01146nas 2200397 c 450 991014309310332120200703135651.0(CKB)111077820652308(DE-599)ZDB2031727-X(OCoLC)174594124(DE-101)021048908(EXLCZ)9911107782065230820001128a20029999 |y |gerur|||||||||||txtrdacontentcrdamediacrrdacarrierMuseumsmagazin / Stiftung Haus der Geschichte der Bundesrepublik DeutschlandonlineBonnMedienhaus Bonn2002-Frühere Jahrgänge online nicht mehr verfügbarGesehen am 03.07.20201433-349X Museumsmagazin / Haus der Geschichte der Bundesrepublik Deutschland, BonnZeitschriftgnd-content940914.3943012000*zssbb0355DE-1019001JOURNAL9910143093103321Museumsmagazin2002298UNINA04109nam 2200601 450 991078923250332120230803202224.00-309-29249-20-309-29247-6(CKB)3710000000103374(EBL)3379237(SSID)ssj0001191230(PQKBManifestationID)11708378(PQKBTitleCode)TC0001191230(PQKBWorkID)11219918(PQKB)11381147(MiAaPQ)EBC3379237(WaSeSS)bw9780309292467(Au-PeEL)EBL3379237(CaPaEBR)ebr10863892(OCoLC)923289754(EXLCZ)99371000000010337420140506h20142014 uy 0engurcnu||||||||txtccrImproving and accelerating therapeutic development for nervous system disorders workshop summary /Sheena M. Posey Norris [and three others], rapporteurs ; Forum on Neuroscience and Nervous System Disorders : Board on Health Sciences PolicyWashington, District of Columbia :National Academies Press,2014.©20141 online resource (119 p.)Description based upon print version of record.0-309-29246-8 Includes bibliographical references.""Front Matter""; ""Reviewers""; ""Contents""; ""1 Introduction and Overview""; ""2 Drug Development Challenges""; ""3 Target Identification""; ""4 Target Validation""; ""5 Opportunities to Improve and Accelerate the Drug Development Pipeline""; ""6 Perspectives on Next Steps""; ""Appendix A: References""; ""Appendix B: Workshop Agenda""; ""Appendix C: Registered Attendees"""Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials."--Publisher's website.Drug developmentCongressesDrug approvalCongressesClinical trialsCongressesDrug developmentDrug approvalClinical trials615.1Norris Sheena M. PoseyInstitute of Medicine (U.S.)MiAaPQMiAaPQMiAaPQBOOK9910789232503321Improving and accelerating therapeutic development for nervous system disorders3742586UNINA