05564nam 2200697 a 450 991078089180332120230725041534.01-282-76042-49786612760426981-283-347-1(CKB)2490000000001766(EBL)1681601(OCoLC)729020441(SSID)ssj0000420069(PQKBManifestationID)12148809(PQKBTitleCode)TC0000420069(PQKBWorkID)10385907(PQKB)11254798(MiAaPQ)EBC1681601(WSP)00000630 (Au-PeEL)EBL1681601(CaPaEBR)ebr10422550(CaONFJC)MIL276042(EXLCZ)99249000000000176620100604d2010 uy 0engur|n|---|||||txtccrHuman oncogenic viruses[electronic resource] /editors, Jing-Hsiung James Ou, T. S. Benedict YenNew Jersey World Scientificc20101 online resource (352 p.)Description based upon print version of record.981-283-346-3 Includes bibliographical references and index.Contents; Foreword; Preface; Chapter 1 Oncogenic Viruses, Cellular Transformation and Human Cancers Yanyan Zheng and Jing-hsiung James Ou; 1. Introduction and Historical Aspects; 2. Human Oncogenic Viruses; 2.1. Hepatitis B Virus (HBV); 2.2. Hepatitis C Virus (HCV); 2.3. Human Papilloma Virus (HPV); 2.4. Epstein-Barr Virus (EBV); 2.5. Kaposi's Sarcoma-associated Herpesvirus (KSHV); 2.6. Human T-cell Leukemia Virus-1 (HTLV-1); 3. Mechanisms of Virus-induced Cellular Transformation; 3.1. Perturbation of Signaling Pathways; 3.1.1. Mimicking the signaling ligands3.1.2. Mimicking the cellular signaling receptors3.1.3. Mimicking the intracellular signaling adaptors; 3.1.4. Activation of cell surface receptors; 3.2. Deregulation of the Cell Cycle; 3.2.1. Abrogation of the RB function; 3.2.2. Enhancement of CDK activities; 3.2.3. Targeting of cyclin; 3.3. Escape of Apoptosis; 3.3.1. Inactivation of the "gatekeeper" p53; 3.3.2. Expression of viral version of Bcl-2 (vBcl-2); 3.4. Immortalization of Cells; 3.5. Induction of Genetic Instability; 3.6. Insertional Mutagenesis; 3.7. Induction of Chronic Inflammation; 4. Concluding Remarks; BibliographyChapter 2 Hepatitis B Virus and Hepatocellular Carcinogenesis T. S. Benedict Yen1. Hepatitis B Virus and Hepatocellular Carcinoma; 2. Biology and Epidemiology of HBV; 3. HBV Virology; 4. Prevention and Treatment of HBV; 5. Mechanisms of HBV Carcinogenesis; 5.1. Overview; 5.2. HBV-specific Factors; 5.2.1. X protein; 5.2.1.1. Function of X protein in the HBV life cycle; 5.2.1.2. Effect of X protein on transcription; 5.2.1.3. Effect of X protein on viral replication; 5.2.1.4. X protein and DDB1; 5.2.1.5. X-protein carcinogenesis; 5.2.2. Other viral proteins potentially involved in carcinogenesis5.2.2.1. Truncated MSP5.2.2.2. preS2 mutants; 5.2.2.3. Core gene mutants; 5.2.3. Insertional mutagenesis; 5.3. Role of Liver Injury and Inflammation; 5.4. Dietary Carcinogens; 5.5. Other Aspects of HBV Oncogenesis; 5.5.1. Role of genotypes; 5.5.2. Role of sex hormones; 6. Summary; Note; References; Chapter 3 Molecular Mechanism of Hepatitis C Virus Carcinogenesis Keigo Machida, Jing-hsiung James Ou and Michael M. C. Lai; 1. Introduction; 2. Molecular Carcinogenesis of HCV; 2.1. Induction of Mutator Phenotype; 2.2. Chromosome Translocation; 2.3. Reactive Oxygen Species (ROS); 2.4. Nitric Oxide2.5. Inhibition of DNA Damage Repair2.6. Oncogenic Activities of the HCV Core Protein; 2.6.1. TNF-α; 2.6.2. MAPK and AP-1; 2.6.3. NF-κB; 2.6.4. Oxidative stress; 2.6.5. Insulin resistance; 2.6.6. PPARα; 2.6.7. Proteasome activator PA28γ; 2.6.8. SOCS-1; 2.6.9. p53; 2.7. Oncogenic Activities of the HCV NS5A Protein; 3. Other Causative Factors in HCV-associated HCC; 3.1. Chronic Liver Inflammation; 3.2. Alcohol; 4. Endoplasmic Reticulum Stress and HCV Pathogenesis; 5. Gene Expression Profile of HCC; 6. HCV and Lymphomagenesis; 6.1. Induction of IgHypermutation by HCV6.2. Induction of DNA Translocation between IgGenes and Proto-Oncogenes by HCV Viruses are the causes of approximately 25% of human cancers. Due to their importance in carcinogenesis, there is a desperate need for a book that discusses these viruses. This book is therefore timely, providing a comprehensive review of the molecular biology of oncogenic viruses and the cancers they cause. Viruses that are discussed in the individual chapters include hepatitis B virus, hepatitis C virus, human papilloma viruses, Epstein-Barr virus, Kaposi's sarcoma virus and human T-cell leukemia virus type 1. This book provides up-to-date information for graduate students, postdoctoral feOncogenic virusesHepatitis virusesHerpesvirusesOncogenic viruses.Hepatitis viruses.Herpesviruses.616.9101616.99/4019616.994019Ou J.-H. James(Jing-hsiung James),1954-1537991Yen T. S. Benedict(Tien-Sze Benedict),1953-2009.1537992MiAaPQMiAaPQMiAaPQBOOK9910780891803321Human oncogenic viruses3787680UNINA02839oam 2200649I 450 991079203530332120230617031536.01-136-08066-X0-203-35010-31-299-28747-61-136-08058-910.4324/9780203350102 (CKB)2560000000099833(EBL)1144466(OCoLC)831119634(SSID)ssj0000904480(PQKBManifestationID)11506340(PQKBTitleCode)TC0000904480(PQKBWorkID)10921243(PQKB)11085412(MiAaPQ)EBC1144466(Au-PeEL)EBL1144466(CaPaEBR)ebr10670583(CaONFJC)MIL459997(OCoLC)830322460(FINmELB)ELB136571(EXLCZ)99256000000009983320130331d2005 uy 0engur|n|---|||||txtccrSegregated schools educational apartheid in post-civil rights America /Paul StreetNew York :Routledge,2005.1 online resource (227 p.)Positions : education, politics, and cultureDescription based upon print version of record.0-415-95116-X 0-415-95115-1 Includes bibliographical references and index.Cover; SEGREGATED SCHOOLS; Title Page; Copyright Page; Table of Contents; SERIES EDITORS' INTRODUCTION; Introduction: No Birthday Bash for Brown; 1 Still and Increasingly Separate; 2 Still Savage School Inequalities; 3 Separate But Adequate; 4 The Deeper Inequality; 5 Why Separatism Matters; NOTES; INDEXFifty years after the US Supreme Court ruled that ""separate but equal"" was ""inherently unequal,"" Paul Street argues that little progress has been made to meaningful reform America's schools. In fact, Street considers the racial make-up of today's schools as a state of de facto apartheid. With an eye to historical development of segregated education, Street examines the current state of school funding and investigates disparities in teacher quality, teacher stability, curriculum, classroom supplies, faculties, student-teacher ratios, teacher' expectations for students and students' expecPositions (RoutledgeFalmer (Firm))Segregation in educationUnited StatesEducational equalizationUnited StatesSegregation in educationEducational equalization379.2/63/0973Street Paul Louis.848775MiAaPQMiAaPQMiAaPQBOOK9910792035303321Segregated schools3845091UNINA