04040nam 2200577 450 991080775620332120230120002246.00-12-801959-X(CKB)3710000000337361(EBL)1921148(SSID)ssj0001432653(PQKBManifestationID)11759441(PQKBTitleCode)TC0001432653(PQKBWorkID)11405722(PQKB)11182475(MiAaPQ)EBC1921148(Au-PeEL)EBL1921148(CaPaEBR)ebr11006351(CaONFJC)MIL695234(OCoLC)900464416(EXLCZ)99371000000033736120150127h20152015 uy 0engur|n|---|||||txtccrChemical modulators of protein misfolding and neurodegenerative disease /Pierfausto SeneciLondon, England :Academic Press,2015.©20151 online resource (260 p.)Description based upon print version of record.1-322-63952-3 0-12-801944-1 Includes bibliographical references at the end of each chapters and index.Cover; Title Page; Copyright Page; Dedication; Contents; Abbreviations; Chapter 1 - Chemical Modulators of Protein Misfolding, Neurodegeneration and Tau; 1.1 - Tau-targeted compounds; 1.1.1 - Tau Kinase Inhibitors; 1.1.2 - Tau O-GlcNAcylation Enhancers; 1.1.3 - Microtubule (MT)-binding Compounds; 1.2 - Ab-targeted compounds; 1.2.1 - γ-Secretase Inhibitors (GSIs) and Modulators (GSMs); 1.2.2 - Multi-targeted Neuroprotective and Proneurogenic Compounds; References; Chapter 2 - Targeting the Protein Quality Control (PQC) Machinery; 2.1 - Molecular chaperones, pqc, and neurodegeneration2.2 - Hsp272.3 - Hsp70; 2.3.1 - Hsp70 Inhibitors; 2.3.2 - Hsp70-BAG-1 Inhibitors; 2.4 - Hsp90; 2.4.1 - Hsp90 Inhibitors; 2.4.2 - Hsp90-Co-chaperone Complexes: Direct Inhibition; 2.4.3 - Hsp90-Co-chaperone Complexes: Indirect Inhibition; 2.5 - Recap; References; Chapter 3 - Targeting Proteasomal Degradation of Soluble, Misfolded Proteins; 3.1 - UPS-mediated degradation of misfolded proteins; 3.2 - CHIP; 3.3 - USP14; 3.4 - Recap; References; Chapter 4 - Targeting Unselective Autophagy of Cellular Aggregates; 4.1 - Macroautophagy mediated degradation of protein aggregates; 4.2 - mTORC14.3 - Small molecule enhancers of rapamycin (sMERs)4.4 - Recap; References; Chapter 5 - Targeting Selective Autophagy of Insoluble Protein Aggregates; 5.1 - Aggrephagy-mediated degradation of protein aggregates; 5.2 - p62; 5.3 - HDAC6; 5.4 - Recap; References; Chapter 6 - Targeting Assembly and Disassembly of Protein Aggregates; 6.1 - Disordered protein aggregates and ordered amyloid fibrils; 6.2 - Interfering with (neuro)toxic tau species in the aggregation process; 6.3 - Hsp110-driven disaggregation; 6.4 - Recap; References; Index This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer's and other tauopathies. Properties and development status of these moleculaNervous systemDegenerationNervous systemDegeneration.616.8047Seneci Pierfausto542916Seneci Pierfausto1960-542916MiAaPQMiAaPQMiAaPQBOOK9910807756203321Chemical modulators of protein misfolding and neurodegenerative disease4020085UNINA