04450nam 2200637Ia 450 991080735060332120200520144314.01-282-38209-897866123820930-470-82316-X0-470-82315-110.1002/97804708231639786612382093(CKB)1000000000799079(EBL)479834(OCoLC)609854660(SSID)ssj0000357175(PQKBManifestationID)11272671(PQKBTitleCode)TC0000357175(PQKBWorkID)10352392(PQKB)10658786(MiAaPQ)EBC479834(Au-PeEL)EBL479834(CaPaEBR)ebr10325816(CaONFJC)MIL238209(EXLCZ)99100000000079907920081022d2009 uy 0engurcn#nnn|||||txtrdacontentcrdamediacrrdacarrierBiocatalysis for the pharmaceutical industry discovery, development, and manufacturing /Junhua Tao, Guoqiang Lin, Andreas Liese1st ed.Singapore ;Hoboken Wileyc20091 online resource (x, 324 pages) illustrations0-470-82314-3 Includes bibliographical references and index.1. Enzymes and Their Synthetic Applications: An Overview -- 2. Expression Hosts for Enzyme Discovery and Production -- 3. Directed Enzyme Evolution and High-Throughput Screening -- 4. Applications of Reaction Engineering to Industrial Biotransformations -- 5. Chiral Synthesis of Pharmaceutical Intermediates Using Oxynitrilases -- 6. Expanding the Scope of Aldolases as Tools for Organic Synthesis -- 7. Synthetic Applications of Ketoreductases and Alcohol Oxidases --8. Applications of Nitrile Hydratases and Nitrilases -- 9. Biosynthesis of Drug Metabolites -- 10. Application of Whole-Cell Biotransformation in the Pharmaceutical Industry -- 11. Combinatorial Biosynthesis of Pharmaceutical Natural Products -- 12. Metabolic Engineering for the Development and Manufacturing of Pharmaceuticals -- 13. Multimodular Synthases and Supporting Enzymes for Chemical Production -- 14. Green Chemistry with Biocatalysis for Production of Pharmaceuticals.Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.Pharmaceutical biotechnologyEnzymesBiotechnologyPharmaceutical biotechnology.EnzymesBiotechnology.615.19Tao Junhua879055Lin Guoqiang1704292Liese A(Andreas)879057MiAaPQMiAaPQMiAaPQBOOK9910807350603321Biocatalysis for the pharmaceutical industry4090169UNINA