03246nam 2200637 a 450 991078997930332120200520144314.01-283-86458-40-8135-5232-X10.36019/9780813552323(CKB)2670000000155076(EBL)862757(OCoLC)778339942(SSID)ssj0000614222(PQKBManifestationID)11363244(PQKBTitleCode)TC0000614222(PQKBWorkID)10588421(PQKB)11586850(MdBmJHUP)muse19688(DE-B1597)526183(OCoLC)1040058489(DE-B1597)9780813552323(Au-PeEL)EBL862757(CaPaEBR)ebr10537896(CaONFJC)MIL417708(MiAaPQ)EBC862757(EXLCZ)99267000000015507620120320d2011 uy 0engur|||||||nn|ntxtccrCrafting truth[electronic resource] documentary form and meaning /Louise Spence and Vinicius NavarroNew Brunswick, N.J. Rutgers University Press20111 online resource (294 p.)Description based upon print version of record.0-8135-4902-7 Includes bibliographical references and index.pt. 1. General concepts -- pt. 2. Structural organization -- pt. 3. Formal techniques.Documentaries such as Zana Briski and Ross Kauffman's Born into Brothels, Michael Moore's Fahrenheit 9/11, Jeffrey Blitz's Spellbound, along with March of the Penguins and An Inconvenient Truth have achieved critical as well as popular success. Although nonfiction film may have captured imaginations, many viewers enter and leave theaters with a nanve concept of "truth" and "reality"-for them, documentaries are information sources. But is truth or reality readily available, easily acquired, or undisputed? Or do documentaries convey illusions of truth and reality? What aesthetic means are used to build these illusions? A documentary's sounds and images are always the product of selection and choice, and often underscore points the filmmaker wishes to make. Crafting Truth illuminates the ways these films tell their stories; how they use the camera, editing, sound, and performance; what rhetorical devices they employ; and what the theoretical, practical, and ethical implications of these choices are. Complex documentary concepts are presented through easily accessible language, images, and a discussion of a wide range of films and videos to encourage new ways of thinking about and seeing nonfiction film.Documentary filmsHistory and criticismDocumentary filmsProduction and directionDocumentary filmsHistory and criticism.Documentary filmsProduction and direction.070.1/8070.18Spence Louise1486667Navarro Vinicius1486668MiAaPQMiAaPQMiAaPQBOOK9910789979303321Crafting truth3706240UNINA05451nam 2200613 450 991082911040332120200520144314.01-118-78852-41-118-78854-0(CKB)3710000000329622(EBL)1895601(SSID)ssj0001400900(PQKBManifestationID)12604380(PQKBTitleCode)TC0001400900(PQKBWorkID)11338791(PQKB)11697435(Au-PeEL)EBL1895601(CaPaEBR)ebr11005763(CaONFJC)MIL688522(iGPub)WILEYB0017391(PPN)189379219(MiAaPQ)EBC1895601(OCoLC)899941813(EXLCZ)99371000000032962220141015h20152015 uy| 0engur|n|---|||||txtccrBlood-brain barrier in drug discovery optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs /edited by Li Di, Edward H. Kerns1st ed.Hoboken, New Jersey :John Wiley & Sons Inc.,[2015]©20151 online resource (607 p.)Description based upon print version of record.1-118-78835-4 Includes bibliographical references and index.Machine generated contents note: Summary List of Chapters1. Overview/Introduction / Li Di (Pfizer Inc.), Edward H. Kerns (Pharmacokinetics of Brain Exposure)2. Pharmacokinetics of CNS penetration / Andreas Reichel (Bayer)3. Free Drug Hyposthesis for CNS Drug Candidates / Xingrong Liu (Genentech)4. Species Differences and impact of desease state on BBB / Jean-Marie Nicolas (UCB Pharma S.A.)Mechanisms of Drugs Across the Blood-Brain Barrier5. Passive diffusion permeability of the BBB - examples and SAR / Phil Jeffrey (GSK)6. Efflux transport at the BBB - examples and SAR / Jerome Hochman (Merck)7. Uptake transport at the BBB - examples and SAR / Zack Cheng (AstraZeneca)8. Uptake of proteins and antibodies at the BBB / William Pardridge (UCLA)Predicting and Measuring Brain Exposure of Drugs9. In silico tools for assessing brain exposure / Hongming Chen (AstraZeneca)10. In vitro assays for assessing BBB permeability - vascular cells, artificial membranes, brain slice, cell uptake / Winfried Neuhaus (University of Vienna)11. Human-based in vitro endothelial cell models / Eric Shusta (University of Wisconsin)12. In vitro assays for assessing brain binding / Li Di (Pfizer)13. In vivo studies of brain exposure / Edward H. Kerns14. PBPK models for BBB / Elizabeth de Lange (Leiden University)15. PK/PD modeling of CNS drug candidates / Johan Gabrielsson (Swedish University)16. Microdialysis to assess free drug concentration in brain / William Kielbasa (Lilly)17. Imaging technique for CNS drug discovery / Lei Zhang (Pfizer Inc.)Modulating Brain Penetration of Leads During Drug Discovery18. Designing CNS drugs for optimal brain exposure / Zoran Rankovic (Lilly)19. Case studies of CNS drug optimization - medicinal chemistry and CNS biology perspectives / Kevin J. Hodgetts (Harvard NeuroDiscovery Center)20. Designing peripheral drugs for minimal brain exposue / Peter Bungay (Pfizer)21. Case studies of non-CNS drugs to minimize brain penetration - Nonsudative antihistamines / Andrew Crowe (Curtin University)Case Studies in CNS Drug Discovery22. Case study 1 on discovery of a successful CNS drug - Fycompa (AMPA Receptor Antagonist) / Andrew Satlin and Antonio Laurenza (Eisai)23. Case study 2 on discovery of a successful CNS drug - Vortioxetine (Serotonin Modulator and Stimulator) / Benny Bang-Andersen (Lundbeck)Drug Delivery Techniques to CNS24. Brain delivery using nanotechnology / Xinguo Jiang (Fudan University)25. Intranasal delivery to CNS / Lisbeth Illum (University of Nottingham)Future Prospective in Blood Brain Barrier Advancement26. Conclusion Remarks / Joan Abbott (King's College)."Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant - and most challenging - areas of drug discovery. Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects. Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies. Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes. Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK). Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market"--Provided by publisher.BrainEffect of drugs onBlood-brain barrierBrainEffect of drugs on.Blood-brain barrier.615.7/8Di LiKerns Edward HarvelMiAaPQMiAaPQMiAaPQBOOK9910829110403321Blood-brain barrier in drug discovery3946325UNINA