04093oam 2200625I 450 991078961410332120230725031008.00-429-06420-91-62870-602-31-4398-4641-310.1201/b10729(CKB)2670000000081220(EBL)681292(OCoLC)707923709(SSID)ssj0000473952(PQKBManifestationID)11335335(PQKBTitleCode)TC0000473952(PQKBWorkID)10449514(PQKB)11079430(MiAaPQ)EBC681292(Au-PeEL)EBL681292(CaPaEBR)ebr10456272(CaONFJC)MIL692605(EXLCZ)99267000000008122020180331d2011 uy 0engur|n|---|||||txtccrTransportation systems reliability and safety /B.S. DhillonBoca Raton :CRC Press,2011.1 online resource (230 p.)Description based upon print version of record.1-322-61323-0 1-4398-4640-5 Includes bibliographical references.Front Cover; Contents; Preface; About the Author; Chapter 1: Introduction; Chapter 2: Reliability and Safety Mathematics; Chapter 3: Reliability and Safety Basics; Chapter 4: Methods for Performing Transportation System Reliability and Safety Analysis; Chapter 5: Transportation System Failures; Chapter 6: Transportation System Reliability Modeling; Chapter 7: Rail Safety; Chapter 8: Truck and Bus Safety; Chapter 9: Airline and Ship Safety; Chapter 10: Human Error in Rail and Road Transportation Systems; Chapter 11: Human Error in Aviation and Sea Transportation SystemsBibliography: Literature on the Reliability and Safety of Transportation SystemsBack CoverDuring day-to-day use, thousands of lives are lost each year due to accidents, directly or indirectly, resulting from poor transportation system reliability and safety. In the United States, automobile accidents alone result in around 42,000 deaths per year, costing billions of dollars to the economy each year. A common subject in journal articles and conference proceedings, most of the recent research on transportation systems reliability and safety is scattered in different resources. Until now.Drawing together the latest research spread throughout the literature, Transportation Systems Reliability and Safety eliminates the need to consult many different and diverse sources to obtain up-to-date information and research. It contains a chapter on mathematical concepts and another chapter on reliability and safety basics that form a foundation for understanding the contents of subsequent chapters. The book also presents a chapter devoted to methods for performing transportation system reliability and safety analysis. It includes a reference section at the end of each chapter for readers who wish to delve deeper into a specific area. The author clearly and concisely covers topics in such a manner that readers require no previous knowledge to understand the concepts. He provides examples and their solutions as well as numerous problems at the end of each chapter to test reader comprehension. The presentation of historical information paired with recent research give readers a foundation for understanding where the field is now and snapshot of where it may be going--Provided by publisher.Transportation engineeringTransportationSafety measuresTransportationReliabilityTransportation engineering.TransportationSafety measures.TransportationReliability.629.04028/9Dhillon B. S(Balbir S.),1947,12038MiAaPQMiAaPQMiAaPQBOOK9910789614103321Transportation systems reliability and safety3763111UNINA05091nam 22006014a 450 991077732890332120230422042928.01-86094-648-8(CKB)1000000000002282(EBL)1223625(SSID)ssj0000278852(PQKBManifestationID)11238042(PQKBTitleCode)TC0000278852(PQKBWorkID)10259042(PQKB)10822787(MiAaPQ)EBC1223625(WSP)0000P085(Au-PeEL)EBL1223625(CaPaEBR)ebr5000419(CaONFJC)MIL492170(OCoLC)854974145(EXLCZ)99100000000000228220000731d2000 uy 0engur|n|---|||||txtccrDrugs and the older population[electronic resource] /editors, Peter Crome, Gary FordLondon Imperial College Press ;River Edge, NJ Distributed by World Scientific Pub. Co.20001 online resource (728 p.)Description based upon print version of record.1-86094-099-4 Includes bibliographical references and index.Foreword; Introduction; List of Contributors; Contents; CHAPTER 1 Pharmacoepidemiology and the Elderly; Introduction; Types of Pharmacoepidemiologic Studies; Adverse and Beneficial Effects of Drug Therapy; Drug Utilization Studies; Antipsychotic Drugs; Thrombolysis in Acute Myocardial Infarction; Opioids for Pain Management in Cancer; Pharmacoeconomic Studies; Quality-of-life Studies; Importance of Postmarketing Drug Surveillance; Principles of Pharmacoepidemiologic Research; The Frequency of Adverse Drug Events; Study Designs; Observational Studies; Ecologic (correlational) StudiesCross-sectional StudiesCase-control Studies; Cohort Studies; Common Types of Error in Observational Studies; Experimental Studies; Measures of Association; Data Sources for Observational Pharmacoepidemiologic Studies; Future Research Directions; References; CHAPTER 2 Drug Use and Older People: Sociological Perspectives; Introduction; The Role of Biomedicine; Doctors and the Elderly; Social Characteristics and Patterns of Drug Use; Drugs and the Culture of Ageing; Empowering Older People: The Role of Self-health Care and Consumerism; ReferencesCHAPTER 3 Economic Aspects of Drugs and Older PeopleIntroduction; What is Health Economics?; Demographic Trends; Life Expectancy; Prevalence of Acute and Chronic Ill-Health; GP Consultation Rates; Prescription Items Dispensed; Prescription Costs; Health Economics; Ten Common Mistakes in Health Economics; Methods of Analysis; Costs; Where Costs Fall; The Type of Costs; Outcomes; Sensitivity Analysis; Different Perspective; References; CHAPTER 4 Pharmacokinetics; Introduction; Drugs and the Older Population; Pharmacokinetics, Pharmacodynamics and Drug EffectsFactors Influencing Pharmacokinetics in Older PeopleAge Related Changes in Drug Absorption and Bioavailability; Absorption; First Pass Metabolism and Bioavailability; Age Related Changes in Drug Distribution; Volume of Distribution; Protein Binding; Age Related Changes in Drug Clearance; Age Related Changes in Renal Excretion; Age Related Changes in Hepatic Clearance; Phase 1 Metabolism and Ageing; Factors Contributing to Age Related Reductions in Liver Metabolism; Phase 2 Metabolism and Ageing; Frailty, Disease and Drug Metabolism; Frailty; Disease; Conclusions; Research Work to DateDirections for Future ResearchReferences; CHAPTER 5 Pharmacodynamics; Introduction; Important Age-associated Pharmacodynamic Changes; Mechanisms of Pharmacodynamic Changes; Cardiovascular Drugs; Vascular Responses; Blood Pressure Lowering Drugs; Central Nervous System Drugs; Conclusions and Suggestions for Future Research; References; CHAPTER 6 Adverse Drug Reactions; Introduction; Definitions; ADRs and Hospital Admission; Studies in Hospital and Nursing Homes; Studies in Ambulatory Settings; Causes; Class of Drugs; Age; Number of Drugs; Consequences and OutcomeReports to Drug Regulatory AuthoritiesThis book is designed for all those with a scientific interest in drug treatment and the older population. The authors have all been chosen for their expertise in the field and have been drawn from both sides of the Atlantic and South Africa. The contents fall into two parts - general principles of drug use as they apply to the elderly, and specific chapters dealing with common clinical areas. The editors aim to provide a concise up to date, evidence-based, resource book.Geriatric pharmacologyGeriatric pharmacology.615.5/8/0846Crome Peter1510236Ford Gary(Gary A.)1510237MiAaPQMiAaPQMiAaPQBOOK9910777328903321Drugs and the older population3742740UNINA