02415nam 2200589 a 450 991080790650332120240313141002.03-527-64564-01-283-89324-X3-527-64566-7(CKB)2550000000109402(EBL)1120902(OCoLC)805654697(SSID)ssj0000738117(PQKBManifestationID)12334535(PQKBTitleCode)TC0000738117(PQKBWorkID)10788950(PQKB)11614529(MiAaPQ)EBC1120902(Au-PeEL)EBL1120902(CaPaEBR)ebr10580287(CaONFJC)MIL420574(PPN)178875252(EXLCZ)99255000000010940220120730d2012 uy 0engur|n|---|||||txtccrLead optimization for medicinal chemists pharmacokinetic properties of functional groups and organic compounds /Florencio Zaragoza Dörwald1st ed.Weinheim, Germany Wiley-VCH20121 online resource (623 p.)Description based upon print version of record.3-527-33226-X Includes bibliographical references and index.pt. 1. Introduction -- pt. 2. The pharmacokinetic properties of compound classes.Small structural modifications can significantly affect the pharmacokinetic properties of drug candidates. This book, written by a medicinal chemist for medicinal chemists, is a comprehensive guide to the pharmacokinetic impact of functional groups, the pharmacokinetic optimization of drug leads, and an exhaustive collection of pharmacokinetic data, arranged according to the structure of the drug, not its target or indication. The historical origins of most drug classes and general aspects of modern drug discovery and development are also discussed. The index contains all the drug names and syPharmacokineticsDrug developmentPharmacokinetics.Drug development.615.19Dörwald Florencio Zaragoza875082MiAaPQMiAaPQMiAaPQBOOK9910807906503321Lead optimization for medicinal chemists4049105UNINA