05714oam 22014414a 450 991079067870332120220930214723.00-691-16847-41-4008-4846-610.1515/9781400848461(CKB)2550000001125726(EBL)1329785(SSID)ssj0001001028(PQKBManifestationID)12394589(PQKBTitleCode)TC0001001028(PQKBWorkID)10966637(PQKB)11448522(MiAaPQ)EBC1329785(StDuBDS)EDZ0000142002(DE-B1597)474190(OCoLC)1004867046(DE-B1597)9781400848461(OCoLC)1273306595(MdBmJHUP)musev2_77334(PPN)199244251(EXLCZ)99255000000112572620150921e20162013 uy 0engur|nu---|u||utxtccrThe Alzheimer ConundrumEntanglements of Dementia and Aging /Margaret LockCourse BookPrinceton :Princeton University Press,2016.©2016.1 online resource (323 p.)Originally published: 2013.0-691-14978-X 1-299-95116-3 Includes bibliographical references and index.Acknowledgments -- Orientations -- Making and remaking Alzheimer disease -- Striving to standardize Alzheimer disease -- Paths to Alzheimer prevention -- Embodied risk made visible -- Alzheimer genes: biomarkers of prediction and prevention -- Genome-wide association studies: back to the future -- Living with embodied omens -- Chance untamed and the return of fate -- Transcending entrenched tensions -- Portraits from the mind -- Notes -- Bibliography -- Index.Due to rapidly aging populations, the number of people worldwide experiencing dementia is increasing, and the projections are grim. Despite billions of dollars invested in medical research, no effective treatment has been discovered for Alzheimer's disease, the most common form of dementia. The Alzheimer Conundrum exposes the predicaments embedded in current efforts to slow down or halt Alzheimer's disease through early detection of pre-symptomatic biological changes in healthy individuals. Based on a meticulous account of the history of Alzheimer's disease and extensive in-depth interviews, Margaret Lock highlights the limitations and the dissent associated with biomarker detection. Lock argues that basic research must continue, but should be complemented by a public health approach to prevention that is economically feasible, more humane, and much more effective globally than one exclusively focused on an increasingly harried search for a cure.Older peopleMental healthfast(OCoLC)fst01199117BrainAgingMolecular aspectsfast(OCoLC)fst00837576Alzheimer's diseaseAge factorsfast(OCoLC)fst01750368BrainAgingMolecular aspectsOlder peopleMental healthAlzheimer's diseaseAge factorsAPOE.Alois Alzheimer.Alzheimer disease.Alzheimer enterprise.Alzheimer genetics.Alzheimer prevention.Alzheimer world.Alzheimer's disease.DNA samples.DNA.GWAS.Huntington disease.aging population.aging populations.aging societies.amyloid cascade hypothesis.amyloid cascade process.behavioral changes.biomarkers.biosociality.breast cancer.clinical diagnosis.clinical settings.control samples.dementia.diagnosis.divination.early-onset.environmental variables.epidemiological research.epidemiology.epigenetics.ethnographic research.expert knowledge.family practice settings.gene function.genes.genetic testing.geneticization.genome-wide association studies.genomics.global economy.late-onset.localization theory.medical publications.memory clinics.memory loss.micro-medical management.mild cognitive impairment.molecular approach.molecular biologists.molecularization.neuritic amyloid plaques.neurofibrillary tangles.neuroimaging.prevention.prodromal.public health.research.throughput technology.Older peopleMental health.BrainAgingMolecular aspects.Alzheimer's diseaseAge factors.BrainAgingMolecular aspects.Older peopleMental health.Alzheimer's diseaseAge factors.362.1968/31Lock Margaret M.1009391MdBmJHUPMdBmJHUPBOOK9910790678703321The Alzheimer Conundrum3710283UNINA