04147nam 2200733 a 450 991080616250332120240516065051.09786613694461978128078407112807840759780470720738047072073597804707184210470718420(CKB)1000000000688145(EBL)703912(OCoLC)797918492(SSID)ssj0000715489(PQKBManifestationID)11435131(PQKBTitleCode)TC0000715489(PQKBWorkID)10701713(PQKB)11341815(MiAaPQ)EBC703912(Au-PeEL)EBL703912(CaPaEBR)ebr10575664(CaONFJC)MIL369446(Perlego)2776629(EXLCZ)99100000000068814519831122d1982 uy 0engur|n|---|||||txtccrSubstance P in the nervous system1st ed.London Pitman ;Summit, N.J., USA Distributed in North America by Ciba Pharmaceutical Co., Medical Education Administration19821 online resource (362 p.)Ciba Foundation symposium ;91"Editors: Ruth Porter (organizer) and Maeve O'Connor"--P. v.9780470664087 0470664088 9780272796559 0272796557 Includes bibliographical references and indexes.Substance P in the nervous system; Contents; Introduction; Chemical neurotransmission-yesterday and today; Role of substance P as a sensory transmitter in spinal cord and sympathetic ganglia; Discussion; Substance P in peripheral sensory processes; Discussion; Localization of substance P in neuronal pathways; Discussion; Distribution of substance P in brain and periphery and its possible role as a co-transmitter; Discussion; Regulation of substance P expression and metabolism in vivo and in vitro; Discussion; GENERAL DISCUSSION; Coexistence of transmittersSubstance P in nerve tissue in the gut Discussion; Biosynthesis, axonal transport and turnover of neuronal substance P; Discussion; Enzymic inactivation of substance P in the central nervous system; Discussion; Substance P receptors in the nervous system and possible receptor subtypes; Discussion; Relation of substance P to pain transmission: neurophysiological evidence; Discussion; Substance P in nociceptive sensory neurons; Discussion; If substance P fails to fulfil the criteria as a neurotransmitter in somatosensory afferents, what might be its function?; DiscussionModulation of cholinergic transmission by substance PDiscussion; The striatonigral substance P pathway and dopaminergic mechanisms; Discussion; Relation of substance P to stress and catecholamine metabolism; Discussion; Behavioural effects of substance P through dopaminergic pathways in the brain; Discussion; FINAL GENERAL DISCUSSION; Substance P antagonists; tumour cell lines and substance P; substance P and other tachykinins; substance P and clinical pain syndromes; substance P and neuronal systems; Index of contributors; Subject indexThe Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world. Ciba Foundation symposium ;91.Substance PCongressesNeurologyCongressesSubstance PNeurology599/.0188Porter Ruth64811O'Connor Maeve284912MiAaPQMiAaPQMiAaPQBOOK9910806162503321Substance P in the nervous system1963079UNINA