06413nam 2200625Ia 450 991045169560332120200520144314.01-281-79189-X97866117918960-387-69057-310.1007/978-0-387-69057-5(CKB)1000000000492339(EBL)364191(OCoLC)288472766(SSID)ssj0000117286(PQKBManifestationID)11898363(PQKBTitleCode)TC0000117286(PQKBWorkID)10043119(PQKB)10708817(DE-He213)978-0-387-69057-5(MiAaPQ)EBC364191(PPN)129059617(Au-PeEL)EBL364191(CaPaEBR)ebr10252325(CaONFJC)MIL179189(EXLCZ)99100000000049233920080503d2008 uy 0engur|n|---|||||txtccrThe cancer degradome[electronic resource] proteases and cancer biology /edited by Dylan Edwards ... [et al.]1st ed. 2008.New York Springerc20081 online resource (946 p.)Description based upon print version of record.0-387-69056-5 Includes bibliographical references and index.The Degradome and Its Analysis -- Protease Genomics and the Cancer Degradome -- The CLIP-CHIP™: A Focused Oligonucleotide Microarray Platform for Transcriptome Analysis of the Complete Human and Murine Cancer Degradomes -- The Hu/Mu ProtIn Chip: A Custom Dual-Species Oligonucleotide Microarray for Profiling Degradome Gene Expression in Tumors and Their Microenvironment -- Quantitative Real-Time PCR Analysis of Degradome Gene Expression -- Identification of Protease Substrates by Mass Spectrometry Approaches-1 -- Identification of Protease Substrates by Mass Spectrometry Approaches-2 -- Activity-Based Imaging and Biochemical Profiling Tools for Analysis of the Cancer Degradome -- Images of Cleavage: Tumor Proteases in Action -- Insights into Protease Function -- Proteolytic Pathways: Intersecting Cascades in Cancer Development -- Physiological Functions of Plasminogen Activation: Effects of Gene Deficiencies in Humans and Mice -- The Plasminogen Activation System in Tissue Remodeling and Cancer Invasion -- The Urokinase Plasminogen Activator Receptor as a Target for Cancer Therapy -- The Endocytic Collagen Receptor, uPARAP/Endo180, in Cancer Invasion and Tissue Remodeling -- Physiological and Pathological Functions of Type II Transmembrane Serine Proteases: Lessons from Transgenic Mouse Models and Human Disease-Associated Mutations -- Roles of Cysteine Proteases in Tumor Progression: Analysis of Cysteine Cathepsin Knockout Mice in Cancer Models -- In Vitro and In Vivo Models of Angiogenesis to Dissect MMP Functions -- The Surface Transplantation Model to Study the Tumor–Host Interface -- Unravelling the Roles of Proteinases in Cell Migration In Vitro and In Vivo -- New Insights into MMP function in Adipogenesis -- TIMPs: Extracellular Modifiers in Cancer Development -- The Interface Between Proteolysis and Cell Signalling -- Invadopodia: Interface for Invasion -- uPAR and Proteases in Mobilization of Hematopoietic Stem Cells -- The Urokinase Receptor and Integrins Constitute a Cell Migration Signalosome -- Measuring uPAR Dynamics in Live Cells -- Janus-Faced Effects of Broad-Spectrum and Specific MMP Inhibition on Metastasis -- Cytokine Substrates: MMP Regulation of Inflammatory Signaling Molecules -- Matrix Metalloproteinases as Key Regulators of Tumor–Bone Interaction -- The Degradome as Source of Cancer Diagnostic and Markers -- The Plasminogen Activation System as a Source of Prognostic Markers in Cancer -- Cysteine Cathepsins and Cystatins as Cancer Biomarkers -- Novel Degradome Markers in Breast Cancer -- Meta-Analysis of Gene Expression Microarray Data: Degradome Genes in Healthy and Cancer Tissues -- Degradome Gene Polymorphisms -- TIMP-1 as a Prognostic Marker in Colorectal Cancer -- Novel Therapeutic Strategies -- Structure and Inhibition of the Urokinase-Type Plasminogen Activator Receptor -- Engineered Antagonists of uPA and PAI-1 -- MMP Inhibitor Clinical Trials – The Past, Present, and Future -- Tailoring TIMPs for Selective Metalloproteinase Inhibition -- Third-Generation MMP Inhibitors: Recent Advances in the Development of Highly Selective Inhibitors -- Protease-Activated Delivery and Imaging Systems -- Development of Tumour-Selective and Endoprotease-Activated Anticancer Therapeutics -- Targeting Degradome Genes via Engineered Viral Vectors.Proteases that act in the extracellular environment have been historically associated with tumorigenesis and metastasis by virtue of their ability to carry out "path-clearing" for cancer cells. In the past few years it has become clear that they also shape the pericellular signaling environment, with profound consequences for cell fate and phenotype in both normal development and disease states. The repertoire of proteases that cells and tissues coordinately regulate in order to modulate their local environment is the DEGRADOME – which in humans is represented by at least 569 proteases in five catalytic classes. "The Cancer Degradome: Proteases in Cancer Biology" , edited by Dylan Edwards, Francesco Blasi, Gunilla-Høyer-Hansen and Bonnie Sloane, covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; how protease activity can be imaged both in vitro and in vivo; how gene knockout mice have improved our knowledge of the roles of proteases in cancer; the links that have emerged between proteolysis and cell signaling; how the Degradome can be a useful source of diagnostic and prognostic markers; and finally new approaches to target proteolysis for therapy.CancerMolecular aspectsProteolytic enzymesElectronic books.CancerMolecular aspects.Proteolytic enzymes.616.994Edwards Dylan R1000116MiAaPQMiAaPQMiAaPQBOOK9910451695603321The cancer degradome2295694UNINA03955nam 2200877 450 991079104530332120230125221551.01-60649-811-8(CKB)2550000001273463(EBL)1664447(SSID)ssj0001215754(PQKBManifestationID)11688869(PQKBTitleCode)TC0001215754(PQKBWorkID)11178185(PQKB)10008764(OCoLC)878077910(CaBNVSL)swl00403318(Au-PeEL)EBL1664447(CaPaEBR)ebr10861552(CaONFJC)MIL595490(CaSebORM)9781606498101(MiAaPQ)EBC1664447(EXLCZ)99255000000127346320140423d2014 fy 0engur|n|---|||||txtccrEthical leadership in sport what's your ENDgame? /Pippa GrangeFirst edition.New York, New York (222 East 46th Street, New York, NY 10017) :Business Expert Press,2014.1 online resource (160 p.)Giving voice to values on business ethics and corporate social responsibility collection,2333-8814Part of: 2014 digital library.1-60649-810-X 1-306-64239-6 Includes bibliographical references (pages 131-133) and index.Introduction -- 1. State of play -- 2. "Doing" ethics -- 3. Applying the big ideas -- 4. What you might see at the top of the "slippery slope" -- 5. A case study -- 6. Making it stick -- 7. Your role as an ethical leader -- Appendix -- Notes -- References -- Index.A practical guide on how to navigate the complexities of ethical leadership in sport, recognizing the increasing pressure placed on individuals and organizations in sport to ruthlessly compete to win, and at the same time to be exemplary social role models. Most leaders know right from wrong, but giving voice to your values isn't always straightforward. This book explores how to approach the ethical decisions, dilemmas, and value-based conflicts that emerge for leaders in sports organizations in order to make good choices, drive a sound culture, and reduce the risk of going awry. The approach is twofold: Coaching for the leader on how to make and act on an ethical decision when faced with a dilemma; and an exploration of those deep personal values and beliefs about self and sport that inform how the leader thinks and acts. The book considers ethics in the context of modern sport and highlights the classic ethical traps and cultural slippery slopes to avoid using case studies and examples.2014 digital library.Giving voice to values on business ethics and corporate social responsibility collection.2333-8814SportsMoral and ethical aspectsLeadershipMoral and ethical aspectsRole modelsSports administrationethical leadershipENDgameculturesportorganizationswinningsocial responsibilityrole modelsethical decisionsdilemmasvalue-based conflictsleadership coachingvaluesbeliefsethical contentethical trapsintegritySportsMoral and ethical aspects.LeadershipMoral and ethical aspects.Role models.Sports administration.175Grange Pippa.1547907MiAaPQMiAaPQMiAaPQBOOK9910791045303321Ethical leadership in sport3804509UNINA