08155nam 22015973u 450 991080699630332120220913225323.01-283-17785-497866131778581-119-97542-51-119-97543-3(CKB)2550000000041124(EBL)697595(OCoLC)746324285(SSID)ssj0000534944(PQKBManifestationID)11348599(PQKBTitleCode)TC0000534944(PQKBWorkID)10526920(PQKB)11302623(MiAaPQ)EBC697595(PPN)233220097(EXLCZ)99255000000004112420131014d2011|||| u|| |engur|n|---|||||txtccrChemistry and Biochemistry of Oxygen Therapeutics[electronic resource] From Transfusion to Artificial BloodHoboken Wiley20111 online resource (476 p.)Description based upon print version of record.0-470-68668-5 Chemistry and Biochemistry of Oxygen Therapeutics; Contents; List of Contributors; Preface; 1. Introduction; References; Part I. Oxygen: Chemistry, Biochemistry, Physiology and Toxicity; 2. Hemoglobin Reactivity and Regulation; 2.1 Introduction; 2.2 Oxygen Loading and Transport; 2.3 NO Reactivity with Hb; 2.4 Hb Oxidation; 2.5 Nitrite Reactivity with Hb; 2.6 Amino-acid Determinants of Hb Reactivity: Natural and Engineered Hbs; 2.6.1 Modulation of Oxygen Affinity and Cooperativity; 2.6.2 NO Reactivity and Oxidation; 2.7 Conclusion; Acknowledgments; References3. The Major Physiological Control Mechanisms of Blood Flow and Oxygen Delivery3.1 Introduction; 3.2 Autoregulation of Blood Flow to Changes in Perfusion Pressure; 3.3 Metabolic Regulation of Blood Flow; 3.4 O2 Transport; 3.5 O2 Delivery; 3.6 Endothelial Control of Vasomotor Tone; 3.7 Effect of Cell-free Hb on Endothelial Function; 3.8 Hypoxic Hypoxia; 3.9 Carbon Monoxide Hypoxia; 3.10 Anemia; 3.11 Conclusion; References; 4. The Main Players: Hemoglobin and Myoglobin; Nitric Oxide and Oxygen; 4.1 Introduction; 4.2 Role of Mammalian Mb in O2 Homeostasis4.3 WhatLfs Missing in the Mb Knockout Mouse4.4 Evolutionary Origins of Mb and the Nitrogen Cycle; 4.5 Human Hb: Evolved Sensor of pO2 and Redox; 4.6 Broad Reactivity and Influence of NO: Lessons from the Microcosm Hb; 4.7 Some Fish Demonstrate a Fundamental "Need" for Hb-dependent NO Cycling, as in Humans; 4.8 Reactions of NO with Hb that Preserve NO Bioactivity; 4.9 Mammalian RBC/Hb.NO Interactions; 4.10 A Mutant Mouse Challenges the SNO-Hb Hypothesis, but does not Overthrow it; 4.11 Signaling by Hb-derived SNO: A Metabolically Responsive, Regulated Pathway4.12 Signaling by Hb-derived SNO: Pathway Complexity Revealed by Multiple Defects in Disease States4.13 Therapeutic Implications of the Hb.NO Signaling System; 4.14 HBOCs, NO, and SNO; 4.15 Other Gaseous Hb Ligands of Potential Therapeutic Significance; 4.16 NO-related Enzymatic Activities of Hb: Reconciling Nitrite Reductase and SNO Synthase Functions; 4.17 Measuring Biologically Relevant Hb.NO Adducts; 4.18 Conclusion; Acknowledgments; References; 5. The Role of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury; 5.1 Introduction5.2 Redox System and Free Radicals in Biological Systems5.3 Pathophysiology of Ischemia/Reperfusion Injury; 5.3.1 Cell Death; 5.3.2 The Inflammatory Response; 5.4 Protection Against I/R Injury; 5.4.1 Ischemic Pre- and Post-conditioning; 5.4.2 Pharmacological Conditioning; 5.4.2.1 The Protective Role of ROS and Antioxidants; 5.4.2.2 The Protective Role of NO; 5.4.2.3 NO-based Therapies for I/R Injury; 5.5 Conclusion; Acknowledgments; References; Part II. Medical Needs for Oxygen Supply; 6. Acute Traumatic Hemorrhage and Anemia; 6.1 Introduction; 6.2 Blood Transfusion in Trauma6.2.1 Massive TransfusionHuman blood performs many important functions including defence against disease and transport of biomolecules, but perhaps the most important is to carry oxygen - the fundamental biochemical fuel - and other blood gases around the cardiovascular system. Traditional therapies for the impairment of this function, or the rapid replacement of lost blood, have centred around blood transfusions. However scientists are developing chemicals (oxygen therapeutics, or "blood substitutes") which have the same oxygen-carrying capability as blood and can be used as replacements for blood transfusion or to tHemoglobins - therapeutic useHemoglobins -- therapeutic useNitric oxide - Physiological effectNitric oxide -- Physiological effectOxigen - Physiological effectOxigen -- Physiological effectOxygen - bloodOxygen -- bloodOxygen ConsumptionOxygen ConsumptionOxygen Inhalation Therapy - methodsOxygen Inhalation Therapy -- methodsOxygen therapyOxygen therapySCIENCE / Life Sciences / BiochemistryOxygen therapyPhysiological effectOxygenPhysiological effectNitric oxideMetabolic PhenomenaRespiratory TherapyInvestigative TechniquesBody FluidsGlobinsChalcogensBlood ProteinsGasesTherapeuticsFluids and SecretionsElementsHemeproteinsInorganic ChemicalsProteinsAmino Acids, Peptides, and ProteinsAnatomyOxygenBloodOxygen ConsumptionHemoglobinsMethodsOxygen Inhalation TherapyHealth & Biological SciencesHILCCPharmacy, Therapeutics, & PharmacologyHILCCHemoglobins - therapeutic use.Hemoglobins -- therapeutic use.Nitric oxide - Physiological effect.Nitric oxide -- Physiological effect.Oxigen - Physiological effect.Oxigen -- Physiological effect.Oxygen - blood.Oxygen -- blood.Oxygen Consumption.Oxygen Consumption.Oxygen Inhalation Therapy - methods.Oxygen Inhalation Therapy -- methods.Oxygen therapy.Oxygen therapy.SCIENCE / Life Sciences / Biochemistry.Oxygen therapyPhysiological effectOxygenPhysiological effectNitric oxideMetabolic PhenomenaRespiratory TherapyInvestigative TechniquesBody FluidsGlobinsChalcogensBlood ProteinsGasesTherapeuticsFluids and SecretionsElementsHemeproteinsInorganic ChemicalsProteinsAmino Acids, Peptides, and ProteinsAnatomyOxygenBloodOxygen ConsumptionHemoglobinsMethodsOxygen Inhalation TherapyHealth & Biological SciencesPharmacy, Therapeutics, & Pharmacology615.8/36615.836SCI007000bisacshMozzarelli Andrea957272Bettati Stefano1602161AU-PeELAU-PeELAU-PeELBOOK9910806996303321Chemistry and Biochemistry of Oxygen Therapeutics3926044UNINA