03090nam 2200577 450 991079744550332120200923020339.03-11-043658-210.1515/9783110436587(CKB)3710000000455826(DE-B1597)456526(OCoLC)979746048(DE-B1597)9783110436587(MiAaPQ)EBC5024742(Au-PeEL)EBL5024742(CaPaEBR)ebr11567603(EXLCZ)99371000000045582620110504d2009 uy| 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierMetal-carbon bonds in enzymes and cofactors /edited by Astrid Sigel, Helmut Sigel, and Roland K.O. SigelCambridge, UK :RSC Publishing,2009.1 online resourceMetal ions in life sciences,1559-0836 ;volume 63-11-044279-5 Includes bibliographical references and indexes.Organometallic chemistry of B12 coenzymes -- Cobalamin- and corrinoid-dependent enzymes -- Nickel-alkyl bond formation in the active site of methyl-coenzyme M reductase -- Nickel-carbon bonds in acetyl-coenzyme a synthases/carbon monoxide dehydrogenases -- Structure and function of [NiFe]-hydro-genases -- Carbon monoxide and cyanide ligands in the active site of [FeFe]-hydrogenases -- Carbon monoxide as intrinsic ligand to iron in the active site of [Fe]-hydrogenase -- Dual role of heme as cofactor and substrate in the biosynthesis of carbon monoxide -- Copper-carbon bonds in mechanistic and structural probing of proteins as well as in situations where copper is a catalytic or receptor site -- Interaction of cyanide with enzymes containing vanadium, manganese, non-heme iron, and zinc -- Reaction mechanism of the molybdenum hydroxylase xanthine oxidoreductase: evidence against the formation of intermediates having metal-carbon bonds.The occurrence of a wide variety of metal-carbon bonds in living organisms, ranging from bacteria to humans, is only recently recognized. Of course, the historical examples are the B12 coenzymes containing cobalt-carbon bonds, but now such bonds are also known for nickel, iron, copper, and other transition metal ions. There is no other comparable book; MILS-6, written by 17 experts, summarizes the most recent insights into this fascinating topic.Metal ions in life sciences ;v. 6.MetalloenzymesCoenzymesOrganometallic compoundsVitamin B12Metalloenzymes.Coenzymes.Organometallic compounds.Vitamin B12.572.7Sigel AstridSigel HelmutSigel Roland K. O.MiAaPQMiAaPQMiAaPQBOOK9910797445503321Metal-carbon bonds in enzymes and cofactors3841465UNINA