04774nam 2200637Ia 450 991079183330332120200520144314.01-61761-663-X(CKB)2560000000067933(EBL)3017942(SSID)ssj0000418529(PQKBManifestationID)12110292(PQKBTitleCode)TC0000418529(PQKBWorkID)10377006(PQKB)11676927(MiAaPQ)EBC3017942(Au-PeEL)EBL3017942(CaPaEBR)ebr10654913(OCoLC)923654443(EXLCZ)99256000000006793320090930d2010 uy 0engur|n|---|||||txtccrGenome instability and transgenerational effects[electronic resource] /Igor Kovalchuk and Olga Kovalchuk, editorsNew York Nova Science Publishersc20101 online resource (490 p.)Genetics--research and issues seriesDescription based upon print version of record.1-60876-831-7 Includes bibliographical references and index.""GENOME INSTABILITY AND TRANSGENERATIONAL EFFECTS""; ""GENOME INSTABILITY AND TRANSGENERATIONAL EFFECTS""; ""CONTENTS ""; ""PREFACE ""; ""GENETIC AND EPIGENETIC REGULATION OF TRANSGENERATIONAL CHANGES IN GENOME STABILITY: AN OVERVIEW""; ""REFERENCES ""; ""GENETIC AND EPIGENETIC MECHANISMS ENSURING STABILITY OF MAMMALIAN GENOMES""; ""ABSTRACT ""; ""INTRODUCTION ""; ""GENETIC MECHANISMS OF GENOME STABILITY ""; ""Direct Reversal of Damage ""; ""Base Excision Repair ""; ""Nucleotide Excision Repair ""; ""Mismatch Repair ""; ""Repair of DNA Strand Breaks by Homologous Recombination """"Non-Homologous End Joining """"Cell Cycle Checkpoints ""; ""EPIGENETIC REGULATION OF GENOMIC STABILITY ""; ""DNA Methylation ""; ""Histone Modifications ""; ""Short RNA-Mediated Silencing ""; ""CONCLUSION ""; ""REFERENCES ""; ""GENETIC AND EPIGENETIC REGULATION OF GENOME STABILITY IN PLANTS""; ""ABSTRACT ""; ""INTRODUCTION ""; ""1. ENDOGENOUS AND EXOGENOUS FACTORS THAT AFFECT GENOME STABILITY""; ""1.1. Reactive Oxygen Species Challenge DNA the Repair Machinery and Decrease Genome Stability ""; ""1.2. The Choice of DNA Repair Pathway May Regulate Plant Genome Stability """"1.3. The Importance of Plant Genome Plasticity for Stress Tolerance and Genome Evolution""""2. MECHANISMS AND FUNCTIONS OF EPIGENETIC REGULATIONS IN THE PLANT GENOME ""; ""2.1. DNA Methylation Is a Critical Component in the System of Epigenetic Modifications in Plants""; ""2.2. Histone Modifications and DNA Methylation Are Interdependent ""; ""2.3. Chromatin Remodeling Shapes Chromatin Structure and Complements DNA and Histone Modifications""; ""3. EPIGENETIC MODIFICATIONS â€? A STRESS-RESPONSIVE MECHANISM CONTROLLING GENE REGULATION AND GENOME STABILITY""""3.1. Effects of Stress on Epigenetic Regulations """"3.2. Small RNAs May Direct Epigenetic Modifications to a Specific Genomic Locus""; ""3.2.1. The Complexity and Functional Redundancy of smRNA Biogenesis Pathways in Arabidopsis ""; ""3.2.2. Mechanisms of smRNA-Directed Epigenetic Regulations ""; ""3.2.3. Small RNA Biogenesis is a Sensitive Stress-Responsive System ""; ""4. INDUCIBLE EPIGENETIC CHANGES MAY CHANGE GENOME STABILITY AND GUIDE GENOME EVOLUTION""; ""CONCLUDING REMARKS ""; ""ACKNOWLEDGMENTS ""; ""REFERENCES ""; ""EVOLUTION OF THE FPG/NEI FAMILY OF DNA GLYCOSYLASES """"ABSTRACT """"ABBREVIATIONS ""; ""INTRODUCTION ""; ""METHODS ""; ""EVENTS IN THE FPG/NEI PHYLOGENY ""; ""Horizontal Transfer ""; ""Changes in Substrate Specificity ""; ""Changes in the Structural Zinc-Finger Motif ""; ""Expansion within the Actinobacteria ""; ""THE ENZYMATIC FUNCTION OF THE FPG2 GLADE REMAINS UNKNOWN ""; ""CONCLUSION ""; ""REFERENCES ""; ""STRESS-INDUCED MUTAGENESIS IN BACTERIA ""; ""ABSTRACT ""; ""INTRODUCTION ""; ""STRESSFUL (MUTAGENIC) FACTORS ""; ""STRESS RESPONSE TO ENDOGENOUS AND EXOGENOUS DNA-DAMAGING AGENTS""; ""TRANSLESION DNA SYNTHESIS """"THE GENERAL STRESS RESPONSE ""Genetics - Research and IssuesEpigenesisMutation (Biology)Variation (Biology)Epigenesis.Mutation (Biology)Variation (Biology)572.8/77Kovalchuk Igor1520211Kovalchuk OlgaMD.1520212MiAaPQMiAaPQMiAaPQBOOK9910791833303321Genome instability and transgenerational effects3758757UNINA04129nam 2200661Ia 450 991077917240332120230802005042.00-8047-8293-810.1515/9780804782937(CKB)2550000000100949(EBL)915577(OCoLC)793996592(SSID)ssj0000736881(PQKBManifestationID)11422571(PQKBTitleCode)TC0000736881(PQKBWorkID)10782401(PQKB)10919042(MiAaPQ)EBC915577(DE-B1597)564922(DE-B1597)9780804782937(Au-PeEL)EBL915577(CaPaEBR)ebr10559575(OCoLC)1178769410(EXLCZ)99255000000010094920120221d2012 uy 0engur|n|---|||||txtccrContractors and war the transformation of US expeditionary operations /editors, Christopher Kinsey, Malcolm Hugh PattersonStanford, CA Stanford University Press20121 online resource (353 p.)Description based upon print version of record.0-8047-6990-7 0-8047-6991-5 Includes bibliographical references and index.Frontmatter --Contents --Acknowledgments --Introduction --1. Overview of American Government Expeditionary Operations Utilizing Private Contractors --2. Attitudes on the Ground: What Soldiers Think about Civilian Contractors --3. Looking Beyond Iraq: Contractors in US Global Activities --4. The Elephant in the Room --5. Sharing the Same Space: The Evolving Relationship between US NGOs, Battlefield Contractors, and US Armed Forces --6. PMSCs and Risk in Counterinsurgency Warfare --7. Contractors and the Law --8. Contractors’ Wars and the Commission on Wartime Contracting --9. Private Contractors, Public Consequences: The Need for an Effective Criminal Justice Framework --10. How to Decide When a Contractor Source Is Better to Use Than a Government Source --11. Reforming the US Approach to Stabilization and Reconstruction Operations --12. Contractors Supporting Military Operations: Many Challenges Remain --Conclusion --Contributors --IndexThe U.S. military is no longer based on a Cold War self-sufficient model. Today's armed forces are a third smaller than they were during the Cold War, and yet are expected to do as much if not more than they did during those years. As a result, a transformation is occurring in the way the U.S. government expects the military to conduct operations—with much of that transformation contingent on the use of contractors to deliver support to the armed forces during military campaigns and afterwards. Contractors and War explains the reasons behind this transformation and evaluates how the private sector will shape and be shaped by future operations. The authors are drawn from a range of policy, legislative, military, legal, and academic backgrounds. They lay out the philosophical arguments supporting the use of contractors in combat and stabilization operations and present a spectrum of arguments that support and criticize emergent private sector roles. The book provides fresh policy guidance to those who will research, direct, and carry out future deployments.Defense contractsUnited StatesContracting outUnited StatesGovernment contractorsUnited StatesPrivate military companiesUnited StatesUnited StatesArmed ForcesProcurementDefense contractsContracting outGovernment contractorsPrivate military companies355.6/2120973Kinsey Christopher1559354Patterson Malcolm Hugh1959-1559355MiAaPQMiAaPQMiAaPQBOOK9910779172403321Contractors and war3824376UNINA