03391oam 2200625Ma 450 991078783990332120230803195641.00-429-16877-21-4665-9487-X(CKB)2670000000560296(EBL)1604291(SSID)ssj0001358903(PQKBManifestationID)12504841(PQKBTitleCode)TC0001358903(PQKBWorkID)11299542(PQKB)11404206(MiAaPQ)EBC1604291(OCoLC)903000300(OCoLC-P)903000300(FlBoTFG)9780429168772(EXLCZ)99267000000056029620150209d2014 uy 0engur|n|||||||||txtccrHuman LongevityCRC Press20141 online resource (248 p.)Description based upon print version of record.1-322-63399-1 1-4665-9486-1 Includes bibliographical references at the end of each chapters.Chapter 5: Remarkable Longevity of Queens of Social Insects Likely Involves Dietary Manipulation to Minimize Levels of Polyunsaturates and Decrease Membrane PeroxidationChapter 6: Membrane Peroxidation Hypothesis Helps Explain Longevity in Birds, Rodents, and Whales; Chapter 7: Did Longevity Help Humans Become Super Humans?; Chapter 8: Mitochondrial Diseases and Aging Have Much in Common; Chapter 9: Revised Mitochondrial Hypothesis of Aging Highlights Energy Deficiency Caused by Errors of Replication (Mutations) of mtDNA; Chapter 10: Benefits of Polyunsaturated Mitochondrial MembranesChapter 16: Uncoupling Proteins (UCPs) of Mitochondria Purposely Waste Energy to Prevent Membrane DamageChapter 17: Mitochondrial Fission Protects against Oxidative Stress by Minting a Continuous Supply of Cardiolipin and Other Polyunsaturated Phospholipids; Chapter 18: Mitophagy Eliminates Toxic Mitochondria; Chapter 19: Longevity Genes Likely Protect Membranes; Chapter 20: Aging as a Cardiolipin Disease That Can Be Treated; Back CoverMore than 7 billion people inhabit the earth and all of them are subject to aging. This book is aimed at persons interested in a molecular explanation of how our cells age. Human Longevity: Omega-3 Fatty Acids, Bioenergetics, Molecular Biology, and Evolution is built on the proposition that we age as our mitochondria age. It suggests a revised version of Harman's famous hypothesis featuring mitochondrial oxidative and energy stresses as the root causes of aging. Human cells are protected from the ravages of aging by a battery of defensive systems including some novel mechanisms against membranAgingGenetic aspectsMitochondriaOxidative stressOmega-3 fatty acidsHealth aspectsAgingGenetic aspects.Mitochondria.Oxidative stress.Omega-3 fatty acidsHealth aspects.612.6/7MED008000SCI049000TEC012000bisacshValentine Raymond C107115Valentine David L1549128OCoLC-POCoLC-PBOOK9910787839903321Human Longevity3806794UNINA