05242nam 2200637Ia 450 991080684700332120200520144314.01-281-76266-097866117626670-08-095152-X0-08-055819-4(CKB)1000000000547726(EBL)404862(OCoLC)476220392(SSID)ssj0000211489(PQKBManifestationID)12043443(PQKBTitleCode)TC0000211489(PQKBWorkID)10311844(PQKB)11631291(MiAaPQ)EBC404862(PPN)182574830(EXLCZ)99100000000054772620080630d2008 uy 0engur|n|---|||||txtrdacontentcrdamediacrrdacarrierNMR spectroscopy in pharmaceutical analysis /edited by Ulrike Holzgrabe, Iwona Wawer, Bernd DiehlOxford Elsevier20081 online resource (525 pages)0-444-53173-4 Includes bibliographical references and index.Front Cover; NMR Spectroscopy in Pharmaceutical Analysis; Copyright Page; Table of Contents; Preface; List of Contributors; List of Editors; Part I FUNDAMENTALS AND TECHNIQUES; Chapter 1 Principles in NMR Spectroscopy; 1 Short History; 2 The NMR Experiment; 2.1 Excitation, relaxation and sensitivity; 2.2 Relaxation; 3 Chemical Shift; 3.1 Electronic density; 3.2 Anisotropy; 3.3 Mesomerism; 3.4 Steric effects; 4 Calibration and Relative Scale ppm; 5 Spin-Spin Coupling; 5.1 The coupling constant; 5.2 Multiplicity; 5.3 Roof effect; 5.4 Angular dependence of the coupling constant5.5 Heteronuclear coupling; 5.6 13C NMR satellites in 1H NMR spectra; 6 Heteronuclear Spectra; 6.1 Decoupling; 6.2 Quantitative heteronuclear NMR; 7 Molecular Dynamics; 7.1 Deuterium exchange and solvent effects; 8 Chemical Derivatisation; 9 Stereochemistry; 9.1 Diastereomerism; 9.2 Atrop or axial chirality; 9.3 Enantiomeric excess; 9.4 Diastereotopy; 10 Two-dimensional Methods for Structure Elucidation; 11 Experimental Data; Chapter 2 Quantitative NMR in the Solution State NMR; 1 Introduction; 2 Basics; 3 Quantitative NMR Spectroscopy; 3.1 Relative method; 3.2 Absolute method; 4 Validation4.1 Linearity; 4.2 Robustness; 4.3 Specificity and selectivity; 4.4 Accuracy; 4.5 Precision; 4.6 Measurement uncertainty; 4.7 Round robin tests; 5 Sensitivity; 6 Conclusion; Chapter 3 qNMR in Solid State; 1 Introduction to Solid-state NMR; 2 Quantitative Aspects of Solid-state NMR, Protocol for Quantitation; 3 An Example: Quantitation of Pseudoephedrine in Dosage Form; 4 Quantitation of Polymorphs and Formulated Drugs; Chapter 4 Microcoil Nuclear Magnetic Resonance Spectroscopy; 1 Introduction; 2 Intrinsic NMR Sensitivity; 3 Development of Small Coils for High-Resolution NMR3.1 Saddle/Helmholtz coils; 3.2 Solenoidal coils; 3.3 Planar RF coils; 3.4 Novel microcoil designs; 3.5 High-temperature superconducting microprobes; 4 Sensitivity Comparisons; 5 Nanoliter Volume Applications of RF Microcoils - Hyphenated cITP-NMR; 6 Microliter Volume Applications of RF Microcoils; 6.1 Helmholtz/saddle coils; 6.2 Solenoidal coils; 6.3 Superconducting microcoils; 7 Hyphenation of Microseparation Techniques with Microliter NMR Detection; 8 Multiple Coil Probeheads; 9 Solid-State Applications of Small Coils; 10 ConclusionChapter 5 qNMR Spectroscopy in Drug Analysis - A General View; 1 Introduction; 2 NMR Spectroscopy in International Pharmacopoeias; 2.1 Identification of drugs; 2.2 Tests; 2.3 Assay; 3 Validation; 4 Conclusions; Part II GENERAL APPLICATIONS; Chapter 1 Investigation of Multi-Component Drugs by NMR Spectroscopy; 1 Introduction; 1.1 Solvent; 1.2 pH value; 1.3 Temperature; 1.4 Auxiliary reagents; 1.5 Limitations; 2 Codergocrine Mesylate; 2.1 1H NMR spectroscopy; 2.2 13C NMR spectroscopy; 2.3 High-performance liquid chromatography; 2.4 HPLC versus NMR spectroscopy; Chapter 2 NMR Applications for Polymer CharacterisationFor almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems often resulting in insufficient methods.Nuclear magnetic resonance spectroscopyDrugsAnalysisNuclear magnetic resonance spectroscopy.DrugsAnalysis.615.19615.1901615.1901Holzgrabe U(Ulrike)312860Wawer I(Iwona)312861Diehl B(Bernd)1649010MiAaPQMiAaPQMiAaPQBOOK9910806847003321NMR spectroscopy in pharmaceutical analysis4102113UNINA