05476nam 2200673Ia 450 991078499160332120230617001145.01-281-86697-097866118669761-86094-717-4(CKB)1000000000406993(EBL)1214961(SSID)ssj0000199333(PQKBManifestationID)12027869(PQKBTitleCode)TC0000199333(PQKBWorkID)10184501(PQKB)10649608(MiAaPQ)EBC1214961(WSP)00000048 (Au-PeEL)EBL1214961(CaPaEBR)ebr10713364(CaONFJC)MIL186697(OCoLC)815741996(EXLCZ)99100000000040699320051124d2005 uy 0engur|n|---|||||txtccrMatrix metalloproteinases in the central nervous system[electronic resource] /editors, Katherine Conant, Paul E. GottschallLondon Imperial College Press ;Hackensack, NJ Distributed by World Scientificc20051 online resource (346 p.)Description based upon print version of record.1-86094-559-7 Includes bibliographical references and index.CONTENTS; Foreword; I. A Brief Overview; Chapter 1. The Matrix Metalloproteinases and Their Inhibitors Madeleine M. Handsley, Janet Cross, Jelena Gavrilovic, and Dylan R. Edwards; 1. Introduction; 2. The MMP Family; 3. Regulation of MMP Activity; 4. Endogenous Inhibitors of Metalloproteinases; 5. Novel Roles for MMPs; 6. ECM Targets in the CNS; 7. Generation of Matricryptic Sites in ECM Components; 8. Growth Factor Liberation from ECM "Stores"; 9. Chemokine Gradient Generation; 10. Blood-Brain Barrier Substrates for MMPs; 11. Conclusion; References; II. Regulation of MMP ExpressionChapter 2. Genetic Regulation of the Matrix Metalloproteinases and Related Proteins Tammie Roy and Elizabeth A. Milward1. Introduction; 2. Stimuli Triggering Alterations in MMP Gene Expression; 3. Alterations in Other MMPs; 4. Neurotransmitters; 5. Cell-Cell and Cell-Matrix Interactions; 6. Physical and Biochemical Stress; 7. Suppressive Factors; 8. Feedback Control; 9. Signalling Cascades Involved in Regulating MMP Gene Expression; 9.1. The MAPK pathway; 9.2. The NF-κB pathway; 9.3. The 'JAK/STAT' pathway; 9.4. The PI3K/Akt system; 9.5. The Smad pathway9.6. Cross-talk and competition between pathways9.7. Pathways operating in the nervous system; 10. Genetic Elements Regulating MMP Gene Expression; 10.1. Constitutive and inducible transcription factors; 10.2. Orchestrating multigene responses; 10.3. AP-1 binding sites and related elements; 10.4. Other promoter elements; 10.5. Chromatin remodelling; 11. Regulation of the MMP-2, MMP-11 and MMP-14 (MT1-MMP) Genes; 11.1. The MMP-2 gene; 11.2. The MMP-11 gene; 11.3. The MMP-14 gene; 12. Regulation of ADAMs Family Gene Expression; 13. Regulation of TIMP Gene Expression14. Inverse Regulation of MMPs and TIMPs15. Regulation of TIMPs Independent of MMP Inhibitory Functions; 16. Post-Transcriptional Regulation of MMP Expression; 17. Regulation of MMP Gene Expression in the Healthy Nervous System; 18. Neuronal Expression; 19. Astrocyte Expression; 20. Microglial Expression; 21. Endothelial and Other Cells; 22. Oligodendrocyte and Schwann Cell Expression; 23. Expression of TIMPs in the Nervous System; 24. Expression in Nervous System Development and Plasticity; 25. MMP Gene Regulation in Nervous System Injury and Disease26. Regulation in Nervous System Malignancies27. Regulation in Nervous System Injury; 28. Genetic Polymorphisms and MMP Expression; 29. Conclusion; References; Chapter 3. Post-Translational Modification Zezong Gu, Marcus Kaul, and Stuart A. Lipton; 1. Introduction; 2. Cysteine Switch Mechanism; 3. Modification of MMPs by S-Nitrosylation; 4. S-Nitrosylation Leads to MMP-9 Activation In Vitro; 5. NO-Induced Subsequent Oxidation; 6. Peptide Mass Fingerprinting Analysis of Cysteine Residue Post-Translational Modifications; 7. Structural Model of S-Nitrosylation of MMPs8. MMPs in Neurological DiseasesThis book presents the reader with an understanding of the role played by matrix metalloproteinases (MMPs) in the normal and diseased central nervous system (CNS). These enzymes may be important to brain development, and may also contribute to tissue destruction, which is observed with inflammatory and degenerative conditions of the brain. The book provides a background on the biology of MMPs, and on the stimuli and conditions that are linked to an increase in their production and activity. It describes the targets of MMPs, which include matrix proteins such as collagen, soluble cytokines and MetalloproteinasesCentral nervous systemExtracellular matrix proteinsMetalloproteinases.Central nervous system.Extracellular matrix proteins.612.8Conant Katherine1542278Gottschall Paul E1542279MiAaPQMiAaPQMiAaPQBOOK9910784991603321Matrix metalloproteinases in the central nervous system3794865UNINA06413nam 22008415 450 991079765410332120220325232922.01-137-45251-X10.1057/9781137452511(CKB)3710000000483889(EBL)4000989(SSID)ssj0001617115(PQKBManifestationID)16348979(PQKBTitleCode)TC0001617115(PQKBWorkID)14921854(PQKB)10181790(SSID)ssj0001554261(PQKBManifestationID)16181018(PQKBTitleCode)TC0001554261(PQKBWorkID)14175493(PQKB)10381951(DE-He213)978-1-137-45251-1(MiAaPQ)EBC4000989(EXLCZ)99371000000048388920151230d2015 u| 0engur|n|---|||||txtccrMixed methods research in poverty and vulnerability[electronic resource] sharing ideas and learning lessons /edited by Keetie Roelen, Laura Camfield1st ed. 2015.London :Palgrave Macmillan UK :Imprint: Palgrave Macmillan,2015.1 online resource (296 p.)Description based upon print version of record.1-349-68681-6 1-137-45250-1 Includes bibliographical references at the end of each chapters and index.""Cover""; ""Mixed Methods Research in Poverty and Vulnerability""; ""Contents""; ""List of Tables and Figures""; ""Acknowledgements""; ""Notes on Contributors""; ""1: Introduction""; ""Background""; ""Credibility""; ""Complexity""; ""Usability""; ""This volume""; ""References""; ""Section I: Poverty Measurement""; ""2: Mixed Methods in Poverty Measurement: Qualitative Perspectives on the ?Necessities of Life? in the 2012 PSE-UK Survey""; ""Introduction""; ""Mixed methods approaches in poverty research: Bridging the methodological divide?""; ""The logic of mixed methods enquiry""""Mixed methods in poverty research""""Quantifying the ?necessities of life? in Britain""; ""What is the consensual approach to poverty measurement?""; ""Quantifying the ?necessities of life? in the 2012 PSE-UK study""; ""Qualitative perspectives on the ?necessities of life ?in Britain""; ""What are the applications of focus group methods in the 2012 PSE-UK study?""; ""What then can qualitative methods contribute in understanding public views on necessities?""; ""Methodological issues in determining consensus""; ""Cognition issues in determining the ?necessities of life?""""Need, entitlement and the abstract individual""""Discussion and conclusions""; ""Note""; ""References""; ""3: Deprivation and Social Citizenship: The Objective Significance of Lived Experience""; ""Introduction""; ""Towards a new analytical framework for measuring deprivation""; ""The nexus between deprivation and citizenship""; ""The objective significance of lived experience""; ""Lived experiences of deprivation: An integrated mixed methods approach""; ""Conclusion""; ""Notes""; ""References""""4: Bringing Context to Poverty in Rural Rwanda: Added Value and Challenges of Mixed Methods Approaches""""Introduction""; ""Bridging the divide in poverty research""; ""Mixed methods research for bridging the divide""; ""The application of mixed methods to research rural wellbeing in Rwanda""; ""Results and discussion""; ""Initial qualitative exploration""; ""Quantitative representation of heterogeneity in sample population""; ""Further qualitative analysis: Relational and subjective wellbeing and causes of change""; ""Reflections on the application of integrated mixed methods""""Conclusions""""Note""; ""References""; ""5: Measuring the Resilience of Rural Households in Burkina Faso""; ""Introduction""; ""Conceptual background""; ""Resilience: More than ?bouncing back?""; ""Links between ?resilience? and ?food security?""; ""Application of mixed methods to ?resilience?""; ""Methodological approach""; ""Overview""; ""Scope of the study sample""; ""Estimating household?s food security levels (outcome indicator)""; ""Developing and measuring quantitative process indicators of resilience""; ""Exploring enabling factors""; ""Data analysis""; ""Limitations of the study""""Results""The added value of mixed methods research in poverty and vulnerability is now widely established. Nevertheless, gaps and challenges remain. This volume shares experiences from research in developed and developing country contexts on how mixed methods approaches can make research more credible, usable and responsive to complexity.  .Economic developmentSocial sciencesDevelopment economicsPovertyDevelopment Theoryhttps://scigraph.springernature.com/ontologies/product-market-codes/913010Methodology of the Social Scienceshttps://scigraph.springernature.com/ontologies/product-market-codes/X17000Development Economicshttps://scigraph.springernature.com/ontologies/product-market-codes/W42000Development Studieshttps://scigraph.springernature.com/ontologies/product-market-codes/913000Development Aidhttps://scigraph.springernature.com/ontologies/product-market-codes/913040Science, Humanities and Social Sciences, multidisciplinaryhttps://scigraph.springernature.com/ontologies/product-market-codes/A11007Economic development.Social sciences.Development economics.Poverty.Development Theory.Methodology of the Social Sciences.Development Economics.Development Studies.Development Aid.Science, Humanities and Social Sciences, multidisciplinary.305.5/69072SOC024000SOC042000SOC045000bisacshRoelen Keetieedthttp://id.loc.gov/vocabulary/relators/edtCamfield Lauraedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910797654103321Mixed methods research in poverty and vulnerability3847970UNINA01291nam 2200397 450 991082982160332120230222125951.01-119-86961-71-119-86959-5(MiAaPQ)EBC7100687(Au-PeEL)EBL7100687(CKB)24949917500041(EXLCZ)992494991750004120230222d2023 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierAdvances in semiconductor technologies selected topics beyond conventional CMOS /edited by An ChenHoboken, New Jersey :Wiley-IEEE Press,[2023]©20231 online resource (371 pages)Print version: Chen, An Advances in Semiconductor Technologies Newark : John Wiley & Sons, Incorporated,c2022 9781119869580 Includes bibliographical references and index.SemiconductorsSemiconductors.621.3815/2Chen An(Electronics engineer),MiAaPQMiAaPQMiAaPQBOOK9910829821603321Advances in semiconductor technologies4067074UNINA