03386nam 2200613 a 450 991078940570332120230725031500.01-283-14332-197866131433271-84816-367-3(CKB)2670000000095736(EBL)731333(OCoLC)738434150(SSID)ssj0000524181(PQKBManifestationID)12213183(PQKBTitleCode)TC0000524181(PQKBWorkID)10546100(PQKB)11062794(MiAaPQ)EBC731333(WSP)0000P630(Au-PeEL)EBL731333(CaPaEBR)ebr10479770(CaONFJC)MIL314332(EXLCZ)99267000000009573620110714d2011 uy 0engur|n|---|||||txtccrMicroRNAs in development and cancer[electronic resource] /editor, Frank J. SlackLondon Imperial College Press20111 online resource (300 p.)Molecular medicine and medicinal chemistry ;v. 1Description based upon print version of record.1-84816-366-5 Includes bibliographical references and index.Contents; Preface; 1 Introduction to Gene Regulation by Small RNAs Allison L. Abbott; 2 The Emerging Non-Coding RNA World Ahmad M. Khalil, Maite Huarte and John L. Rinn; 3 MicroRNAs in C. elegans Development Helge Großhans and Almuth E. Müllner; 4 MicroRNAs in Mammalian Development Andrea Ventura; 5 MicroRNAs in Hematopoietic Development Silvia Monticelli; 6 MicroRNAs Function as Tumor Suppressor Genes and Oncogenes Aurora Esquela-Kerscher; 7 Simultaneous Detection of Primary, Precursor and Mature MicroRNAs by qPCR Jinmai Jiang, Eun Joo Lee and Thomas D. Schmittgen8 Single Nucleotide Polymorphisms in MicroRNAs and MicroRNA Binding Sites with Roles in Cancer Lena J. Chin and Frank J. Slack9 MicroRNAs as Potential Diagnostics and Therapeutics Trupti Paranjape, Jae Choi and Joanne B.Weidhaas; 10 MicroRNA Target Prediction Isidore Rigoutsos and Aristotelis Tsirigos; 11 Non-Coding RNAs in Cancer - The Other Part of the Story Muller Fabbri and George A. Calin; IndexMicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represenMolecular medicine and medicinal chemistry ;v. 1.CancerGenetic aspectsSmall interfering RNACancerGenetic aspects.Small interfering RNA.572.88Slack Frank J1487345MiAaPQMiAaPQMiAaPQBOOK9910789405703321MicroRNAs in development and cancer3707141UNINA