engurcn|||||||||txtccr2-butenal /first draft prepared by J. Kielborn and I. Mangelsdorf ; and K. Ziegler-Skylakakis1st ed.Geneva World Health Organizationc20081 online resource (55 p.)Concise international chemical assessment document,1020-6167 ;74"IPCS, International Programme on Chemical Safety.""Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization, and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals."9789200530743 92-4-153074-X Includes bibliographical references (p. 32-38).COVER; COPYRIGHT; TABLE OF CONTENTS; FOREWORD; 1. EXECUTIVE SUMMARY; 2. IDENTITY AND PHYSICAL/CHEMICAL PROPERTIES; 3. ANALYTICAL METHODS; 4. SOURCES OF HUMAN AND ENVIRONMENTAL EXPOSURE; 5. ENVIRONMENTAL TRANSPORT, DISTRIBUTION, TRANSFORMATION, AND ACCUMULATION; 6. ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE; 7. COMPARATIVE KINETICS AND METABOLISM IN LABORATORY ANIMALS AND HUMANS; 8. EFFECTS ON LABORATORY MAMMALS AND IN VITRO TEST SYSTEMS; 9. EFFECTS ON HUMANS; 10. EFFECTS ON OTHER ORGANISMS IN THE LABORATORY AND FIELD; 11. EFFECTS EVALUATION; 12. PREVIOUS EVALUATIONS BY IOMC BODIES; REFERENCESAPPENDICES2-Butenal (also known as crotonaldehyde) is an a,-unsaturated aldehyde and consequently a very reactive compound. It is a chemical intermediate used chiefly in the manufacture of sorbates, solvents, and, to a lesser extent, pharmaceutical products and aroma chemicals. This document studies the pharmacokinetics, environmental exposure, chemical toxicology and carcinogenicity of 2-butenal. However, to enable an understanding and evaluation of this aldehyde in the context of environmental health, other aldehydes, such as formaldehyde, acetaldehyde, and acrolein, are mentioned for comparison, whereConcise international chemical assessment document ;74.Two-butenalCrotonaldehydeEnvironmental aspectsCrotonaldehydeToxicologyCrotonaldehydePhysiological effectCrotonaldehydeEnvironmental aspects.CrotonaldehydeToxicology.CrotonaldehydePhysiological effect.363.1791Kielhorn J1695004Mangelsdorf I1695006Ziegler-Skylakakis K1702957World Health Organization.United Nations Environment Programme.International Labour Organisation.International Program on Chemical Safety.Inter-Organization Programme for the Sound Management of Chemicals.MiAaPQMiAaPQMiAaPQBOOK99108084751033212-butenal4087854UNINA