05544nam 2200673 450 991079733640332120200909225244.00-12-803120-40-12-803119-0(CKB)3710000000453344(EBL)2120151(SSID)ssj0001550382(PQKBManifestationID)16166286(PQKBTitleCode)TC0001550382(PQKBWorkID)14810841(PQKB)10168438(MiAaPQ)EBC2120151(Au-PeEL)EBL2120151(CaPaEBR)ebr11083664(CaONFJC)MIL822713(OCoLC)918625276(PPN)192174479(EXLCZ)99371000000045334420150812h20152015 uy 0engur|n|---|||||txtccrCytochrome P450 function and pharmacological roles in inflammation and cancer /edited by James P. Hardwick, S. J. Enna, Lynn Lecount ; contributors, Mohamed A. Abdelmegeed [and thirty-three others]First edition.Amsterdam, [Netherlands] :Academic Press,2015.©20151 online resource (506 p.)Advances in Pharmacology,1054-3589 ;Volume 74Description based upon print version of record.Includes bibliographical references at the end of each chapters and index.Front Cover; Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer; Copyright; Contents; Contributors; Preface; References; Chapter One: Role of Cytochrome P450 Monooxygenase in Carcinogen and Chemotherapeutic Drug Metabolism; 1. Introduction; 2. Historical Aspects of Chemical Carcinogenesis Leading to Discovery of the Cytochrome P450 Monooxygenase; 2.1. Cytochromes P450; 2.2. Butter Yellow Carcinogenesis; 2.3. PAH Carcinogenesis: Protein Adducts and Induction of Metabolism3. Cytochrome P450-Monooxygenase-Mediated Activation of Procarcinogen and Chemotherapeutic Prodrugs3.1. Aromatic Azo Compounds; 3.2. Polycyclic Aromatic Hydrocarbons; 3.3. Polychlorinated Biphenyls; 3.3.1. Polychlorinated Biphenyls with Low Chlorine Content; 3.3.2. Highly Chlorinated Biphenyls; 3.4. Vinyl Chloride; 3.5. Nitrosamines; 3.6. Furans; 3.7. Chemotherapeutic Prodrugs; 3.7.1. Cyclophosphamide; 3.7.2. Procarbazine and Other Hydrazine Derivatives; 3.7.3. Anthracycline Antibiotics; 4. Factors That Regulate Changes in Gene Expression: Differences Between Rodents and Humans4.1. Hepatic Nuclear Receptors and Enzyme Induction4.2. Differences Between Rodent and Human Receptors; 4.3. CAR Splice Variants and Ligand Specificity; 4.4. Exogenous Compounds Acting on the PPAR; 4.5. Underlying Regulation by Other Hormones and Transcription Factors; 4.6. Effects of Environmental Agents; 5. Polymorphic Cytochrome P450 Variants Impacting Expression and Cancer Susceptibility; 5.1. Cytochrome P4501A1 and Glutathione S-Transferase M1; 5.2. Cytochrome P4502D6 and Cytochrome P4502E1; 6. Conclusion; Conflict of Interest; Acknowledgment; ReferencesChapter Two: Involvement of Cytochrome P450 in Reactive Oxygen Species Formation and Cancer1. Introduction; 2. Reactive Oxygen Species Formation in Biological Systems; 2.1. Oxygen Reactivity and Formation of Reactive Oxygen Species; 2.2. Types of Reactive Oxygen Species and Their Reactivities; 2.2.1. Superoxide Radical Anion; 2.2.2. Hydrogen Peroxide; 2.2.3. Hydroxyl Radical; 2.2.4. Peroxyl Radical; 2.2.5. Singlet Oxygen; 3. Protective Agents to Combat Reactive Oxygen Species; 3.1. Antioxidants; 3.1.1. Antioxidant Enzymes; 3.1.2. Nonenzymatic Antioxidants; 3.1.2.1. Glutathione3.1.2.2. Vitamin E, Vitamin C, and β-Carotene3.1.2.3. Lycopene; 3.1.2.4. Melatonin; 4. CYP Catalytic Cycle and Involvement of CYP Enzymes in Reactive Oxygen Species Formation; 5. Roles of Reactive Oxygen Species in Cancer; 5.1. Reactive Oxygen Species and Cell Signaling; 6. Relationship Between CYP Enzymes and Cancer; 6.1. CYP Expression in Neoplastic Tissues; 6.2. CYP Polymorphism and Cancer Risk; 6.3. CYP Enzymes and Chemical Carcinogenesis; 6.4. CYP Enzymes and Cancer Therapy; 7. Conclusion; Conflict of Interest; Acknowledgments; ReferencesChapter Three: Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases<i> Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer</i>, the latest volume in the <i>Advances in Pharmacology</i> series, presents not only the function of cytochrome P450 but also its pharmacological roles in inflammation and cancer. <br><br><ul><li>Contains contributions from the best authors in the field</li><li>Ideal reference for those conducting research in cancer, inflammation, cytochrome P450, metabolism, liver disease, and oxidative stress</li><li>Provides an essential resource for pharmacologists, immunologists, and biochemists</li></ul>Advances in pharmacology (San Diego, Calif.) ;Volume 74.Cytochrome P-450Cytochrome P-450.572.7Hardwick James P.Enna S. J.Lecount LynnAbdelmegeed Mohamed A.MiAaPQMiAaPQMiAaPQBOOK9910797336403321Cytochrome P450 function and pharmacological roles in inflammation and cancer1517911UNINA